According to the inquiry of Leha Health Care, the plastic box containing ice crystals itself is not toxic, as long as the bottle cap is screwed properly, there will be no problem. Ice crystals and ice crystal boxes are non-toxic and can be used safely.

The chemical properties of ice crystals are very stable, and they are non-toxic and harmless in normal use without damage to the outer container. Can be used for food refrigeration, preservation, refrigerated transportation, barbecue travel food preservation, nursing cold compress and so on.