It is divided into acute and chronic.

Acute: elevated body temperature, listlessness, fatigue, loss of appetite, rapid weight loss, rapid heartbeat and breathing, anemia, mild jaundice and hemoglobinuria.

Chronic: no change in body temperature, only poor appetite and emaciation.

Tetracycline 10 mg/kg body weight, 50 ~ 100 ml sugar-containing saline, slow intravenous injection, has good curative effect. Varanamine (0.0 15 ~ 0.03g for human, which is slow when injected intravenously, and will be necrotic when leaked from blood vessels) or oxytetracycline, 0/5 ~ 20mg per kg body weight, taken orally three times a day for three weeks. You can also use thiamine, 0.25 mg per kilogram of body weight, once intravenously, and repeat it two days later 1 time (this drug is toxic and not approved for use abroad).