Chuanxiong, a cultivated plant, is mainly produced in guanxian, Sichuan Province, and grows in Yunnan, Guizhou, Guangxi and other places with mild climate. Let me introduce the efficacy and function of Ligusticum chuanxiong for you, hoping to help you.

Efficacy and function of Ligusticum chuanxiong hort.

1, promoting blood circulation and qi circulation: ① used for angina pectoris of coronary heart disease, chest tightness and tenderness in precordial area. It can be used in combination with Carthami Flos, Salvia Miltiorrhiza Radix, Lignum Dalbergiae Odoriferae, Radix Paeoniae Rubra and Guanxin No.2 prescription. ② It can be used for diseases caused by qi stagnation and blood stasis, such as premenstrual period and polychromatic redness, which belongs to blood heat and can be used equally with Radix Rehmanniae, Cortex Moutan and Radix Angelicae Sinensis; Late menstruation, 1 ~ 2 months, 1 time, low back pain, abdominal pain, leucorrhea, multicolored leucorrhea during menstruation. Equivalent to angelica, processed ginger, Eucommia ulmoides and cinnamon. ③ Used for dysmenorrhea. If the abdominal pain in the front waist is severe and menstruation occurs 1 day after the pain, it is used together with Danggui, Ren Tao and Honghua. If amenorrhea is ineffective and there is no discomfort, it can be used with Angelica sinensis, Ren Tao, Zingiberis Rhizoma and Cinnamomi. For postpartum abdominal pain, it is equivalent to Angelica sinensis and Paojiang. ④ For traumatic injury and local swelling and pain, it can be used together with Gardenia, Peach kernel and safflower.

2. Expelling wind and relieving pain: ① For wind-cold headache, it belongs to wind-cold, and can be used together with Schizonepeta, Saposhnikovia divaricata and Angelica dahurica; For wind-heat, it can be used with chrysanthemum and mint. ② Rheumatic joint pain can be used equally with Notopterygium, Radix Angelicae Pubescentis and Radix Saposhnikoviae.

3. Activating qi to relieve depression: ① It can be used for swelling and pain in the upper abdomen and ribs of cholecystitis, and can be used equally with Bupleurum and Scutellaria. ② Gastritis with epigastric pain, acid regurgitation and heartburn can be combined with Taraxacum and Radix Aucklandiae.

Pharmacological effects of Ligusticum chuanxiong hort.

1, the influence on the central nervous system

Chuanxiong has obvious sedative effect. The volatile oil of Ligusticum Chuanxiong can inhibit the activity of animal brain, but it can stimulate the respiratory center, vascular motor center and spinal reflex center of medulla oblongata. Chuanxiong decoction can inhibit the spontaneous activity of rats and mice, prolong the sleep time of mice induced by pentobarbital sodium, and resist the excitatory effect of caffeine 20mg/kg. But it can't resist the convulsion caused by pentylenetetrazol in rats. 25-50g/kg Chuanxiong decoction can inhibit spontaneous activity of rats, and its sedative effect on mice is more obvious than that of rats. It can also prolong the sleep time of pentobarbital, but it can't antagonize the excitement of caffeine, nor can it prevent the convulsion or death of pentylenetetrazol and cocaine. The volatile oil of Ligusticum chuanxiong produced in Japan has inhibitory effect on the activity of animal brain, but it has excitatory effect on the vasomotor center, respiratory center and spinal cord reflex of medulla oblongata. With the increase of dose, they all become inhibitory.

2, the role of the cardiovascular system

Effects of Ligusticum chuanxiong 2. 1 on isolated hearts of toads and frogs. When the concentration is 1O-5- 10-4, the contraction amplitude increases and the heart rate is slightly slower. According to engelmann test, Chuanxiong 20 or 30g/kgig also increased the amplitude of frog heart and slowed down the heart rate. 40g/kgig, frog heart can stop. Tetramethylpyrazine iv also has cardiotonic effect on anesthetized dogs, accompanied by increased heart rate. The denervated heart still has obvious reaction to ligustrazine. High dose ligustrazine injected into vertebral artery has no obvious cardiovascular effect. Pretreatment with propranolol or reserpine can completely eliminate the effect of ligustrazine on the heart, so the effect of ligustrazine on the heart may be caused by indirectly exciting cardiac B receptor through sympathetic nerve. Ligustrazine 1, 2,4 mg/kg. Intravenous injection for min for 65438±00min in anesthetized dogs resulted in increased heart rate, enhanced myocardial contractility and vasodilation. With the increase of dose, these effects lasted for 10 minutes, the heart rate increased, the myocardial contractility increased, and the blood vessels dilated. These effects increase with the increase of dose. After 1mg/kg infusion, the minute heart rate, LVP and dp/dtmax increased, and the 2mg/kg minute heart rate, LVP, dp/dtmax and coronary blood flow increased significantly. When the dose is increased to 4 mg/kg. Min, in addition to the above indexes, LVEDP and CI, myocardial oxygen consumption and cerebral blood flow increased, while coronary artery and cerebrovascular resistance and peripheral total resistance decreased. Ligustrazine infusion 4mg/kg. Min and 1 iv20mg/kg can also cause the heart rate to increase. Propranolol ivl-2mg/kg can antagonize these effects of ligustrazine on anesthetized and awake dogs, but reserpine can not completely antagonize the effects of ligustrazine. It is reported that ligustrazine inhibits myocardial contraction and increases coronary artery flow in a dose-dependent manner in isolated guinea pig perfused heart. Iv Ligustrazine 10mg/kg significantly increased myocardial oxygen consumption, oxygen uptake rate and CBF within 1-5 minutes. After intravenous injection of ligustrazine at 5mg/kg, CBF increased 14 15 ml/min, and myocardial oxygen consumption increased1.0 0.7 ml/min after 5 minutes, which was significant. In anesthetized open-chest dogs, ligustrazine iv 10mg/kg can reduce blood pressure, external resistance and left ventricular work, and increase LVSP, LVdp/dtmax, heart rate and myocardial oxygen consumption. Ligustrazine iv has protective effect on ischemic myocardial reperfusion injury in rabbits, which may be related to promoting blood circulation to remove blood stasis, increasing coronary flow, reducing myocardial oxygen consumption and improving myocardial metabolism. Chuanxiong 1.50 mg/kg was given to rabbits ig. 1.5 unit /kg after 5 minutes, the intravenous injection of Pit 1.5 unit/kg is pit30s, and the injection is finished. Acute myocardial ischemia usually occurs after ivPit, and ECG shows that the peak value of T wave is obviously increased. The increase of T wave in the medication group was significantly lower than that in the control group, which had a very obvious effect on acute myocardial ischemia and hypoxia caused by Pit.

