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It's almost summer It's time to lose weight. Is there any good way?
Sibutramine Hydrochloride Capsules (Qumei)

Character; Role; letter

This product is a capsule, and its contents are white or white-like powder.

pharmacological action

This product is the main therapeutic drug for obesity. Its main mechanism is to inhibit the reuptake of norepinephrine, serotonin and dopamine and enhance satiety, but it has no obvious effect on the release of norepinephrine, serotonin and dopamine. The study also showed that this product and its amine active metabolites had no obvious anticholinergic, antihistamine and monoamine oxidase inhibitory effects.

Absorption, distribution and elimination: It is reported that sibutramine hydrochloride is absorbed rapidly in digestive tract after oral administration. The peak time of plasma concentration was 1.2 hours, the oral clearance rate was 1750L/h, and the half-life was 1. 1 hour. The average dose can absorb 77%. Sibutramine hydrochloride passes through the first-pass effect of liver. In vitro experiments show that the drug can be quickly and widely distributed in tissues, and the highest concentration is to remove organs: liver and kidney. About 85% (68-95%) of the radiation dose after a single dose is excreted through urine and feces.

indicate

Sibutramine hydrochloride is suitable for obesity treatment of diet control, exercise failure and weight control, including weight loss and weight loss maintenance. Treatment should be combined with low-calorie diet and exercise. It is suggested that obese patients with body mass index ≥ 30 ㎏/m2 or ≥ 27 ㎏/m2 (accompanied by other risk factors such as hypertension, diabetes, dyslipidemia, etc.) should be treated. ).

dosage

The recommended starting dose is 10mg once a day, which can be taken alone or with food in the morning. If the weight loss is insufficient, the dose can be adjusted to 15mg per day after 4 weeks. If the patient cannot tolerate the dose of 10mg, it can be reduced to 5mg. Dose should be adjusted according to the patient's blood pressure and heart rate. Doses exceeding15mg/day are not recommended.

Suitable for people-simple obesity

Simple obesity (nutritional obesity)

The following people should not bring Qumei:

1, patients treated with monoamine oxidase inhibitor (MAOI);

2. anorexia nervosa;

3. Pathological obesity: such as Cushing's syndrome and hypothyroidism;

4. Hypertensive patients with uncontrolled and poorly controlled blood pressure, patients with coronary heart disease, heart failure, arrhythmia and stroke;

5. Patients with severe liver and renal insufficiency;

6. Pregnant, lactating and pregnant women;

7.1children under 6 years old and elderly people over 65 years old are not recommended;

8. People who are allergic to this product.

The following people should use Qumei with caution:

1, patients receiving 5-HT drugs;

2. Patients taking drugs containing norephedrine, ephedrine and pseudoephedrine;

4. Patients with high myopia and retinal detachment;

5. Patients with cholelithiasis;

6. Patients with angle-closure glaucoma;

7. Those with a history of epilepsy;

8. Patients with menstrual disorders.

Suggestions when combined with some drugs:

1. The following drugs cannot be taken with trimetazidine at the same time, and can only be taken two weeks after stopping using them. Similarly, the following drugs can only be taken after two weeks of stopping trimetazidine:

1) monoamine oxidase inhibitors: phenelzine, propargyl amphetamine, etc.

2)5- hydroxytryptamine drugs: phenoxypropylamine, trifluroxime, florfenicol, sertraline, venlafaxine, etc.

3) Selective serotonin reuptake inhibitors or some drugs for treating migraine: succinate, dihydroergotamine, hexamethylenetetramine dextran, Demerol, serotonin, fentanyl, lithium preparation or tryptophan;

4) Central appetite suppressants: Fenfluramine, Moindor, etc.

2. Be careful when using the following drugs at the same time, and it must be carried out under the guidance of a doctor. We suggest that it is best not to use it together with trimethoprim: phenylpropanolamine, ephedrine and pseudoephedrine.

3. When the following drugs are combined with trimethoprim, it is necessary to carefully observe the physical changes and consult a doctor at any time if necessary: ketoconazole and erythromycin.

4. It is recommended not to consume too much alcohol when taking trimethoprim.

Packaging10mg×10× 3 tablets/box, valid for 2 years, protected from light and sealed.

★ The following information is provided by Qumei manufacturer ★

Qumei's weight loss mechanism;

Double fat control, control fat into the mouth and promote fat consumption.

(1) Burning excess fat:

By inhibiting norepinephrine reuptake, activating adrenergic β3 receptor, increasing lipid

The energy consumption of adipose tissue accelerates the metabolic rate of fat and decomposes excess fat in the form of heat production;

(2) control calorie intake;

By inhibiting the reuptake of 5- hydroxytryptamine, the satiety of human body is increased, and the normal intake of human body is not affected.

Necessary nutrients can effectively control the intake of excess calories on the premise of meeting the normal physiological needs of the body.

