Ketogenic diet is the ratio of body fat to carbohydrate. Protein and nutrients in the body can treat childhood epilepsy. Generally speaking, ketogenic diet can reduce the seizure from human hunger, which is also commonly known as hunger therapy. Generally speaking, the ketogenic diet can eat some protein food.

What does the ketogenic diet eat?

Principle and mechanism

To metabolize.

Energy metabolism and ketone body metabolism in brain

When eating, glucose enters the brain by promoting glucose transport carriers. During fasting, fatty acids provide energy for muscles and other tissues, but they cannot enter the brain. Ketone produced by fatty acids and ketogenic amino acids in the liver (ketogenic)

Amino acids (ketogenic) enter the brain through the transport carrier (MCT 1transporter), providing it with another kind of energy. "Ketone" contains three components: acetoacetic acid,

β -hydroxybutyric acid, acetone. Newborns and young children are 3-4 times more likely to produce and use brain ketone bodies than adults.

Ketogenic diet mechanism

Ketogenic diet is a diet with high fat, low carbohydrate and proper protein, which simulates the state of human hunger. Ketones produced by fat metabolism, as another source of body energy, can have anticonvulsant effect on the brain. The specific anticonvulsant mechanism is not clear. It is generally believed that there may be the following aspects.

1, change the energy metabolism of the brain.

2. Change cell characteristics, reduce excitability and buffer epileptic discharge.

3. Change the functions of neurotransmitters, synaptic transmission and neuromodulation.

4. Change the extracellular environment of the brain and reduce excitability and synchronization.

Ketogenic diet

This diet is high in fat and low in carbohydrate, which is suitable for protein and other nutrients. In the last few decades, this therapy has been used to treat intractable epilepsy in children.

The ketogenic diet begins with the observation that hunger can reduce seizures. A long time ago, hunger therapy was used to treat epilepsy, and hunger therapy was mentioned as a treatment for epilepsy.

Absolute contraindication

Carnitine deficiency

Carnitine palmitoyl transferase I or II deficiency

Carnitine transferase Ⅱ deficiency

β -oxidation deficiency

Medium-chain acyl dehydrogenase deficiency

Long-chain acyl dehydrogenase deficiency

Short-chain acyl dehydrogenase deficiency

Long-chain 3- hydroxy acyl coenzyme deficiency

Medium chain 3- hydroxy fatty acyl coenzyme deficiency

Pyruvate carboxylase deficiency