Alias Chinese Pinyin Yikang Capsule English name Yikang Capsule standard number. WS3-B-2605-97 Prescription Source Drug Standard-Chinese Medicine Prescription Preparation Standard 1997 Dosage Characteristics This product is a capsule, brown powder; It is fragrant, sour and slightly sweet. It has the effects of regulating metabolism, restoring cell vitality, improving cardiovascular function, strengthening brain and body, delaying aging, and strengthening body resistance. It is mainly used for treating coronary heart disease, hyperlipidemia, cerebral arteriosclerosis and senile vision loss. It has adjuvant therapeutic effect on hypothyroidism and chronic senile bronchitis. Usage and dosage: two capsules three times a day; Three months is 1 course of treatment. The preparation methods of the above thirteen herbs are taboo. Except pearl powder, methyl hesperidin, vitamin E and vitamin A, the other nine medicines, such as ginseng, were respectively crushed, extracted with ethanol, and the ethanol was recovered and concentrated into thick paste for later use. Grinding methyl hesperidin into fine powder, adding vitamin E and vitamin A, mixing well, adding mother-of-pearl powder, mixing well, adding appropriate amount of starch, stirring well, drying, pulverizing, encapsulating, and making into 1000 capsule. The inspection shall comply with the relevant regulations under Capsules (Appendix 1l). Identification (1) ultrasonic treatment with petroleum ether (60-90℃) twice, 30ml each time, filtering, and retaining filtrate and residue. Take 5ml of filtrate, put it in a water bath to dry, add 4ml of chloroform to the residue, shake it evenly and dissolve it, and add 0.5 ml of antimony trichloride chloroform solution (1→ 4) to make it blue and gradually turn blue-green. (2) Dissolve [residue with 10ml absolute ethanol, add 2ml nitric acid, shake well, and heat at 75℃ for about15min, and the solution turns orange-red. (3) Take 5ml( 1) of the filtrate under [Identification], dry it in a water bath, add 2ml of ethanol to make potassium hydroxide test solution, boil it for 5min, and let it cool. Drop a few drops of ethanol solution of 2,2-bipyridine (0.5→ 100) and a few drops of ethanol solution of ferric chloride (0.2→ 100), and the edge will be blood red. (4) Take the residue under [Identification]1(1). Evaporating the filtrate in water bath, soaking the residue in ethanol twice, shaking 65,438 00 ml each time, filtering, steaming the filtrate in water bath to about 5ml, adding a small amount of magnesium powder and dropping concentrated hydrochloric acid to obtain red foam and purple solution. (5) Take the remainder (1) under [ID]. Filtering, adding hydrochloric acid to the filtrate to adjust the pH value to 2, extracting with ethyl acetate twice, each time 15ml, filtering, combining ethyl acetate solutions, steaming in water bath to about 2ml, and adding methanol solution of potassium hydroxide (1→ 10), which is orange red. (6) Take [Identification] (65438+) for reflux extraction in water bath for 30min, cool it, filter it, add activated carbon 10g to the filtrate, stir it evenly, dry it in an oven, cool it, add 50ml of ethanol, soak it for 20min, shake it constantly, filter it, evaporate the filtrate in water bath, and dissolve it in 2ml of 0.5% ninhydrin solution. The content should be determined according to the gas. Column temperature is 265℃; According to the peak value of vitamin E, the theoretical plate number should be no less than 500; The resolution between the peak of vitamin E and the peak of internal standard should be greater than 2. Determination of correction factor: Take an appropriate amount of n-dodecane, dissolve it in n-hexane, dilute it into a solution containing 65,438+0.0 mg per 65,438+0 ml, and shake it evenly as an internal standard solution. Take another 20mg of vitamin E reference substance, accurately weigh it, put it in a brown conical flask with a stopper, and accurately add it to the internal standard solution. Inject 1-3μl into the gas chromatograph and calculate to get the product. Determination method: take the contents of this product, weigh it accurately, weigh about 0.24g (equivalent to containing vitamin E20mg), weigh it accurately, put it in a brown conical flask with a stopper, add 10ml internal standard solution accurately, plug it tightly, shake it evenly to make vitamin E, let it stand, take the supernatant 1-3μl, and inject it. This product contains vitamin E(C3 1H52O3) which is 88.0- 1 12.0% of the labeled amount. The specification of the extract is 0.4g/ capsule (containing E33.4mg of vitamin E).