Qumei's weight loss has the following six characteristics:

1, lose weight, significantly improve the waist-arm ratio, and have a more delicate figure curve;

2. Reduce subcutaneous and visceral fat and improve blood lipid status;

3. Gradually lose weight and maintain the weight loss effect for a long time;

4. Not relying on diet control, the rebound rate is low;

5. It is safe and can be taken for a long time;

6, powerful and convenient, one pill a day.

How to take tramadol correctly;

Qumei has been sold in China market for nearly six years, and tens of millions of consumers have personally experienced Qumei's weight loss effect. In the process of providing services to consumers, we summarized some basic methods of taking Qumei.

Next, please read the correct way to take Qumei carefully.

1, the recommended dosage is 1 time per day, 10mg once, taken alone in the morning.

2. sensitive person can be taken at or after breakfast.

3, can not be taken after lunch or dinner; As this product is valid for 1 1 hour, if taken after lunch and dinner, it will slightly affect the sleep of some users due to fever, dry mouth and other reasons.

4. Slimming people who are very sensitive to this product may have fever, sweating, dry mouth and constipation. This is a normal reaction to burning fat, but it is transient and can disappear in a short time, which has no impact on health; Sensitive person's recommended administration method is: take it for 2-3 days, stop taking it for 2-3 days, take it for 2-3 days again, and repeat it for 2-3 times, which can eliminate it well.

5. Maintain a normal diet when taking trimethoprim; Qumei has the effect of burning fat, which is different from other slimming products to induce dieting and lose weight. If you overeat while eating Qumei, it may cause hypoglycemia and make people feel short-lived, weak and dizzy. Therefore, pay special attention: you must eat normally when taking this product.

6. If the weight loss is not obvious, the dose can be increased to15 mg; Every day after 4 weeks; If the patient can't tolerate the dose of 10mg/ day, it can be reduced to 5mg/ day; Doses exceeding15mg/day are not recommended.

7. After taking this product to lose weight successfully, please keep good living habits.

Qumei's "30-20- 10" scientific diet;

Qumei's "30-20- 10" slimming method is 30 minutes of aerobic exercise every day+20% reduction of calorie intake every day +65438+ 0 tablets of Qumei every day +00 mg.

30 minutes of aerobic exercise every day, such as:

1, running, playing badminton, swimming, climbing stairs, etc.

2. Try to stand for a while or take a walk after a meal to speed up consumption and avoid sitting or sleeping immediately;

It's best to choose a convenient exercise form that you can stick to yourself.

Reduce your calorie intake by 20% every day:

In fact, it is not difficult to do this, such as eating less snacks, drinking less drinks, eating less rice or two, paying special attention to not having too much, too oily and too full dinner, and trying not to add meals before going to bed.

1 tablet per day 10 mg of tramadol: Take one tablet in the morning, and the weight loss effect lasts for a whole day, and you can continue to consume fat regardless of sitting, lying or walking; Qumei can help develop good eating habits and improve the efficiency of exercise fever. Proper exercise and reasonable diet can get twice the result with half the effort.

Warm reminder:

1. When taking trimethoprim, because it accelerates the burning of fat and the loss of water in the body, normal physiological phenomena such as dry mouth may occur. You should drink more water and eat more vegetables to help speed up metabolism. (See Qumei's correct service method for details)

2. If you really can't control your "mouth" and "legs" for various reasons, eating Qumei alone can also achieve the ideal slimming effect.

The Effective Process of Qumei:

The results of this study are based on obese people with body mass index above 25, which should be in February-March. For dieters whose obesity index is less than 25 during the weight loss cycle, the course of treatment is from 1 to February.

The first stage: preparation period

The preparation period is within 2 weeks after starting medication. At this stage, a few people can achieve a good weight loss effect, and most people lose about 3% of their basic weight. During the preparation, some people may have dry mouth, constipation, insomnia and so on. This is a normal phenomenon in the early stage of taking Qumei, which is transient. Most of them can disappear in a week or so, and a few people may last for a while. Dry mouth and constipation can be relieved and eliminated by drinking water or eating more fruits and vegetables.

The second stage: the onset period

The effective period is 2-4 weeks after taking the medicine. At this stage, more than 90% people have lost weight to varying degrees, and the weight loss can reach 3-5% of their body weight. Some drug addicts can achieve significant weight loss (more than 5%) at this stage. At this stage, if the weight loss effect can't reach the above goal, you can still take it for two months to achieve the goal of losing weight. At this stage, the waist circumference, hip circumference and abdominal circumference have all improved, and the waist-hip ratio has decreased.

Stage III: Validity Period

The effective period is 4-8 weeks after taking the medicine. At this stage, more than 90% people have achieved remarkable weight loss effect, losing more than 5%, and more than 40% people can lose more than 10%. Most people have achieved satisfactory weight loss results. Waist circumference, hip circumference and abdominal circumference are obviously improved, waist-hip ratio is obviously reduced, the ratio of both sides is more symmetrical, snoring is obviously reduced, and the quality of life is obviously improved.

