After unremitting efforts, finally three ups and downs, snails climbed into the ovulation stage. According to my own practical experience, I would like to share my experience of ovulation induction with you.
1. There are many drugs and injections to induce ovulation to help patients. I personally injected Gnafen into the abdomen to promote ovulation. I can only share my experience in ovulation induction with you through my own personal experience and feelings. It is estimated that all ovulation induction methods have similar effects on patients' health.
2. Under what circumstances can we start to promote discharge?
According to the network knowledge and personal experience of the hospital, only the down-regulation is successful can we enter the stage of ovulation induction. The sign of successful down-regulation is that multiple follicles of similar size are found.
On this premise, we can smoothly enter the second stage of ovulation induction: that is, by injecting ovulation-promoting needles and taking ovulation-promoting drugs, we will begin to provide a lot of sufficient nutrition for the ovaries, so that every follicle can eat well, grow evenly and thrive!
3. Under what circumstances can the promotion be cancelled?
Some patients will still be cancelled after a few days of injection of Genafen: doctors can judge that the patient's follicles are not growing well by combining the results of B-ultrasound and blood tests, and suggest canceling the cycle and going to the hospital again the next day.
I tried my best to search online, but I still couldn't find any authoritative answer. Here, I can only give you some information that may be useful based on the exchange of experience between patients.
-Some patients say that if the blood test finds high androgen, the cycle will be cancelled;
-Some patients also said that estrogen should be controlled within a certain range (I don't know how much, but it seems to be judged by combining other sex hormone indicators), otherwise the cycle will be cancelled.
3. What is ascites?
In the ovulation induction stage of Genafen, some patients will be stimulated to produce a considerable number of follicles (usually relatively young patients and patients with good ovarian function). On the one hand, it provides more resources for the success of IVF surgery, but on the other hand, it also increases the risk of ascites.
From the symptoms, ascites refers to the accumulation of a large amount of liquid in the abdomen, the patient's abdomen bulges, and some seem to be pregnant for several months and feel abdominal pain. Under normal circumstances, patients can relieve symptoms by eating boiled egg whites and diuretic foods (such as watermelon juice, winter melon soup, and drinking more water). ) and urinate as much as possible. But if this doesn't work, you must go to the hospital for emergency treatment. Severe ascites, also known as "ovarian hyperstimulation syndrome", needs infusion treatment.
I read this passage from the Internet: "In assisted reproductive technology, the level of serum estrogen is >; When 3000 pg/ml (11000 pmol/L) and there are more than 20 follicles with a diameter equal to or greater than 12 mm, the incidence of ovarian hyperstimulation syndrome increases. " Moreover, I also noticed that the serum estrogen level in my hospital is >: 3000 pg/ml, and the doctor will specifically indicate E2 >: 3000. These patients will stop taking genafen. Even so, some patients will continue to increase follicles and the level of estrogen will continue to climb after stimulation by ovulation-promoting drugs. I have seen a patient who has reached E2 > > when taking eggs. The level of 6000. She ate a lot of eggs, and the nurse repeatedly told her to eat more egg whites and diuretic food. If she doesn't urinate at night, she will go to the hospital for emergency treatment. ...
4. Precautions:
* I saw a publicity notice in the corridor of the hospital outpatient department to the effect that Guo Nafen was used to "collect" more follicles in the ovary, so I must pay attention to rest, stop exercising and keep fit.
* Although the nurse told me that I could sleep in the same room during the treatment of Gnafen, I was still afraid of sleeping in the same room when the largest follicle grew to more than14 mm.
* Gonafen must be kept in cold storage. On the way to the hospital, I also put it in an insulation bag with several bottles of frozen mineral water to keep the temperature low. It is said that foreign patients must provide refrigerators or help to refrigerate medicines when looking for hotels.
5. Record of ovulation induction stage (recorded as GNF 1 from the first day of gunafen injection):
GNF 1, that is, the 20th day after intramuscular injection of antihypertensive needle Dafen, the blood results showed that estrogen (E2)=40.22 pg/ml (slightly higher than the reference value of 40), and other indicators met the requirements. Begging the director piteously, I finally agreed to enter ovulation induction, on the condition that I must write a sentence on my medical record, "Understand the condition and ask to enter ovulation induction stage" and sign my name. After that, the doctor prescribed me Gnafen for four days, injecting 300 units into my stomach every day, and I took the first injection that day.
Guona powder is expensive, a box of 450 sticks 1800 yuan. Need to be preserved at low temperature. Fortunately, I made the best preparation that day and took an empty insulation bag to the hospital. After paying the money, I stood in line at the drugstore and asked my husband to go to a nearby supermarket to buy four bottles of frozen mineral water, which were put in an insulated bag with the medicine box to keep the temperature low.
When I got home, I cleaned a drawer in the refrigerator and put the medicine in it. And the medicine box is wrapped in a clean plastic bag in advance to ensure that the medicine will not be polluted by other things in the refrigerator.
Gonafen is best injected at a relatively fixed time every morning.
GNF 2-4
* Yellow secretion, similar to the yellow secretion that sometimes appears before ovulation in the natural cycle.
* Increased stool. Or the sense of convenience is enhanced, and the feeling of wanting to go to the toilet to defecate is increased. Sometimes it is fruitful, sometimes it is not.
* I have been suffering from chronic pharyngitis, and I often feel nausea and retching when brushing my teeth. But since the injection of Gnafen, the symptoms of nausea have worsened, and almost the toothpaste began to retch as soon as it touched my teeth. At first, I thought it had nothing to do with the injection. Later, when I saw that the side effect of Genafen mentioned "nausea and vomiting", I realized that the aggravation of nausea during brushing was caused by Genafen.
