What is the clinical significance of the increase or decrease of serum creatinine and urine creatinine?
Increased urinary creatinine excretion is seen in hypothyroidism, some wasting diseases, liver disease, diabetes, acromegaly, gigantism, fever and hunger. ② Decreased urinary creatinine excretion can be seen in consumptive diseases, such as renal insufficiency, hyperthyroidism, anemia, paralysis, typhoid fever, tetanus, tuberculosis, muscular atrophy and muscular dystrophy.