Creatinine is a metabolite in human body. Once the kidney is damaged, creatinine can not be excreted normally, and the increase of creatinine is also an inevitable trend. In order to let everyone know the harm of high creatinine, here is a detailed explanation for everyone. 1, causing imbalance of water, electrolyte and acid-base balance in the body. These phenomena usually occur when kidney damage is mild, and patients will show symptoms of kidney diseases such as fatigue, polyuria, edema and hyperkalemia. 2, the impact on the digestive system In general, patients with high creatinine will have an impact on the digestive system when the condition worsens, and patients will have symptoms such as anorexia, nausea, vomiting and even diarrhea. 3. High creatinine in the cardiovascular system will also affect the cardiovascular system, which may cause symptoms such as heart failure, myocardial injury or renal anemia. 4, the impact on the respiratory system When the kidney is seriously damaged and acidosis occurs, the patient will show deep and long breathing, and the exhaled gas has a strong ammonia smell. 5. Patients with nervous system are often accompanied by nervous system diseases, such as memory loss, dizziness, headache and other symptoms. In severe cases, symptoms such as irritability, cold expression, coma and lethargy may occur.