Current location - Health Preservation Learning Network - Healthy weight loss - Why is nongonococcal urethritis incurable for a long time?
Why is nongonococcal urethritis incurable for a long time?
It can be treated and fully conditioned.

It is a derivative of the Nobel Prize in Medical Physiology and a revolutionary sacred product for women's maintenance in the 2 1 century. Her birth triggered a global female storm.

1. Daily use can form a natural protective film for women to prevent the invasion of candida, trichomonas vaginalis and various harmful bacteria and viruses, thus greatly reducing the infection of vaginitis, metritis and pelvic inflammatory disease.

If it is used daily, women can also use it, because arginine can be quickly converted into nitric oxide in the body, which can dilate tiny blood vessels, increase blood volume and circulation, and help ovulation function, so it can solve and improve women's problems-

Menstrual disorders: uterine fibroids, ovarian cysts and breast tumors are actually related to menstrual disorders and lutein deficiency;

2. Primary dysmenorrhea: it can relax the spiral artery of endometrium and relieve dysmenorrhea;

Improve the success rate of infertility: it can enhance the physiological function of ovary and uterus and improve the implantation rate of fertilized eggs (up to 29%)

Sexual dysfunction: mainly caused by insufficient blood circulation and blood flow. Daily use can increase blood circulation, greatly improve the symptoms of uterine deficiency and cold, and promote the harmony and perfection of husband and wife's sexual life.

5. Vaginal dryness: mainly caused by poor blood circulation and insufficient hormones. A, postpartum vaginal dryness: due to the increase of postpartum prolactin, it will inhibit ovarian hormones; B, after 35 years old, hormones decrease, arteries gradually harden, blood circulation and blood flow decrease, leading to vaginal dryness;

C, after menopause, due to the deterioration of ovarian function, vaginal mucosa shrinks rapidly, causing vaginal dryness; D, after hysterectomy, vaginal dryness is caused by a large reduction of blood circulation from uterine artery.

6. Improve various discomforts of menopause: night sweats, hot flashes, palpitations, insomnia, emotional instability, irritability, depression, anxiety and bone loss.

7, neck beauty: because the ovarian function has improved, the hormones are sufficient, the skin is meticulous, the luster is restored, and it is youthful and beautiful.

8, plastic breast enhancement: because the ovarian function is better, the female hormone function is good, the breast becomes plump and straight, because arginine helps to promote the body's metabolism to become stronger, which is conducive to slimming and degreasing, and is a beautiful line and posture of the body.

Third, daily use can make women delay aging, because arginine can stimulate brain glands to secrete growth hormone after being converted into nitric oxide, which can enhance immunity and delay aging.

Three advantages of men's use

1, improving sleep quality and constipation;

2. Improve sexual function,

3. Prevent and regulate prostatitis.

Interviewee: jerrysias- Scholar II1-1613: 38.

The medicine is still wrong,

Responder: Lily in Water-Auxiliary Level 21-1614:15.

