The role of biological species in human body determines people's sleep and awakening. According to the instructions of the brain, the biological clock regulates the functions of various organs in the whole body in a 24-hour cycle.
All animals on the earth have a physiological mechanism called "biological clock", that is, a 24-hour cycle rhythm from day to night, such as a light and dark cycle, which coincides with the earth's rotation once.
The biological clock is controlled by the suprachiasmatic nucleus of the hypothalamus. Like all mammals, the area of SCN in human brain is also above the oral palate. The circadian rhythm of sleep, wakefulness and eating behavior is attributed to the biological clock.
Extended data
The biological clock can regulate metabolism.
There is a cool clock in the human body-biological clock. However, the mechanism of biological clock regulating physiology, metabolism, behavior and other life activities is very complicated, which still needs further exploration. Professor Wang Tian of Nanjing Agricultural University cooperated with the University of Chicago to publish the research results in Cell Communication, revealing the new way of biological clock regulating metabolism.
The biological clock created by genes and protein is a gift of biological evolution. The biological clock controls the rhythm of human daily life: when to sleep soundly and when to wake up refreshed. Long-term biological clock disorder will lead to metabolic diseases such as diabetes, hyperlipidemia and obesity, and even cancer. The 20 17 Nobel Prize in Physiology and Medicine was awarded to three scientists who discovered the world's first biological clock gene.
N6- methyladenine (m6A) is the most abundant post-transcriptional modification in eukaryotic RNA, which plays an important role in gene expression, RNA splicing, mRNA transport and translation. Dynamic reversible methylation modification of m6A is widely involved in mammalian development, immunity, tumor generation and metastasis, stem cell renewal, fat differentiation and other life processes.
In this study, the researchers specifically knocked out the biological clock gene Bmal 1 in mice's liver, and found that the lipid metabolism in mice's liver was abnormal, the level of mRNA m6A increased, and the circadian rhythm was lost.
Through m6A-seq, the researchers found that m6A modification of PPARα, an important gene regulating liver lipid metabolism, increased, suggesting that Bmal 1 affected methylation modification of m6A RNA to regulate the expression of genes related to lipid metabolism, thus regulating lipid metabolism.
Further research confirmed that methylation modification of m6A RNA can affect the stability and longevity of PPARα mRNA through YTHDF2, thus regulating the transcription and translation of PPARα gene and affecting lipid metabolism. This study reveals a new way of biological clock regulating metabolism, and expands people's understanding of the relationship between biological clock, methylation modification of m6A RNA and metabolism.
Baidu encyclopedia-biological clock
People's Network-Revealing a New Way of Biological Clock Regulating Metabolism