Who can't eat dhea What are the side effects of eating dhea? Who can't eat dhea What are the side effects of eating dhea? sage
From the19th century to the early 20th century, doctors determined that people with polycystic uterine fibroids should not take DHEA. It is impossible for any drug to treat only the symptoms, not the root cause, but the degree is different. So what are the side effects of eating dhea?
The first is to increase women's facial hair, because after taking dhea for a long time, the male hormones in women's bodies increase, which in turn makes women appear some male surface characteristics. Second, it affects the supplementary absorption of other drugs and nutrients. Long-term use of dhea may affect the body's absorption of other drugs or nutrients, thus leaving other diseases untreated and the body unable to protect itself.
Limitation and insecurity of DHEA
The limitations of DHEA and the quantitative standards used by different races are difficult to control?
Although DHEA can affect human hormones, the quantitative standards are different for different constitutions and races, so it should be used with caution.
1992, American research found that the main biochemical change caused by DHEA in liver was hepatocyte peroxisome proliferation, which was consistent with the change caused by peroxisome proliferators. In order to further confirm this point, liver tissue was taken from male rats after taking DHEA for two weeks and compared with liver changes caused by peroxisome proliferators. It was found that the liver weight of experimental animals increased by 200% and the density of peroxisome increased by 5 times. Gel electrophoresis showed that the content of a polypeptide with molecular weight of 80 000 in the nucleus of liver homogenate increased significantly. The analysis showed that the content of MRNA encoding peroxidase increased significantly after 24 h ...
These changes are consistent with those caused by peroxisome proliferators. Because peroxisome proliferators usually have carcinogenic activity, it is suspected that DHEA may have carcinogenic activity.
Since then, the American Endocrinology Society, the American College of Obstetrics and Gynecology, the American Society of Reproductive Medicine, the European Endocrinology Society and the International Postmenopausal Society have jointly appointed a working group to reevaluate the published factors affecting fertility, and issued the treatment guidelines for the compound pregnancy repair factor DHEA AMH. Significance analysis of DHEA AMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.
In 2000, the European Union proposed for the first time that in addition to drugs, it should also help women with healthy natural pregnancy and test tubes in plant extraction. Subsequently, the United States also proposed to cooperate with the European Union to study how to assist in vitro fertilization and natural conception. The American Endocrinology Society and the American College of Obstetrics and Gynecology jointly appointed a working group to consider women's natural pregnancy and test tubes from a multi-dimensional and multi-system perspective.
Success and embryo quality problems, the treatment guidelines of compound pregnancy repair factor DHEA AMH were released.
Compound Pregnancy Repair Factor DHEAAMH—— Guidelines for Multi-system Treatment
Natural pregnancy \ test tube-how to have a healthy environment for the implantation of eggs and embryos?
Significance analysis of DHEA AMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.
Female conception is a physiological process in which sperm and eggs meet and reach the uterus.
(1) First of all, the internal and external reproductive systems develop normally to ensure normal sexual life, and the fallopian tube has good functions of taking eggs, transporting eggs, fertilizing and transporting fertilized eggs to the uterine cavity.
(2) The hypothalamus-pituitary-ovary function of female endocrine axis is normal, mature follicles are discharged, corpus luteum is formed, and the function is sound.
(3) Periodic changes in the proliferative and secretory phases of endometrium are beneficial to the implantation of fertilized eggs, and any abnormality in these links will lead to pregnancy disorders.
There are many factors that constitute female fertility disorder, and these factors may coexist in most cases, so we need to solve not only the main reasons, but also other secondary reasons. Only in this way can we get closer to the goal of pregnancy.
What are the factors that lead to female fertility disorder?
1, Ovulation dysfunction: It is characterized by anovulation in menstrual cycle, or ovulation, but luteal function is not perfect after ovulation.
2, ovarian factors: ovarian hypoplasia, luteal insufficiency, egg failure, polycystic ovarian tumors and other factors that affect follicular development or egg excretion will cause.
3, fallopian tube factors: fallopian tube is too long or narrow, tubal inflammation causes lumen occlusion, water accumulation or adhesion, which can hinder the operation of sperm, eggs or fertilized eggs.
4, cervical lesions: congenital abnormalities, atresia or stenosis, erosion, adhesion and so on. May affect the passage of sperm; The existence of anti-sperm antibody in cervical mucus is not conducive to sperm penetration into cervical canal or to complete sperm failure.
