Cause analysis of high 1 creatinine
The causes of many diseases are not single and need to be understood one by one. According to clinical analysis, there are various reasons for the high creatinine. Among them, patients with the original kidney disease will have symptoms such as oliguria and anuria when the disease recurs, and may also be complicated with acute renal insufficiency, leading to an increase in serum creatinine. Others, because of fatigue and poor rest, make the body's immunity decline, which in turn causes a transient increase in serum creatinine. In addition, when the body loses water and has symptoms such as fever and hyperhidrosis, polyuria leads to blood concentration. In this case, the renal blood flow inside the human body will decrease, thus inducing the increase of serum creatinine.
In addition to these, the causes of high creatinine are related to blood pressure, intestinal infection, urinary tract infection and other factors, which need to be solved in time. It is also suggested that people pay more attention to improving the immune function of the body and reducing the probability of illness. Like (Yangshengtang) natural vitamin C tablets, it is a good choice and has the function of improving immunity. However, it should be noted that you should not take too much, which should be subject to the doctor's advice or instructions.
As can be seen from the above introduction, the causes of high creatinine are not uncommon, so people should take precautions in many ways and cannot be ignored, otherwise the probability of kidney disease is still very high. At the same time, on the issue of reducing this value, friends can choose regular hospitals and use scientific treatment programs to reduce the possibility of diseases in life.
2. Analysis of the causes of low creatinine.
There are many reasons for the low creatinine (1), which may be related to anemia, creatinine malnutrition, muscle atrophy, leukemia, diabetes insipidus and other diseases. There is a detection data value called urea nitrogen value in creatinine value, but this urea nitrogen value is easily influenced by many other factors, so it cannot simply reflect renal function. When there is no muscle disease, the value of creatinine is relatively simple and can rise and fall synchronously with renal function. Therefore, when the kidney itself is diseased, urea nitrogen and creatinine rise synchronously, so the ratio of urea nitrogen and creatinine will fall within a certain range (less than 20). If it is a prerenal factor, urea nitrogen tends to rise more, so the value of urea nitrogen/creatinine will be larger (greater than 20).
(2) Creatine in human body is mainly produced by muscle metabolism, and creatinine is excreted by kidney. Under normal circumstances, because the muscle mass of human body is relatively stable, the amount of creatinine produced is also constant, and the level of serum creatinine mainly depends on the amount of creatinine excreted by kidneys. The compensatory function of the kidney is very powerful. If both kidneys are normal, serum creatinine can be maintained at a normal level as long as one kidney functions normally. That is to say, when the degree of kidney damage accounts for more than half of the whole kidney, it will lead to the increase of serum creatinine and low activity. Therefore, serum creatinine can not reflect early and mild renal function decline.
(3) After the kidney is invaded by various reasons, firstly, the damaged intrinsic cells of the kidney undergo phenotypic transformation, which stimulates the fibroblasts in the kidney to be transformed into myofibroblasts, and at the same time invades and stimulates the inherent normal kidney tissue, resulting in the same pathological changes, thus forming the diffusion process of the kidney from point to surface and from local to whole, thus entering the stage of organic injury (that is, the stage of renal function injury). At this time, due to the continuous damage of the kidney, the function of excreting waste is reduced, which leads to the accumulation of toxins such as creatinine in the body, which leads to the increase of creatinine and urea nitrogen in the blood, the decrease of creatinine in the urine and the decrease of renal filtration rate.