The function of platycodon grandiflorum: cough with excessive phlegm and chest tightness. This product can dispel bitter taste, disperse lung and resolve phlegm, and can be used regardless of cold and heat. For people with wind-cold colds, use perilla and almond, such as Su Xing Powder (Treatise on Febrile Diseases); For wind-heat patients, drink it with mulberry leaves, chrysanthemums, almonds and mulberry chrysanthemums (Treatise on Febrile Diseases); For phlegm and blood stasis and chest tightness, it is often used with Fructus Aurantii.
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Expectorant and antitussive effects: Oral administration of this decoction 1g/kg to anesthetized dogs can significantly increase mucus secretion in respiratory tract, and its strength is comparable to that of ammonium chloride. It also has obvious expectorant effect on anesthetized cats. Saponins contained in Platycodon grandiflorum can stimulate the throat mucosa and gastric mucosa to some extent when taken orally, and cause excessive secretion of respiratory mucosa by reflection, thus diluting the sputum and promoting its discharge. The crude platycodon grandiflorum saponin has antitussive effect. The effective antitussive dose of intraperitoneal injection in guinea pigs was 6.4mg/kg. ?
Hypoglycemic effect: oral administration of platycodon grandiflorum water or alcohol extract 200mg/kg can reduce blood sugar in rabbits, and the hypoglycemic curve of water extract is similar to that of metsulfuron-methyl 25 ~ 50 mg/kg. Oral administration of 500mg/kg of water and alcohol extract for 4 days can also reduce the blood sugar of experimental alloxan diabetic rabbits, and the reduced liver glycogen can also be recovered after taking the medicine, and the increase of food blood sugar can be inhibited. The effect of alcohol extract is stronger than that of water extract.
Effects on circulatory system: Rats were injected with crude platycodon grandiflorum saponin intravenously, resulting in temporary blood pressure drop, slow heart rate and respiratory depression. At high concentration, it has negative inotropic effect on isolated guinea pig auricle. Injecting 200 ~ 800 mg/kg crude platycodon grandiflorum saponins into anesthetized dogs can reduce the resistance of coronary artery and Nigerian limb blood vessels and increase blood flow, and its intensity can be comparable to papaverine. Intravenous injection of 4mg/kg can also increase coronary artery and hind limb blood flow, accompanied by temporary hypotension. It is believed that this vasodilation is a direct effect on peripheral blood vessels. ?
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