5. Factors of endocrine disorders. In addition to abortion, the use of drug abortion will also break the physiological cycle of women, make the endocrine system disorder, make the normal menstrual cycle disorder, and affect normal ovulation.
6, caused by people. Bacteria can easily enter the uterine cavity with surgical instruments, and then infect the fallopian tubes, which can easily lead to salpingitis, fallopian tube obstruction and long water accumulation, and then cause fallopian tube obstruction, so that fertilized eggs can not enter the uterine cavity through the fallopian tubes to conceive, thus losing the chance of natural delivery.
7. Severe reproductive infection. Because we don't pay attention to self-protection in our life, we often get infected, which makes trouble for later childbirth.
Compound pregnancy repair factor DHEAAMH-egg quality and quantity regulation system
Egg quality and quantity regulation system-supplementing ovarian nutrition and repairing ovarian function
Significance analysis of DHEA AMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.
The age of first childbearing is getting later and later, and more and more elderly women are considering giving birth. However, it is an indisputable fact that the fertility of older women declines, so that the number of patients with decreased ovarian reserve function increases year by year, which makes the proportion of patients with controlled ovarian hyperstimulation in IVF-ET increase significantly. It is estimated that 5%- 18% of the test tube cycle ends with low ovarian response. However, poor ovarian response will lead to less follicular recruitment and low egg acquisition, especially the small number of high-quality eggs and high cycle cancellation rate, which will seriously reduce the pregnancy rate and become one of the difficult problems in the field of assisted reproduction.
Ovarian reserve function refers to the ability of ovarian cortex to form fertile oocytes, which is mainly determined by the number and quality of antral follicles in ovary. For the decline of ovarian function, people have tried various schemes, but they have not achieved ideal results. In 2000, the European Union and other organizations first reported the application of DHEA AMH to a group of infertile elderly women with unexplained complications. After the first application of DHEA AMH, the level of insulin-like growth factor in patients' blood increased, thus improving the recruitment and development of follicles. Subsequently, the role of DHEA AMH in the reproductive field was studied for several years, and it was considered that DHEA AMH can mainly improve the ovarian environment, repair the ovary, provide nutrition for the ovary, increase the number of fertilized eggs and embryos, and increase the number of oocytes and embryos.
The incidence of aneuploidy in embryos produced in vitro was evaluated. These embryos came from 27 ovulating women who underwent continuous extracorporeal cycles, and these women also received preimplantation genetic diagnosis (PGD). During these cycles, 19 patients did not receive DHEAAMH treatment when they entered the test tube, and 8 patients received DHEAAMH supplementation at least 4 weeks before the test tube started.
DHEAAMH treatment can increase the number of higher oocytes from about 8.5 to about 10.4. In this case, there is no significant difference in the absolute number and percentage of diploid embryos after DHEAAMH, but there is no significant difference between untreated and treated patients. With the increase of women's age, the rate of embryo aneuploidy will drop sharply. Therefore, the increase of aneuploidy results in elderly women is an important evidence of the effectiveness of DHEAAMH in improving embryo quality. Pretreatment with dehydroepiandrosterone for women with ovum failure can significantly increase their chances of transplanting at least one aneuploid embryo.
Compound pregnancy repair factor DHEAAMH- premature ovarian failure improvement system
Premature ovarian failure improvement system-providing backup guarantee for oocyte quality
Significance analysis of DHEA AMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.
In this survey, the infertility rate of premature ovarian failure and abnormal ovarian function is 0. 1%, but the clinical manifestations of premature ovarian failure are high FSH level and amenorrhea. The occurrence of premature ovarian failure seriously affects women's psychological state and fertility, causes endocrine disorders, and greatly reduces the probability of pregnancy.
When a woman is born, there are about 2 million follicles in the ovary, but only 400-500 follicles eventually mature, and most of them will die with age. The phenomenon is the decline of ovarian function, the disappearance of ovulation function and the decline of fertility function. Normal women have 65,438+02% eggs in their ovaries at the age of 30, but only 3% eggs remain at the age of 40. In addition to the function of the egg itself will decline with age, when women approach menopause, the menstrual cycle will become more disordered, and the endometrium will become thinner, which is even less suitable for fertilized eggs to implant. At the same time, vaginal discharge is reduced and vagina is dry, which is not conducive to the entry of sperm.