I. What is nongonococcal urethritis? Nongonococcal urethritis is a kind of urethritis transmitted through sexual contact, but gonococcus can not be found in urethral secretions. Women also have reproductive tract inflammation, such as cervicitis. Most pathogens are chlamydia, mycoplasma, trichomonas, herpes virus and candida, and chlamydia and mycoplasma infection account for more than 80%. Urethritis can be divided into two categories, gonococcal urethritis and nongonococcal urethritis. The former refers to urethritis caused by Neisseria gonorrhoeae, and the latter is specific urethritis. The latter refers to urethritis caused by microorganisms other than Neisseria gonorrhoeae, also known as nonspecific urethritis. In this kind of urethritis, the known pathogens are called fungal urethritis and trichomonal urethritis, which are no longer included in nongonococcal or nonspecific urethritis. At present, nongonococcal urethritis usually refers to chlamydia (40%-50%), mycoplasma (20%-30%) and some urethritis with unknown pathogens. & ltB& gt; Second, the pathogen of nongonococcal urethritis Nonspecific urethritis, like gonorrhea, also occurs in the heyday of youth, accounting for 60% under 25 years old. Since the 1960s, the incidence of nonspecific urethritis has risen sharply, surpassing gonorrhea in Europe and America. In the 1980s, there were 300-100000 new cases in the United States every year. (1) Chlamydia According to reports from many countries, 30%-50% NGU, 20% gonorrhea patients and 0.5% people who have strong sexual activity but have no symptoms of urethritis can be cultured from urethral secretions by commonly used culture methods. It is difficult to determine the incidence of female patients, because most of them are asymptomatic or only show gynecological symptoms such as increased leucorrhea. It is estimated that female patients may be four times as many as men. Chlamydia is a microorganism attached to the cytoplasm of glandular epithelial cells. It is spherical and has a special growth cycle. There are two developmental types in each growth cycle. Infectious type is that the basic body is spherical and the size is between bacteria and viruses (300-400mm). Plasmodium can survive outside the cell and is contagious. When it is attached to the surface of susceptible cells, it is swallowed up by cells, and the precursor becomes another reproductive type in the cells. The reproductive type is the original body. The original body is round or oval. Primordium propagates by binary division, and finally begins to recombine into protozoa, which is released from cells and then infects other healthy susceptible cells. The whole growth cycle is 72 hours. Chlamydia classification: 1, Chlamydia psittaci. 2. Chlamydia trachomatis has at least serotype 15. K8 serotype is associated with nongonococcal urethritis. Types L 1, L2 and L33 are associated with lymphogranuloma venereum (the fourth venereal disease). (2) Mycoplasma 1, Ureaplasma-urea is a prokaryotic microorganism. It can produce urease to decompose urea. Stick-shaped. Because it has no hard cell membrane and is not inhibited by penicillin, tetracycline, erythromycin and spectinomycin are effective. At present, seven kinds of mycoplasma have been isolated from human genitourinary tract, among which Ureaplasma urealyticum is the most common mycoplasma, followed by Mycoplasma hominis. Ureaplasma urealyticum can not be found in the reproductive tract of infants or women who have no sexual contact. The more chaotic the sexual life, the higher the positive rate of this mycoplasma. Mc Donald 1982 reported that among 587 patients with symptoms of acute urethritis, 209 cases (36%) were isolated from middle urine. 2. Mycoplasma hominis has weak resistance to external environment and can be killed at 45℃ 15min. Sensitive to soap, alcohol, tetracycline and erythromycin. Chlamydia can not only cause urethritis and conjunctivitis, but also cause inflammation of other reproductive organs, such as epididymitis, spina bifida, cervicitis, vaginitis, salpingitis and pelvic inflammatory disease. Neonates can induce conjunctivitis and pneumonia through infected birth canal. Gay men get proctitis and pharyngitis. & ltB& gt; Third, why the prevalence of nongonococcal urethritis continues to expand: ngu is not easy to be taken seriously because of its slow onset and mild symptoms. The pathogen that causes nongonococcal urethritis can last for several months, and the treatment takes a long time. Patients with complications after irregular medication can carry bacteria for a long time. Not using condoms during sexual intercourse has also caused the growing popularity of nongonococcal urethritis. & ltB& gt; Four. Clinical symptoms and diagnosis (1) Clinical symptoms 1, incubation period of nongonococcal urethritis 10-20 days. 2, the onset is not as urgent as gonorrhea, and the symptoms are delayed, which are light and heavy, but lighter than gonorrhea. About 50% patients have symptoms such as dysuria and urethral itching. It's easy to miss the first visit. Male nongonococcal urethritis is characterized by urethral discomfort, itching, burning or stabbing pain, urethral swelling and swelling, and urethral secretions are mostly serous and thin, and there is a phenomenon of "living" in the morning. Female nongonococcal urethritis is characterized by cervical inflammatory degeneration, increased secretion, mostly lobulated leukocytes (each field of vision is greater than 10 under high magnification), pruritus of vagina and vulva, and discomfort of lower abdomen. Note: Some patients may be asymptomatic or atypical, which is easy to be missed. Multi-lobulated leukocytes in cervical secretion (each visual field is greater than 10 under high magnification). 