The fourth stage: consolidation period

According to clinical research and the experience of most drug addicts, the consolidation period of weight loss effect is from the third month (9- 13 weeks). We observed that 90% of people who took the drug for 3 months stopped taking it for half a year without rebounding.

According to foreign applications, SDA has approved that tramadol can be taken for a long time to maintain the weight loss process, and it is recommended to take 90 tablets every year. It can be taken in any season according to its own situation, and can prevent obesity and its complications.

Qumei+exercise+diet control:

In an experiment involving 605 subjects (body mass index between 30 and 30-45 kg/m2), diet was given first (depending on basal metabolic rate) and 10mg tramadol was given every day. The experiment was non-blind and lasted for 6 months. They were also asked to adjust their behavior and walk for an extra 30 minutes every day. Patients see a dietitian once every two weeks, and adjust their diet with the change of basal metabolic rate in the third and sixth months. Of all the patients, 106 people withdrew from the trial for various reasons, including unexpected reasons. Among the remaining 499 patients (82%), 467 people lost more than 5% (no weight loss or only slight recovery), and they continued to conduct a randomized double-blind trial of tramadol 10-20mg(352 patients) and placebo control (1kloc-0/5 patients) for a period of/. In half of the drug groups, the dose of trimethoprim eventually increased to 20 mg per day (unapproved dose). Among the 204 patients treated with tramadol and 57 patients treated with placebo, more patients treated with tramadol reached the clinical end point and maintained 80% or more of their original weight loss (43% for the former and 65,438+06% for the latter). The average weight loss of trimethoprim group was also higher (LOCF analysis showed that the former was 10.2kg, while the latter was 4.7kg, the former was 8.9kg and the latter was 4.9kg). Therefore, in the initial 605 subjects, 77% of the patients lost more than 5% of their weight, and in each subgroup, 25% of the patients in the drug treatment group (89 out of 352) and 8% of the patients in the placebo group (9 out of115) maintained their initial 80% weight loss.

In another clinical trial, among 205 obese patients (body mass index > 30kg/m2), 160 people lost more than 6kg through an extremely low-calorie diet (220-800kcal per day for 4 weeks), and then they were randomly divided into tramadol10mg daily group and placebo group. During this year, they also received dietary guidance, but there were no special restrictions. At the end of the study (using LOCF analysis), patients who received trimethoprim therapy lost more weight (5.2 kg on average, compared with 0.5 kg in the placebo group), and most of them (74%, compared with 465,438+0% in the placebo group) maintained at least 65,438+000% of the weight loss caused by extremely low-calorie diet.

Qumei-lose weight:

NICE concluded that tramadol can be used as a part of the whole weight loss plan for nutritional obese patients (no more than 1 year). These patients tried to adjust their diet, exercise and behavior in the past. They were between 65,438+08-65 years old, with body mass index greater than or equal to 27 kg/m2 and significant comorbidity factors, or with body mass index greater than or equal to 30 kg/m2 but no comorbidity factors.

In a 24-week study, 10-30mg tramadol was taken daily, including 1047 obese patients (body mass index between 30 and 30-40 kg/m2). In the placebo-controlled trial, all patients were given a low-calorie diet (male 1500 kcal, female 1200 kcal). Among the 65% patients who completed the trial (66% in the drug treatment group and 59% in the control group), the patients who were given 10mg a day lost an average of 6. 1% of their initial weight, while the patients who were given 15mg a day lost 7.4% (the control group was1.. Using LOCF analysis, the average weight loss of tramadol 10mg group was 4.7%, and that of tramadol 15mg group was 5.8% (0.9% in control group).

Another study on tramadol included 565,438+00 patients (body mass index between 27 and 27-40 kg/m2). During the recruitment period, they received a two-week single-blind placebo treatment and were asked to have a diet control. 485 patients were asked to continue to control their diet (no formal diet control) because they thought they could accept the advice, and were randomly divided into 10mg sibutramine group, 15mg trimethoprim group and placebo group for one year. Only 53% of patients completed the trial (55% in tramadol group and 49% in placebo group). Using LOCF analysis, the patients who used 10mg and 15mg tramadol lost 4.4kg(5%) and 6.4kg(7.3%) respectively (compared with 1.6kg( 1.8%) in the placebo group).

Clinical trials in Ruijin Hospital of Shanghai Second Medical University, Affiliated Hospital of Shandong Medical University, Second Affiliated Hospital of Chongqing Medical University and General Hospital of Tianjin Medical University show that 10mg/ day is effective after 4 weeks, and 12 weeks enters a stable treatment period, with an average weight loss of 7 kg in 24 weeks and an average weekly weight loss of 0.5 kg in the initial stage of treatment, which meets the requirements of FDA for healthy weight loss. Most dieters are satisfied with the weight loss effect.