2. Zhang Zhongjing (about 150 ~ 154—— about 2 15 ~ 2 19) was born in Nieyang County, Nanyang (now Zhangzhai Village, Gedong Town, dengzhou city City, Henan Province). The famous doctor at the end of the Eastern Han Dynasty was honored as a "medical sage" by later generations. Zhang Zhongjing extensively collected medical prescriptions and wrote the masterpiece Treatise on Febrile Diseases handed down from ancient times. The principle of "syndrome differentiation and treatment" established by him is the basic principle of TCM clinic and the soul of TCM.

3. In terms of prescriptions, Treatise on Febrile Diseases has also made great contributions, creating many dosage forms and recording a large number of effective prescriptions. The therapeutic principle of differentiation of six meridians established by him has been highly praised by doctors in past dynasties. This is the first medical monograph in China to establish the law of syndrome differentiation and treatment from theory to practice. It is one of the most influential works in the history of Chinese medicine, and it is a necessary classic work for later scholars to study Chinese medicine, which has been widely valued by medical students and clinicians.