3, urethral secretion is less, thin, mucinous or mucopurulent. If you don't urinate for a long time (such as in the morning), a small amount of thin secretions can overflow from the external urethral orifice. Sometimes it just means that the scab film blocked the urethral orifice or polluted the underwear in the morning. During the examination, it is necessary to press the anterior urethra from back to front to make a little secretion overflow from the urethral orifice. Sometimes patients have symptoms without secretions, and there are secretions without symptoms. 4, often infected with gonorrhea at the same time. The former showed gonorrhea symptoms first. After anti-gonorrhea treatment, Neisseria gonorrhoeae was killed by penicillin, while chlamydia and mycoplasma still existed. Onset after infection 1-3 weeks. Clinically, it is easy to be mistaken for incurable or recurrent gonorrhea. 5. Improper or untimely treatment can cause complications (1%). Such as acute epididymitis, prostatitis, colitis and pharyngitis. Female cervicitis, cervical erosion, vestibular adenitis, vaginitis, salpingitis, pelvic inflammatory disease, ectopic pregnancy, infertility, etc. 6. Neonatal conjunctivitis can occur through the infected birth canal and 3-13 days after birth, with or without mucinous purulent secretions in the eyes. But it will not invade the cornea. Pneumonia can appear 2-3 weeks after birth. Symptoms are getting worse and worse, showing shortness of breath, but no fever. Half of them have conjunctivitis. 7. A very small number of patients may be accompanied by Lai Fu syndrome: urethritis, arthritis, keratitis, syndrome and rash. (2) Diagnosis of1,history of unclean sexual intercourse, incubation period and symptoms. 2, urethral secretion smear culture, eliminate gonococcal, candida and other bacterial infections. There are a lot of white blood cells in the smear, 10- 15 /400 times or more, and 5/1000 times or more. 3, urethral secretions or cervical scraping, monoclonal chlamydia fluorescent antibody examination or culture. Specimen collection method: The male does not urinate for more than 2 hours, the cotton swab is inserted into the urethra for 2-4cm, gently rotated for 5s, left for 2-3s, and then taken out for culture. Women fully expose their cervix with a speculum. The first swab wipes off the secretions on the surface of the cervix. The second swab was inserted into the cervix 1-2cm, rotated 10s, and stopped for 2-3s. Take out the cotton swab and don't touch the vaginal wall. & ltB& gt; 5. What are the complications of nongonococcal urethritis? Male: epididymitis, prostatitis, seminal vesiculitis. Chlamydia can also affect sperm motility and cause sexual dysfunction. Female: acute and chronic salpingitis, ectopic pregnancy, infertility, abortion, stillbirth. & ltB& gt; Sixth, the judgment of treatment and cure standards After the diagnosis of nongonococcal urethritis, broad-spectrum antibiotics were used, and it was emphasized that the drug should be continuously used and treated regularly, quantitatively and thoroughly. 10-20 days after treatment, all turned negative again, and the clinical symptoms disappeared as a cure. The treatment of this disease requires a long course of treatment. (1) 1. At present, many strains are resistant to tetracycline, doxycycline and erythromycin. A new generation of synthetic antibacterial drugs quinolones are not only effective against chlamydia and mycoplasma, but also highly sensitive to Neisseria gonorrhoeae. (1) norfloxacin 200mg, 3/d *** 14d. (2) fluocinolone 200 mg, 14d, twice /d * *. (3) ciprofloxacin 250 mg, 14d is 2/d * *. 2. Sulfonamide and rifampicin are effective for chlamydia, but not for mycoplasma. 3. Gentamicin, neomycin and polymyxin are ineffective against chlamydia. 4. Streptomycin and spectinomycin are ineffective for chlamydia, but effective for mycoplasma. 5. Tetracycline 0.5g, 4/d, * * used for 7d, changed to 0.25g, 4/d, * * used for 14d. 6. Doxycycline 0. 1g, twice a day, * * * 7 days. 7, erythromycin stearate 0.5g, 4 times /d, * * * for 7 days. 8. Erythromycin ethylsuccinate 0.8g, 4 times /d, * * * for 7d. 9, minocycline immediately 0.2g, 0. 1g, twice /d, * * * same as 14d. (two) to determine the cure standard of treatment should be followed up for a week. Cure criteria: 1, clinical symptoms disappear 1 week or more, there is no secretion in urethra, or the number of white blood cells in secretion is ≤4/100 times microscope. 2, urine clarification, sediment microscopic examination is negative. 3. Chlamydia and Mycoplasma in urethral (cervical) specimens are negative (conditional). & ltB& gt; 7. What problems should I pay attention to after suffering from nongonococcal urethritis? During the treatment, drinking, fatigue and staying up late for sex are forbidden. When one spouse is infected, both parties should check and treat at the same time. Don't wash your genitals with towels or washbasins, and don't mix your underwear. If there are babies at home, articles and hands should be strictly disinfected to prevent transmission through close contact. Using condoms in sexual life can reduce the spread of nongonococcal urethritis.

