Syndrome of disharmony between liver and spleen is the interaction of stagnation of liver-qi and stagnation of spleen-qi, and the liver and spleen lose normal coordination. Xiaoyao Powder and Tongxie Yaofang Yaoyao are the best prescriptions for soothing the liver and strengthening the spleen. Syndrome of disharmony between liver and spleen and syndrome of liver-qi invading stomach are both caused by liver-qi invading middle energizer. The spleen and stomach are in the middle focus, belonging to the soil. Therefore, both syndromes belong to Muwangtu, and they may have clinical manifestations such as chest pain, mental depression or irritability. However, the spleen governs transport and transformation, and its qi governs ascending; The stomach governs the reception, and its qi governs the descending, so the syndrome of disharmony between liver and spleen is manifested as both the symptoms of stagnation of liver qi and the symptoms of spleen losing health, such as abdominal distension and diarrhea. Liver-qi invading the stomach, besides stagnation of liver-qi, is often accompanied by epigastric pain, hiccups, belching, noisy acid swallowing and vomiting.