First of all, the pharmacological action of metformin is to reduce liver sugar output and increase glycogen synthesis, but the weight loss effect is not so obvious, so it can not be regarded as a weight loss drug.
Secondly, although the incidence of adverse reactions of metformin is very low, the most serious adverse reaction of metformin is lactic acidosis. Mild lactic acidosis can cause fatigue, nausea, loss of appetite and other symptoms. In severe cases, there will be disturbance of consciousness, weakened limb reflexes and life-threatening shock. The most severe patients may need dialysis to save their lives.