The working principle of nano-crystallites is to transport drugs through the barrier layer (stratum corneum) on the surface of human skin at a stable and rapid frequency by using a very fine needle, and to open hundreds of transport channels on the epidermis with an area of several square millimeters to improve the transdermal permeability of drugs. This can not only make the drug absorb quickly and take effect, but also make the drug release evenly and slowly. Nanoneedles are nanochips.

Traditional microneedles are relatively long, easy to be infected, bleeding and painful, and the supporting products are generally single. Nanocrystalline microneedles are completely different from traditional microneedles, and the contact head is covered with nano-sized microneedles which are much thinner than hair. As long as a small chip covered with microneedles is attached to the skin, the microneedles can penetrate the stratum corneum of the epidermis and play the role of a drug barrier. When a patch filled with drugs is attached, the drugs will slowly penetrate into the epidermis and be administered continuously in a fixed amount. Achieves the effects of painless and non-invasive administration and penetration.