Anything as good as Jimmy Lin's Single Men and Women (romance and comedy (both)) must be a movie.
Anne Hathaway's Love and the Elixir of Life tells the story of Maggie modoc played by Anne Hathaway, a character suffering from Parkinson's disease. She wanted to be "chic" all her life before she became seriously ill, but she met Jake Gyllenhaal, a drug dealer selling Viagra. There are many jokes between them, and the plot has changed from bitter drama to romantic comedy.