Wu Youke lived in the last years of Chongzhen and was in a warm epidemic. According to his own practical experience, he compiled the first treatise on febrile diseases in the medical history of China.

Treatise on febrile diseases is a landmark work with epoch-making significance in the history of the development of febrile diseases in traditional Chinese medicine, and it is a prominent embodiment of the original thinking of traditional Chinese medicine theory and new methods of clinical verification.