3. Effect on smooth muscle

10% Ligusticum chuanxiong aqueous solution. The extract can * * * a small amount of pregnant rabbit uterus, which will increase its tension and contraction, and eventually become contracture. A large amount will paralyze the uterus and stop the contraction. After continuous injection of Ligusticum chuanxiong extract into pregnant rats and pregnant rabbits, the fetus died in the uterus, but did not fall off. Therefore, it is concluded that fetal necrosis may be caused by uterine contracture of animals caused by Chuanxiong, which affects fetal nutrition. A small amount of Ligusticum Chuanxiong extract can inhibit the isolated small intestine of rabbits or guinea pigs, while a large amount can completely stop the contraction of small intestine. Ferulic acid and neutral components contained in Chuanxiong? -Lactone has spasmolytic effect on smooth muscle. Ligusticum wallichii alkaloids, ferulic acid and Ligusticum wallichii lactone all have spasmolytic effects, and Ligustilide is the main component. Ip0. 14ml/kg/kg ligustilide can alleviate the asthma reaction between histamine and acetylcholine, and its effect is similar to that of aminophylline at about 50mg/kg. Iv ligustilide can also obviously alleviate the spasm and contraction of tracheal smooth muscle caused by acetylcholine, histamine and barium chloride. Ligustrazine can also inhibit pulmonary vasoconstriction caused by hypoxia, and also inhibit vasoconstriction caused by adrenaline or barium chloride. The mechanism of ligustrazine on isolated tissues and cells shows that the relaxation effect of ligustrazine on aortic smooth muscle is very similar to that of verapamil, suggesting that ligustrazine may be a new calcium antagonist. Ligusticum chuanxiong 300mg/kg has obvious analgesic effect on mice, which is significantly different from that of the control group (P

4. In vitro antibacterial effect test.

Chuanxiong has inhibitory effects on large intestine, Sonne's dysentery, metamorphosis, suppurative infection, typhoid fever, Bacillus paratyphi and Vibrio cholerae. Ligusticum chuanxiong Hort. 1:3 also has inhibitory effect on some pathogenic fungi in vitro.

5. Anti-radiation effect

Chuanxiong decoction has a certain effect on experimental treatment of radiation sickness in animals. The water-soluble crude preparation of Ligusticum Chuanxiong has protective effects on radiation exposure and nitrogen mustard injury in rats, mice and dogs. The anti-radiation effect of Chuanxiong on rats is better than that of mice, ip is better than im, and im is better than ig.

Brief introduction of Chuanxiong

In the early years of the Tang Dynasty, Sun Simiao, the king of medicine, traveled around Qingcheng Mountain in Sichuan with his disciples, and collected medicinal materials through thorns and thorns. One day, the master and the apprentice were tired and stopped in the miscellaneous pine forest. Suddenly, they saw a big female crane playing with some small cranes by the cave in the forest. The drug king was fascinated by it and suddenly heard several small cranes screaming. I saw the big female crane drooping her head and neck, her feet trembling, and she kept purring. The medicine king immediately understood that the mother crane had an emergency.

The next morning, at first light, Master Yao and his disciples went to Qingsonglin again. Not far from the crane nest, you can clearly distinguish the * * * sound of sick cranes in the nest. Another day passed, Master Yao and his disciples went to the pine forest again, but the voice of the sick crane was no longer heard in the white crane's nest. Looking up, several white cranes were soaring in the air, and a small white flower and several leaves fell from their mouths, which looked like carrot leaves. The medicine king asked his disciples to pick it up and store it.

A few days later, the female crane has fully recovered and led the little cranes to play as usual. The medicine king observed that the crane likes to go to the ancient cave without a cliff, where there is a piece of green, and the flowers and leaves are the same as those that fell from the crane's mouth in the past. The medicine king instinctively believes that the recovery of the female crane is related to this medicine. After the experiment, he found that this plant has the functions of promoting blood circulation, dredging collaterals, expelling wind and relieving pain, so he asked his disciples to take this medicine down the mountain to treat symptomatic patients, and it really worked. Who casually chanting excitedly, "Qingcheng Mountain is a secluded place on earth, the first hole in western Sichuan. Where the crane crosses, good medicine falls from heaven. This medicine is called Chuanxiong! " "Chuanxiong" got its name from this.