Pharmacological action: 1. The diuretic effect has been reported. The water extract and alcohol extract of Poria cocos have almost no diuretic effect after being given to rabbits, rats and mice, and the intravenous injection of decoction in dogs with chronic experimental ureteral fistula has no diuretic effect. However, it has also been reported that Poria cocos does have diuretic effect in chronic experiments of conscious rabbits, and it is proved by ash control that its diuretic effect is not due to potassium salt. It is the function of other ingredients besides potassium salt. The hot water extract and water-soluble polysaccharide components of Poria cocos have no obvious effect on normal rabbits. If Poria cocos is compatible with ginger and licorice, the urine volume will increase steadily from 1 hour after administration, and the effect will continue thereafter. Such as chronic nephritis, Poria cocos is combined with Atractylodes macrocephala and ginger. After taking medicine 1 hour, urine output will increase to a considerable extent. It is suggested that compound prescription can produce more lasting effect than single medicine in diuretic effect. The principle of diuresis of Poria cocos has not been clarified. Some people compare Poria cocos ash with 25% Poria cocos alcohol extract, the latter shows diuretic effect, while the former has no effect, indicating that Poria cocos contains special diuretic components. In the experiment of adrenalectomy in rats, the urine volume of 30% Fuling decoction combined with injection of deoxycorticosterone increased, and the urine sodium and potassium excretion also increased. Therefore, it is considered that Poria cocos has no anti-deoxycorticosterone effect, which is related to the influence of renal tubules on sodium ion reabsorption. 2. Sedative effect Fuling decoction can obviously reduce its spontaneous activity and resist the excessive excitement caused by caffeine in mice. It has obvious synergistic effect on the anesthetic effect of pentobarbital sodium. Poria cocos can enhance the central inhibitory effect of thiopental sodium on mice, and the anesthesia time is obviously prolonged. 3. Effects on cardiovascular system In isolated heart perfusion experiments of groundhog, toad and edible frog, the water extract, ethanol extract and ether extract of Poria cocos can enhance myocardial contractility. Heart rate increased. The water extract and alcohol extract of Poria cocos can reduce blood sugar in rabbits. 4. Effect on digestive system Poria cocos has obvious protective effect on liver injury induced by carbon tetrachloride in mice, which can obviously reduce alanine aminotransferase activity and prevent hepatocyte necrosis. Poria cocos extract can directly relax the isolated rabbit intestine and reduce the contraction amplitude and tension of smooth muscle. It can inhibit the ulcer caused by pyloric ligation in rats and reduce the secretion of gastric juice and the content of free acid. 5. Anti-tumor effect Porphyrin itself has no anti-tumor effect. Porphyrin (porphyrin) and carboxymethyl porphyrin have different anti-tumor effects on sarcoma S 180 and ascites transformation in mice, cervical cancer S 14 transformation and ascites transformation. The intraperitoneal administration of porphyrin exceeded 10 mg/kg. It can inhibit the growth of S 180 solid tumor in mice, but has no obvious synergistic effect with anti-tumor drugs such as 5- fluorouracil and cyclophosphamide, and has no direct killing effect on S 180 cells in vitro. It also has a certain inhibitory effect on Ehrlich ascites carcinoma. Experiments show that carboxymethyl pachyman can inhibit the DNA synthesis of Ehrlich ascites cancer cells. Porphyrin has obvious irreversible inhibitory effect on DNA synthesis of mouse leukocyte L12101210 cells, and the inhibitory effect is enhanced with the increase of dose. Porphyrin has synergistic effect on anticancer drugs, and the inhibition rate of S 180 in mice is 48% when combined with mitomycin (35% when mitomycin is used alone). When combined with gentamicin, the tumor inhibition rate was 38.9% (19.6% when used alone). Combined with cyclophosphamide, the tumor inhibition rate was 69.0% (cyclophosphamide alone was 32.3%). Combined with 5- fluorouracil, the tumor inhibition rate was 59. 1%(5- fluorouracil alone was 38.6%). For mouse leukemia L 12 10, the life extension rate of cyclophosphamide alone was 70%, and that of Poria cocos combined with cyclophosphamide was 168. 1%. As for the anti-tumor mechanism of Poria cocos, the experiment proved that the anti-tumor effect of carboxymethyl pachyman was related to thymus. It has also been reported that pachyman activates local complement. Activating the complement in the adjacent area of tumor can kill tumor cells by affecting macrophages, lymphocytes or other cells and humoral factors. The inhibitory effect of carboxymethyl pachyman on Ehrlich ascites cancer cells is achieved by inhibiting DNA synthesis. 6. The other function of Fuling decoction is oral administration. It can significantly improve the rosette formation rate and lymphocyte transformation rate induced by phytohemagglutinin. Pachyman has the effects of resisting thymus atrophy, spleen enlargement and tumor growth, and gastric perfusion can enhance the phagocytosis of macrophages in mice and increase the number of ANAE positive lymphocytes in mice. It can also significantly increase the number of antibody secreting cells in the spleen of mice. Porphyrin can also accelerate the recovery of leukopenia induced by cyclophosphamide in rats. Carboxymethyl porphyrin also has a variety of physiological activities, such as immunomodulation, liver protection and enzyme reduction, indirect antivirus, induction and induction of interferon, reduction of radiation side effects, induction and induction of leukocytes and so on. No adverse side effects. In vitro experiments show that Fuling decoction can inhibit Staphylococcus aureus, Escherichia coli and Proteus. The ethanol extract can kill leptospira, but the decoction is ineffective. 1. Poria skin: the skin of Poria sclerotium, which is beneficial to edema. 2, red poria cocos: the reddish part after peeling, the function of wetting. 3, white poria cocos: red poria cocos, also known as poria cocos, cut into small squares and cut off the white part, which has the effect of moistening dryness and strengthening the spleen. 4, Shen Fu: White Poria center with fine pine roots, cut into square slices, has the function of calming the heart and calming the nerves. 5, poria cocos: spleen and dampness. 6, poria skin: more wet than spleen. Indications: dysuria; A rising tide lifts all boats; Excessive phlegm and cough; Vomiting; Deficiency of spleen and eating less; Diarrhea; Palpitation; Insomnia and forgetfulness; The nocturnal emission is white and turbid.