Orlistat is a "weight-loss drug without side effects".
Truth:
As a "diet pill" with advertisements flying all over the sky, orlistat claims to have "no side effects". Is that really the case?
Orris, what is he?
Orlistat is an over-the-counter drug, which only acts on the intestine and hardly enters the blood. It can inhibit intestinal lipase, make it difficult to decompose macromolecular fat in food, thus reducing the absorption of fat in the body and finally achieving the effect of losing weight.
From this point of view, orlistat can really be called a traditional "slimming drug" that makes people lose weight. According to statistics, it can inhibit the fat absorption of about 1/3, and has a certain effect on reducing body weight and blood lipid. In addition, orlistat has a positive effect on insulin resistance symptoms and blood pressure level. As a non-central weight-loss drug, it only acts on the intestine and has little effect on the whole body, which is really the gospel of obese people.
Side effects of orlistat
At first glance, Ollis is really attractive. But looking at a drug can't just look at the efficacy, but also look at the side effects. Orlistat is not a "weight loss drug without side effects" spread through the Internet. On the contrary, there are many side effects.
Because orlistat inhibits the absorption of fat in food, most of the fat remains in chyme and is excreted with the intestine. Therefore, it is easy to cause symptoms such as increased stool frequency, soft stool, thin stool, greasy stool, abdominal pain and nausea.
At the same time, the influence of orlistat on intestine, endocrine and metabolism should not be underestimated. Although orlistat does not enter the blood, some of it will still be absorbed. These components have certain effects on the liver and kidney. Liver injury is an important ADR of this drug (ADR for short). People with liver and kidney function problems should pay attention to it and follow the doctor's advice. In addition, patients who are allergic to any other ingredients in orlistat should not take it. If you take other drugs at the same time, you should also avoid the adverse reactions caused by drug interaction.
For some people, orlistat is not suitable. For example,/kloc-teenagers under 0/8 years old, pregnant women and people with chronic malabsorption syndrome or cholestasis should be banned.
Orlistat is carcinogenic, so try to buy and take it under the guidance of a doctor!
Can orlistat really lose weight quickly in "one week 10 kg"?
For people with high carbohydrate intake, orlistat can't stop the absorption of carbohydrates, so a lot of carbohydrates will continue to accumulate in the body and gradually turn into fat, and the symptoms of obesity can't be effectively alleviated.
For people with high fat intake, because orlistat inhibits fat absorption, taking medicine at first will make them "not full". The body always feeds back the signal of insufficient energy, so patients will eat more than before. Generally speaking, the short-term results are not up to expectations. However, after long-term diet control and drug treatment, orlistat can not only lose weight, but also effectively reduce the visceral fat content, indirectly improve metabolic disorders and reduce the risk of obesity. At the same time, research shows that the contents of cholesterol and low-density lipoprotein in blood are also significantly reduced, effectively alleviating the problems caused by hyperlipidemia. Strictly speaking, orlistat is not a "slimming drug" that can lose weight after eating, but only reduces fat absorption.
On the other hand, because most vitamins are fat-soluble, inhibiting fat absorption will also affect the absorption of these vitamins. For people who eat less vegetables and fruits, simply using orlistat will lead to vitamin deficiency and malnutrition.
summary
The efficacy of orlistat can only be said to be an auxiliary means to lose weight, not a decisive role. The online statement that "I lost weight in 7 days 10 kg" is somewhat exaggerated.
In addition, the specific use of orlistat should be judged according to the existing obesity situation. The drug is suitable for obese or overweight people, and some product instructions recommend it for patients with body mass index greater than 24. Non-overweight people should not take this medicine, but should adopt healthy weight loss methods such as exercise and diet control.
Even if you take orlistat, you need to ensure a balanced diet of three meals a day. Only by controlling your mouth, rejecting the delicious temptations such as cakes and milk tea, and eating low-calorie food can you really lose weight. In addition, we should pay attention to the combination of diet control and exercise.
References:
Yan Mei, Li. Adverse reactions and safe application of orlistat [J]. adverse drug reactions journal, 2007(03):36-39.
Lilingou, Liu Dongfang. Clinical application of orlistat and research progress of weight loss mechanism [J]. Scientific Consultation, 2018000 (006): 51-52.
Huang Shijie. Because of the risk of cancer, the American Consumers Association asked orlistat to withdraw from the market [J]. Foreign Medicine: Pharmaceutical Volume, 2006.
Notifying country: Revision of Instructions for Orlistat Preparation by US Food and Drug Administration [20 10]359.
Chen, Wang Yige, et al. Effect of orlistat on obesity with nonalcoholic fatty liver disease and its risk factors [J]. Journal of Clinical Hepatobiliary Diseases, 2006,22 (2):123-124.
3 Zhang Zhiping, et al. Observation on the therapeutic effect of orlistat on obese patients with type 2 diabetes [J]. China Journal of Cardiovascular Diseases, 2002. Diabetes Care,1998,21(8):1288-66.
Effect of orlistat on weight and body composition of obese adolescents. Randomized controlled trial
Effects of new combination of orlistat and acarbose on tolerance, appetite and glucose metabolism in obese patients. /doi/full/ 10. 1002/OSP 4.405
Rumor Team Producer: Li Haipeng
Evaluation expert: Liu Guiyang, chief pharmacist of the Fourth Medical Center of PLA General Hospital.