Damp heat, plus Herba Artemisiae Scopariae and Rhizoma Coptidis; When wet, adding Amomum Tsaoko, Rhizoma Atractylodis and Rhizoma Acori Graminei; Removing Radix Codonopsis and Xu Changqing with yin deficiency, and adding Radix Glehniae and Radix Ophiopogonis; Yang deficiency plus Alpinia officinarum and Aspongopus.
Astragalus membranaceus, Codonopsis pilosula, Xu Changqing, Curcuma zedoaria, hedgehog skin, activating qi and relieving pain, promoting blood circulation and removing blood stasis, Atractylodes macrocephala and Fructus Aurantii, clearing away heat and toxic materials, soothing the liver and regulating the stomach.
Modern pharmacological research shows that Codonopsis pilosula and Astragalus membranaceus can inhibit and correct abnormal cell proliferation and induce precancerous cell death. Drugs for promoting blood circulation and removing blood stasis such as zedoary and hedgehog skin can improve microcirculation, restore pathological changes and absorb inflammation; Dandelion can protect gastric mucosa and inhibit Helicobacter pylori. Hedyotis diffusa can promote the recovery of atrophic glands and reduce or eliminate dysplasia. Therefore, this prescription has a certain blocking and reversing effect on precancerous lesions of gastric cancer.
Chronic atrophic gastritis is a kind of chronic gastritis characterized by atrophy of the proper glands of gastric mucosa. It can evolve from normal gastric mucosa to inflammation, atrophy, intestinal metaplasia, dysplasia to gastric cancer, which has been recognized by everyone, so it has been paid more and more attention in recent years. The common causes may be helicobacter pylori infection, bile reflux, immune factors, genetic factors and so on.
At present, anti-HP, gastric mucosal protection, vitamins and folic acid are commonly used in western medicine, but whether it can be completely reversed is still inconclusive, and there is still a lack of effective methods to block or reverse the disease in clinic.
In traditional Chinese medicine, chronic atrophic gastritis belongs to the category of "stomachache" and "epigastric fullness". This disease often damages the spleen and stomach due to exogenous pathogenic factors, improper diet, emotional disorder, deficiency of spleen and stomach elements, etc., resulting in loss of spleen health, disharmony of stomach, unfavorable middle focal axis and imbalance of qi.
The course of this disease is long, characterized by deficiency of essence, mainly including deficiency of spleen-qi and deficiency of stomach yin, while essence is mainly qi stagnation, damp-heat and blood stasis, and spleen deficiency, qi stagnation and blood stasis are its basic pathogenesis. Among them, blood stasis is the most important pathological factor and the key pathological link of disease occurrence, development and even malignant transformation.