Liver plays an important role in the metabolism of antiepileptic drugs. Most drugs are eliminated by biotransformation in the liver, and the pathological state of the liver can affect the metabolism and curative effect of drugs in the body and cause adverse reactions. Because the drug itself or its metabolites act on the liver, it can cause liver damage and pathological changes. Among the antiepileptic drugs, the common drugs causing liver injury are valproic acid, carbamazepine, phenytoin sodium and non-urethane. There are three types of liver injury caused by antiepileptic drugs: one is hepatocyte type, which is characterized by fatigue, anorexia and nausea, and in severe cases, acute liver necrosis; Second, cholestasis, manifested as jaundice, itching, abdominal pain and so on. , similar to extrahepatic biliary obstruction; The third is mixed type, which has both clinical and biochemical manifestations of the above two types. Liver damage caused by drugs can be comprehensively diagnosed according to medication history, clinical symptoms, hemogram, liver function examination, liver biopsy and the effect after drug withdrawal. The diagnostic basis of drug-induced liver damage is: 1, medication history. Most of the liver damage occurred 1-4 weeks after taking the drug, and some appeared several months later. The initial symptoms may include fever, rash and itching. 3. The number of eosinophils in peripheral blood is 6%. 4. Pathological and clinical symptoms of liver injury. 5. Macrophage or lymphocyte transformation test is positive. 6, viral hepatitis markers monitoring negative. 7. After stopping taking the medicine, the symptoms were relieved and reappeared after taking it by mistake. For the liver damage caused by antiepileptic drugs, the following treatments are mainly carried out: 1, and the drugs causing liver damage are partially reduced or stopped. 2, bed rest, diet therapy, supplement B vitamins and vitamin C. Patients with obvious jaundice can maintain electrolyte balance by intravenous drip of hypertonic glucose and vitamin C. 4. Patients with obvious cholestasis can try prednisone treatment. 5, complicated with explosive liver failure, can be treated as explosive hepatitis. The main measures to prevent liver damage caused by antiepileptic drugs are: 1. During drug treatment, all kinds of adverse reactions should be monitored, and blood picture and liver function should be monitored regularly. 2, ask in detail whether there is any history of drug allergy and allergic constitution, should pay special attention to when using drugs. 3, patients with liver and kidney diseases, newborns, elderly patients, etc ... The choice and dosage of drugs should be carefully considered. 4. If there is any abnormality, reduce or stop the drug in time. 5. Patients with drug-induced liver damage in the past should avoid giving the same or similar drugs again. This article was originally written by Dr. Yang Quanxing. If reproduced, please indicate the source. If there are still patients or their families who have questions about epilepsy, please leave a message on the platform and I will answer them for you. Finally, I wish all epilepsy patients a speedy recovery! Disclaimer: The above content comes from the Internet, and the copyright belongs to the original author. If there is any infringement of your original copyright, please let us know and we will delete the relevant content as soon as possible.