Ovarian stem cells stop proliferation and differentiation after aging, so that ovarian follicular pool can not be replenished, leading to ovarian function decline and ovulation stop. It can be seen that the aging of ovarian stem cells may be the fundamental reason for the decline of ovarian function. Many studies have shown that the proliferation and differentiation of ovarian stem cells are regulated by immune factors (immune cells and immune factors). In this experiment, after DHEAAMH supplementation, compared with the control group, the expression of immune factor protein in high, medium and low dose groups increased significantly, the function of macrophages increased, and the number of follicles increased, which verified that immune function regulated reproductive function, indicating that DHEAAMH could enhance female reproductive function.
The use of dehydroepiandrosterone has a beneficial effect on the quality of oocytes and embryos. The observation that DHEAAMH is related to improving the cumulative embryo score shows that this treatment can improve the quality of embryos and eggs. The strong trend of increasing embryo ploidy and pregnancy rate further supports this suggestion.
The dose of dehydroepiandrosterone is about 65438 03 g/day to about 26 g/day for women. DHEAAMH therapy can be applied to premenopausal women with weakened ovarian function, which has a statistically significant effect on the cumulative embryo score after about 2 months, but its effect can be continuously increased to about 4 months, or about 16 weeks, and can be used for more than 4 months.
The cumulative embryo score of women before using DHEAAMH may be about 34. After continuous use of DHEAAMH for at least about four months, the cumulative embryo score may be at least about 90, and the cumulative embryo score may increase by at least about 64. There was significant difference in cumulative embryo score before and after treatment with dehydroepiandrosterone (P
Ovarian reserve reduces the number of female aneuploid embryos and embryo transfer. Pretreatment with DHEAAMH for at least about 65438 0 months, preferably at least about 4 months, can increase the number of oocytes and embryos, the quality of eggs and embryos, the cumulative pregnancy rate, IVF rate and pregnancy time in women.
Compound pregnancy repair factor DHEAAMH-uterine injury repair system
Uterine injury repair system-providing high-quality space for egg number and embryo implantation.
Significance analysis of DHEAAMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.
In this study, the endometrial damage of infertile patients was 4 1.4%. The uterine environment is very important, because it is related to embryo implantation and is one of the key steps of in vitro fertilization-embryo transfer reproductive technology and normal pregnancy.
Old postpartum injury, habitual abortion, sequelae of drug abortion, nutrition of endometrial repair surgery, nutrition of uterine and cervical surgery rehabilitation, human-uterine abortion, curettage, reproductive injury and involution will all cause uterine injury. Dehydroepiandrosterone contains targeted endometrial repair factors, which have good clinical manifestations on endometrial abnormality, endometrial injury and endometrial inflammation.
Compound pregnancy repair factor DHEAAMH- endometrial repair
1. Epidermal growth factor (EG-F) is distributed in uterine cavity epithelium, glandular epithelium and interstitial cells. ① Stimulate the proliferation of endometrial glandular epithelium and stroma, and differentiate stroma under the synergistic effect of progesterone; ② Receptors acting on the cell surface can quickly stimulate the phosphorylation of compound acid and promote the release of PGE2 _ 2 from endometrium.
2. Platelet growth factor: derived from endometrial stromal cells. It can stimulate the proliferation of interstitial cells themselves and their adjacent epithelial cells, and has autocrine and paracrine functions. PDGF can promote the proliferation of EG-F cells.
3. Insulin-like growth factor: distributed in endometrial epithelial stroma and myometrial cells.
4. Vasoactive substances and angiogenic factors produce growth factors in endometrium.
DHEAAMH can improve the quantity and quality of oocytes and embryos, improve the pregnancy rate in poor uterine environment and reduce the risk of abortion. It can improve the high-quality embryo rate and AMH level of elderly patients with normal ovarian reserve and improve the pregnancy outcome.
The double-blind randomized controlled study found that there was no significant change in ovarian AFC between DHEAAMH supplementation and non-DHEAAMH supplementation, but the number of high-quality embryos increased significantly, probably because DHEA AMH could reduce embryo aneuploidy. After DHEAAMH intervention, the number of primordial follicles, primary follicles and secondary follicles increased significantly, and follicular atresia improved.