A, tetracycline 500 mg, 4 times a day, at least 7 days, usually 2 ~ 3 weeks, can also be changed to 250 mg after 7 days, 4 times a day, to 2 1 day. 2. Doxycycline 100 mg, taken orally twice a day for 7 days to 14 days. Three, minocycline (minocycline) 100 mg, twice a day, for 7 days to 14 days. IV. Oxytetracycline 250 mg orally, four times a day for 7 days to 14 days. Five, ofloxacin 200 mg, two to three times a day, for 7 days to 14 days. Six, roxithromycin 150 mg, oral, twice a day, a total of 7 days. Seven, azithromycin 1 gram. Eight, erythromycin 500 mg, oral 4 times a day, even for 7 days. Neonatal conjunctivitis or pneumonia, 50 mg/kg daily, 4 times orally, 10 to 14 days. Children's weight > > according to the adult dose, 45 kg, weight less than 45 kg, 50 mg/kg per day, taken orally four times, for 10 to 14 days. Nine, the traditional Chinese medicine Shuanghuanglian powder injection 60 mg/kg per day, add 500 ml of normal saline intravenous drip, 65438 0 times a day, 65438 00 days in a row.

Non-gonococcal urethritis is completely curable, but it should be treated regularly. Pathogens should be treated, and broad-spectrum antibiotics should be used if conditions do not permit. Gopla found in clinic that the therapeutic effect of broad-spectrum antibiotics is getting lower and lower because of drug resistance.

Cure criteria: asymptomatic disappearance, no urethral secretion, and no white blood cells in urine sediment smear.

Common western medicines for treating nongonococcal urethritis are:

(1) tetracycline 0.5g each time, 4 times a day, at least 7 days. Usually 2-3 weeks. Or tetracycline mixture (composed of three kinds of tetracyclines, each tablet contains 69mg of norchlortetracycline hydrochloride, chlortetracycline hydrochloride 1 15.5mg, tetracycline hydrochloride115.5 mg)1~ 2 tablets, taken orally, twice a day, with a course of treatment of 2 ~. Tetracyclines have teratogenic effects on pregnant women and should be banned.

(2) Take doxycycline 0.2g orally for the first time, and then take doxycycline 0. 1g twice a day for 7- 10 days.

(3) Azithromycin 0.5g for the first time, then 0.25g for each time, daily 1 time, * * * 5 days. Or 1g, take it at once.

(4) Minocycline (minocycline) 0.2g immediately, 0. 1g each time, twice a day, * * * for 7 ~ 10 days continuously. Some patients experienced dizziness, palpitation, epigastric discomfort, nausea and vomiting after taking it.

(5) Erythromycin: 0.25g-0.5g orally, 3-4 times a day, 7- 10 days in total.

(6) Roxithromycin 0.3g each time, daily 1 time, for 7 days. Or 0. 15g each time, twice a day, * * * 7 days. There are 7% patients with side effects.

(7) Erythromycin stearate 0.5g each time, 4 times a day for 7 days.

(8) erythromycin ethylsuccinate 0.8g each time, 4 times a day, for 7 days.

(9) Oxytetracycline 250mg, 4 times a day, for 7 days.

(10) ofloxacin: 200mg-300mg orally, twice a day, 7- 14 days. Ofloxacin injection can also be given intravenously, but not too fast.

(1 1) norfloxacin 200mg, three times a day, * * * for 14 days.

(12) ciprofloxacin 250-400mg twice a day for 7- 14 days.

(13) Oral anti-inflammatory therapy with Telite (erythromycin antibiotic).

(14) Carbendazim (ceftriaxone) 0.25- 1g diluted and then injected intramuscularly or intravenously.

(15) Xianfeng No.5 (cefazolin sodium): 2-6g intramuscular injection or intravenous drip after balanced release.

(16) spectinomycin: 2g for male and 4g for female, once intramuscular injection.

(17) ciprofloxacin: 250-500mg orally, twice a day. Intravenous drip is acceptable. It is not suitable to use with tea-shouting medicine at the same time.

(18) Tylenol 0.2g each time, twice a day for 7 days.

We should follow the principle of timely medication and regular medication, and choose the corresponding antibiotics according to different situations. Sulfonamide and rifampicin are effective for chlamydia, but not for mycoplasma. Gentamicin, neomycin and polymyxin were ineffective against chlamydia. Streptomycin and spectinomycin are ineffective against chlamydia, but effective against mycoplasma. Pregnant women and children should not use tetracycline, doxycycline and quinolones, but erythromycin can be used. In case of gonorrhea and nongonococcal urethritis, penicillin and chlorpromazine should be used first. At present, many strains are resistant to tetracycline, doxycycline and erythromycin. A new generation of synthetic antibacterial drugs quinolones are not only effective against chlamydia and mycoplasma, but also highly sensitive to Neisseria gonorrhoeae. In a word, tetracycline and erythromycin are the main drugs to treat nongonococcal urethritis, while azithromycin and minocycline are the commonly used drugs to treat this disease in recent years. Their curative effect is higher than tetracycline, and the effective rate is about 90%. Experience in treating this disease varies from place to place in China. Oral medication at the same time, should be local external use "Jieeryin" or "Fukang" lotion and other traditional Chinese medicine cleaning, medication on time, so as to avoid complications.

Non-gonorrhoea focuses on aftercare. From my experience, we should avoid anxiety and fatigue, pay attention to adequate sleep and avoid alcohol, tobacco and spicy food. The treatment of this disease requires a long course of treatment, and patience is the most important. If the treatment effect is not good, we must find out the reason. If it is caused by drug resistance, it is necessary to change to another drug treatment. If a sexual partner has the same disease, the curative effect is not good without treatment.