In fact, whether clothes are comfortable or not is not just from the feel. When you say comfortable, you probably mean soft. Coral velvet is soft, but airtight. It is uncomfortable to wear coral velvet pajamas after sweating.
Some are cotton, just because the cotton thread is thin and tightly woven, which is similar to thick wool scarves that are softer and thin wool scarves that are flatter.
Sticking fiber will make clothes strong, as the name implies, which is the function of sticking materials together. Wool coats are mostly wool+polyester+viscose fiber.