Some patients need to take aspirin for a long time.
But how to use drugs correctly?
In order to play its best effect?
What are the precautions during medication?
Professional pharmacists tell you
0 1
Aspirin can be taken in the morning and evening.
Many patients have doubts about whether aspirin should be taken in the evening or in the morning.
Liu Shaozhi, the pharmacist in charge of the Pharmacy Department of the Third Hospital of Guangzhou Medical University, said that there is controversy about the time of taking medicine in the morning and evening. Some studies believe that platelet activity is enhanced in the morning, and the high incidence of cardiovascular events is 6:00- 12:00. It is recommended to take it in the morning. Another study believes that taking aspirin at night can help lower blood pressure, so it is recommended to take it at night.
But in fact, from the mechanism of action of aspirin, the plasma concentration of aspirin can reach its peak in a few hours after taking it, but if it is taken repeatedly, its antiplatelet effect can last for several days, so whether it is taken at night or in the morning, its antiplatelet effect is persistent. Therefore, it is not necessary to take this medicine in the morning and evening, but it is more important to take it regularly for a long time.
02
Different dosage forms have specific medication time.
However, different dosage forms will affect whether to take it before or after meals.
Huang, deputy chief physician of the Department of Cardiology, Guangzhou Third Hospital, suggested that if ordinary tablets are taken, the drug in this dosage form will be decomposed in the stomach and should be taken after meals to reduce the damage to the gastric mucosa.
If you take enteric-coated tablets, the drug in this dosage form is insoluble in acidic gastric juice and soluble in alkaline intestinal juice. If you choose to take it after meals, food will delay the absorption of drugs. If it is mixed with alkaline substances in food, it may lead to the early release of enteric-coated tablets and aggravate the damage to gastric mucosa. Therefore, enteric-coated tablets should generally be taken 30 minutes-1 hour before meals.
03
It is recommended to take medicine regularly every day.
Avoid losing clothes
Many patients occasionally forget to take medicine every day. Will it matter if they miss taking medicine?
Liu Shaozhi introduced that a single dose of aspirin can effectively inhibit the activity of existing platelets in the body, but the human body will produce 10- 15% of new platelets every day, so it is necessary to take aspirin regularly every day to inhibit the production of new platelets.
Occasionally missing a dose will not have much influence on the antithrombotic effect, but if it is missed frequently, it will inevitably lead to an increase in the risk of thrombosis. Therefore, it is recommended to take medicine at a fixed time every day. If you miss the medicine of the day and think it is close to the next time, you don't need to take it on the same day, just take it at the normal dose next time, and you don't need to double the dose to avoid increasing adverse reactions; If there is a long time before the next medication, you should take it again on the same day and continue to take it at the regular dose next time.
04
Don't drink alcohol while taking the medicine.
Liu Shaozhi said that you can't drink alcohol while taking aspirin. "At the same time, drinking alcohol will increase the risk of damage to gastric mucosa and liver, and because aspirin will inhibit the activity of alcohol dehydrogenase, slow down alcohol metabolism, and make the body accumulate alcohol, it is more prone to alcoholism."
If it is inevitable to drink alcohol, it is necessary to stagger the medication time with aspirin to minimize the harm caused by the interaction between them.
05
These people are easy to take drugs.
Adverse reaction of digestive tract
When taking medicine, adverse reactions often affect the continuity of taking medicine, especially when there are symptoms such as gastrointestinal bleeding, which will make people feel afraid and resist taking medicine. Therefore, it is necessary to pay attention to the adverse reactions of aspirin in the digestive tract.
According to Huang, the following groups belong to high-risk groups: people with previous digestive tract diseases, elderly people over 65 years old, people taking high-dose aspirin, people taking anticoagulant or antithrombotic drugs at the same time, and smokers and drinkers.
For the above situation, we should consult a professional doctor and add gastric protection preparations appropriately to reduce the occurrence of adverse reactions in the digestive tract.
06
Aspirin resistance
Re-evaluate the adjustment of drug treatment
When taking aspirin cannot prevent thrombosis, it is called "aspirin resistance" in medicine. What should I do in this situation?
Liu Shaozhi introduced that, first of all, it needs to be reassessed. Is it because other risk factors besides drugs, such as blood pressure, blood sugar and blood lipid, have not been effectively controlled, do you want to quit smoking? Secondly, do you need to confirm whether you take the medicine regularly? Have you ever taken other drugs that affect the efficacy of aspirin, such as non-steroidal anti-inflammatory drugs? If all the above factors can be ruled out, when aspirin resistance occurs, measures can be taken to increase aspirin dosage or switch to other antiplatelet drugs.