1. 1 antitussive, expectorant and antiasthmatic effects Lycium barbarum snake bile wine can prolong the latent period of cough in mice and reduce the number of coughs caused by ammonia water. Shedan Chuanbei soft capsule can also reduce the number of coughs caused by ammonia water in mice. After heating and sterilizing snake bile, it was found that its biological activity remained unchanged, and it could still reduce the number of coughs caused by ammonia stimulation in mice, showing antitussive effect. Artificial snake gall can also inhibit the cough caused by strong ammonia stimulation in mice and prolong the cough incubation period. Comparative study on pharmacodynamics of artificial snake bile Fritillaria preparation and natural snake bile Fritillaria powder shows that both of them can obviously prolong the cough latency and reduce the number of coughs in mice. It is considered that artificial snake bile can replace natural snake bile to make compound preparation. Shedan Chuanbei soft capsule can improve the secretion of phenol red in trachea of mice and show expectorant effect. Artificial snake gall and artificial snake gall Fritillaria preparation can also improve the secretion of phenol red in the trachea of mice. Shedan Chenpi Capsule can obviously increase the secretion function of bronchial mucosa in mice and rats, and its expectorant effect is similar to that of 2.1g kg-1dose of ammonium chloride. Niuhuang Shedan Chuanbei Capsule can weaken guinea pig asthma induced by histamine and acetylcholine mixture and reduce the number of asthmatic animals. It is also reported that the artificial Fritillaria Serpentis preparation, like natural products, can obviously inhibit the tracheal spasm induced by acetylcholine in isolated guinea pigs and has antiasthmatic effect. 1.2 Anti-inflammatory Lycium barbarum snake gall wine can inhibit the foot swelling caused by carrageenan by continuous gavage in mice. However, the artificial snake gall preparation can obviously inhibit the ear swelling of mice caused by xylene, the foot swelling of rats caused by egg white and carrageenan, and the granulation hyperplasia of rats caused by cotton ball method. It also has a strong inhibitory effect on the increase of capillary permeability in mice caused by acetic acid. However, it was reported by Zhang Dan and others that Fritillaria cirrhosa powder could not inhibit the auricle swelling and ear capillary permeability in mice with xylene-induced inflammation. 1.3 immunomodulation Qiqi snake gall wine can enhance the phagocytosis of mononuclear macrophages in mice, increase the thymus index of mice, and enhance the delayed hypersensitivity of immunocompromised mice, thus enhancing the immune function of the body. Zhang Dan and others also reported Fritillaria cirrhosa. It can obviously inhibit the delayed hypersensitivity induced by 2,4-dinitrofluorobenzene (DNFB) in mice, and can obviously promote the phagocytosis of peritoneal macrophages in immunocompromised mice, indicating that it enhances the nonspecific immune function of the body. Effects of 1.4 on cardiovascular system Hu et al. discussed the effects of artificial snake gall and its main component, sodium taurocholate (TCANa), on the heart and blood pressure of animals. The results showed that artificial snake gall and TCANa could significantly reduce the blood pressure of rats, resist the increase of blood pressure caused by ephedrine, and gradually reduce the contraction amplitude and frequency of isolated frog heart. There is no significant difference between them. However, both of them have no obvious effect on the electrocardiogram of rabbits. Therefore, it is preliminarily considered that TCANa is the main material basis for lowering blood pressure of artificial snake gall. In vitro antibacterial effect of 1.5. The original solution and diluent of Fritillaria Fritillaria Thunb. were 1: 10, and their antibacterial diameters were 24mm and 12 mm, respectively, showing certain antibacterial activity. In addition, the in vitro bacteriostatic test of Fritillaria cirrhosa was also reported. The results showed that the minimum inhibitory concentrations (MIC) of Staphylococcus aureus, Streptococcus hemolyticus type I, Diphtheria, Pneumococcus, Staphylococcus and Candida albicans were 50, 50, 100, 200, 200, 200 g L-1respectively, which indicated that respiratory tract infection was easy to be caused. 1.6 others promote intestinal peristalsis. Shedan Chenpi capsule can promote small intestine movement in mice, and its effect is similar to that of neostigmine in 2.1g kg-1. Anti-visual fatigue. The comparative study on the clinical efficacy of Pearl Snake-gallbladder Mingmu Liquid and Mingmu Oral Liquid in the treatment of asthenopia shows that the curative effect of Pearl Snake-gallbladder Mingmu Liquid group is significantly higher than that of the control group. 2. 1 Clinical application of snake bile, fresh bamboo juice, roasted centipede and raw licorice. 82 cases of infantile bronchitis were treated, 62 cases were cured, 65 cases were improved, and 2 cases were ineffective. The total effective rate was 97.5%. 2.2 Cough 108 Cough due to lung heat was treated with three snake gall, Fritillaria cirrhosa powder and Fritillaria cirrhosa batch dew, and 68 cases were cured, accounting for 63%; 2 1 case, accounting for19.4%; 1 1 case is effective, accounting for10.2%; 8 cases were ineffective, accounting for 7.4%; The total effective rate was 92.6%. 5/kloc-0 cases of children's cough were treated by atomizing inhalation of houttuynia cordata injection and Shedan Chuanbei solution, which has the characteristics of quick response and no side effects. 30 cases were cured, improved 15 cases, and 6 cases were ineffective, with an average of 3 effective times. 2.3 Treatment of throat diseases 36 cases of throat diseases were treated with Dragon Ball buccal tablets (snake gall, pearl powder, mint, etc.). ), 9 cases were cured, 3 cases were markedly effective 10, 4 cases were ineffective, and the total effective rate was 88.9%. 2.4 Treatment of asthenopia 40 cases (74 eyes) were treated with Pearl Snake Gallbladder Mingmu Liquid (composed of nacre powder, snake gall, borneol and honey), and 36 eyes were effective in hyperactivity of liver yang, with an effective rate of 85.7%; 27 eyes of red eye disease with stagnation of heat in liver meridian were effective, and the effective rate was 84.8%. The average effective rate of the two types was 85.65438 0%. 2.5 Treatment of acne 40 cases were treated with snake gall acne cream, 5 cases were cured, 4 cases were markedly effective/kloc-0, 7 cases were effective/kloc-0, and 4 cases were ineffective, with a total effective rate of 89%. 2.6 806 cases of acne were treated with snake gall products. The cure rate was 16 1 case, the marked effect was 156 cases, the improvement rate was 48 1 case, and the total effective rate was 98.9%. 2.7 Enhance immunity Luoxiquan and other self-made snake gall health tea (composed of three kinds of snake gall, Luohan, Kharkov sour plum, etc. ) can enhance human immune function. 357 patients with mild sore throat, dysphagia or foreign body sensation were selected and divided into two groups. The observation group 185 people drank snake gall tea every day for 3 ~ 5 days 1 course of treatment. The control group 172 people drank ordinary bait tea. After 1 course of treatment, all the patients in the treatment group were cured, while none in the control group were cured. 2.8 Other reports show that snake gall can also protect the skin and treat mites and esophageal cancer.