This product is a benzimidazole compound, which is transferred to gastric mucosa after oral absorption and transformed into active structure under acidic conditions. This active substance binds to SH group ((H++K+)-ATPase) of proton pump, thus inhibiting the activity of this enzyme, so it can inhibit the secretion of gastric acid. 1.(h++k+)-ATPase activity inhibition Lansoprazole can inhibit the activity of (h++k+)-ATPase in dog gastric mucosa (in vitro experiment). 2. Inhibition of acid production by parietal cells Lansoprazole can inhibit the acid secretion of isolated parietal cells of dog gastric mucosa stimulated by histamine, acetylcholine and gastrin (in vitro experiment). 3. Inhibition of gastric acid secretion 1) Gastric acid secretion caused by gastrin stimulation: Oral lansoprazole 30mg 1 day for 7 consecutive days can obviously inhibit gastric acid secretion caused by gastrin, and this effect can last for 24 hours. 2) Acid secretion caused by insulin stimulation: Oral lansoprazole 30mg 1 day for 7 days in a row can obviously inhibit acid secretion caused by insulin. 3) Nocturnal gastric acid secretion: For healthy adults, oral lansoprazole 30mg 65 for 7 days and 438+0 days can obviously inhibit nocturnal gastric acid secretion. 4) 24-hour gastric acid secretion: In the 24-hour gastric juice sampling test of healthy adults, oral lansoprazole 30mg for 7 days obviously inhibited 24-hour gastric acid secretion. 5)24-hour intragastric pH monitoring: For healthy adults and patients with duodenal ulcer, oral lansoprazole 30mg for 7 consecutive days significantly inhibited gastric acid secretion for 24 hours. 6) 24-hour monitoring of pH value of lower esophagus: For patients with reflux esophagitis, oral lansoprazole 30mg for 7-9 days and 65,438 0 days significantly inhibited gastroesophageal reflux. 7) Gastric acid secretion in rats and gastric pouch dogs: This medicine can obviously and continuously inhibit the basic acid secretion in rats and the acid secretion caused by histamine, gastrin, carbamylcholine, 2- deoxy -D- glucose or immersion stress test (in duodenum). The drug also has obvious and sustained inhibitory effect on gastric acid secretion caused by various stimuli in gastric pouch dogs, and it can show stable inhibitory effect on gastric acid secretion (oral) during repeated administration. 4. The experiment of promoting the healing of chronic ulcer in rats shows that lansoprazole can obviously promote the healing of chronic gastric and duodenal ulcer caused by acetic acid. 5. The inhibition of ulcer formation has obvious inhibitory effect on water immersion stress test, gastric ulcer caused by aspirin or ethanol, duodenal ulcer caused by methylperisol or cysteamine, and reflux esophagitis (oral or duodenal administration).