Rumors:
Orlistat is called oil-expelling pill on the Internet. Many people say it's the only safe diet pill. Eat if you want, and don't go on a diet or rebound. Is it true?/You don't say. /You don't say.
Rumors:
Orlistat is a lipase inhibitor acting on the gastrointestinal tract, which mainly inhibits gastric lipase and pancreatic lipase in the small intestine cavity, thus inhibiting the decomposition of ingested fat, so that undigested triglycerides are directly excreted without being absorbed by the body, thus achieving the effect of weight control.
safe
① Orlistat has 60mg and 120mg/ tablet. In the United States and South Korea, only 60mg of over-the-counter drugs are approved for sale, that is, a doctor's prescription is not required, while 120mg requires a doctor's prescription. Orlistat made in China is mainly Class A OTC and needs to be used under the guidance of pharmacists.
② In May, 2065438+00, FDA issued a message warning that orlistat may cause rare but serious risk of liver injury. In September of the same year, the US Food and Drug Administration in China requested to revise the instructions, but the original instructions of orlistat were occasionally reported as an allergic reaction to orlistat. The main clinical manifestations are itching, rash, urticaria, angioneurotic edema, bronchospasm and allergic reaction. There are few cases of herpes zoster, elevated liver transaminase and alkaline phosphatase, and few cases of severe hepatitis and pancreatitis. The causal relationship between hepatitis, pancreatitis and orlistat has not been determined. There are few reports of elevated transaminase, elevated alkaline phosphatase and severe hepatitis, and some patients need liver transplantation or may directly lead to death. There are also reports of rare allergic reactions to orlistat. The main clinical manifestations are itching, rash, urticaria, angioneurotic edema, bronchospasm and allergic reaction, and herpes zoster is very rare. Post-marketing monitoring also found reports of pancreatitis.
③2065 438+04 Risk warning of British Drug Administration: Orlistat may cause hyperoxaluria and oxalate nephropathy.
To sum up, orlistat is not an absolutely safe drug.
efficiency
① Orlistat can inhibit the absorption of triglycerides, but it can't decompose the fat synthesized in the body, and can only prevent the absorption of 30% fat. It's no use not eating fat in your diet. Moreover, orlistat can not block the energy conversion of carbohydrates, protein and other substances, so it is unscientific to lose weight only by orlistat.
The core principle of losing weight should be to adjust lifestyle, including adjusting diet, increasing physical exercise and related behavioral therapy. Medication is not the most important way to lose weight.
Uniqueness
At present, besides orlistat, there are some prescription drugs that can lose weight, such as metformin and liraglutide. Liraglutide is the main glucagon-like peptide 1 receptor agonist on the market at present, which has hypoglycemic effect. It can play a centralized role through the neuronal pathway of hypothalamus and promote satiety. However, it is not recommended to use hypoglycemic agents for weight loss.
other
① Long-term use of orlistat will affect the absorption of fat-soluble vitamins, such as vitamins A, D, E and K, etc.
② Orlistat can also affect the action of other drugs. If you take amiodarone, levothyroxine and other drugs at the same time, you need to consult your doctor Yamatonokusushi. In 20 14, the British drug regulatory agency warned that orlistat may reduce the absorption of AIDS drugs such as efavirenz and lopinavir.
(3) There is another problem. Taking orlistat, chrysanthemum may leak some oil from time to time. Although oil can be seen, it is the oil in food. Don't believe that orlistat can decompose body fat.
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