Attachment: Adverse Reaction of Genafen
Very common (>110)
Ovarian cyst;
Mild to severe injection site reaction (pain, redness, congestion, swelling and/or discomfort at the injection site);
Headache.
Ordinary (1100-110)
Mild to moderate ovarian hyperstimulation syndrome (see "Precautions");
Abdominal pain and gastrointestinal symptoms, such as nausea, vomiting, diarrhea, abdominal cramps and flatulence.
Rare (11000-1100)
Severe ovarian hyperstimulation syndrome.
Rare (110000-11000)
Complications of ovarian torsion-OHSS.
Extremely rare (
Thromboembolism is usually associated with severe OHSS;
Mild systemic allergic reaction (erythema, rash, facial swelling).
GNF 5 B ultrasound+blood test
Ultrasound examination of follicles: 14.5mm, 10mm, 9 mm+00 mm, 9mm 10mm on the left, 9mm and 9mm on the right. The doctor said to himself, well, there is another one on both sides. -I'm happy, too. Four days ago, there were two left and one right (5mmx2, 4mmx 1). Nowadays, the left three and the right two are all growing.
The doctor told me not to wait for the blood test results, and gave a new plan: continue the injection for two days (plus two injections), and then do B-ultrasound+blood test.
The new scheme is as follows:
Gonafen is injected into the abdomen at a dose of 300 units per day. It didn't hurt after playing, but it hurt a little after playing, but it was tolerable and the pain didn't last long. The nurse gave us a hint that the needle didn't hurt.
Dabeijia is injected with 0.05 unit-abdomen for a long time, which will hurt, but it can be tolerated. The nurse hinted to us that the needle hurt a little.
One pill a day to promote urination-buttock injection, the nurse suggested: this needle is quite painful. Because I was psychologically prepared, I felt fine when I first got into the needle, but in the end I couldn't help moaning because the pain was unbearable. I tried to keep my voice down, but I still scared the patients waiting in line for injections. The nurse said, look, it hurts!
GNF 6, keep injecting.
Gnf 7 b-ultrasound+blood test
* Gonafen is reduced to 225 units per day, and the dosage of dipyridamole and diuretic is unchanged, and it will be played for another two days.
* Today, some patients said that drinking more water is also beneficial to follicular growth. I wonder if there is any scientific basis. But there's no harm in drinking more water. I see.
* Another patient said that the pants worn during the promotion period must be loose. She deliberately wore a pair of sweatpants with elastic bands instead of jeans, so the nurse insisted on wearing them more loosely. On second thought, I'd better buy a pair of maternity pants. Anyway, it will be used soon, starting with ovulation induction.
* There is also a hint for everyone: Be sure to think about your husband's sperm discharge. Don't wait for the doctor to tell you. They are so busy that sometimes they forget to tell you.
There is a sign in the corridor of the reproductive center to remind everyone that the husband should ejaculate once 3-5 days before the egg retrieval operation to ensure that the semen is fresh and high quality on the day of egg retrieval. I read from the Internet that when the largest follicle grows to 14mm- 15mm, it needs to ovulate. I had a B-ultrasound today, and I specifically asked the doctor: How big are the follicles that need my husband to ejaculate? On the one hand, I want to verify whether the online statement is correct, on the other hand, I am also reminding doctors. The doctor didn't answer immediately. I thought she didn't hear it. After a while, two words popped up in the doctor's mouth: tomorrow. I don't know if the doctor is talking to me or someone else.
Later, I saw that my largest follicle was 14.5mm on the record. After thinking about the network knowledge and the doctor's words, I decided to ovulate tomorrow. It turns out that tomorrow's sperm discharge seems a little late. If today's sperm discharge happens to be three days after the day of taking eggs, that is, the day when the hospital collects her husband's semen.
GNF 8, keep injecting.
Leucorrhea appeared last night, and this morning there was a lot of leucorrhea, like a big nose. So I remembered yesterday in the consulting room, a patient asked the doctor: I have a lot of leucorrhea and obvious drawing. I won't ovulate myself before taking the eggs, will I? The doctor replied: No, we are anti-drug. I'll let you know when it's time to get the eggs.
D9 B-ultrasound+blood test
* After the blood test results came out, the doctor told me that there were three qualified follicles, all in the right ovary, ready to take eggs.
* After the doctor decided to take the eggs, 7788 issued a lot of bills, and it was 17000 yuan at one time, including injection, washing, egg removal surgery, transplantation surgery and single sperm injection.
I won't know until I ask the doctor. Under normal circumstances, after taking the egg, the egg and sperm will be put together in a Petri dish, and the sperm will run into the egg by itself, and the fertilized egg will be successfully combined. Single sperm injection is to take out the active molecules from semen by technical means and inject them directly into the egg to complete the combination of fertilized eggs. The success rate of the latter is obviously higher than that of the former. The reason is that some people's sperm don't like to play with eggs and swim around her but refuse to go in. Of course, most people's sperm still like their wives' eggs.
Under what circumstances should sperm injection be performed?
-Husband's semen quality is not high, and there are not many high-quality sperm. Just in case, directly use sperm injection to improve the pregnancy rate.
-Wife has too few eggs. In order to produce more fertilized eggs, single sperm injection was used.
I only have three qualified follicles, and my husband's semen is actually not very bad, so it is estimated to be the second reason.
A single sperm injection costs 4000 yuan more. But it can improve the mating rate of zygotes. So I spent the money happily.
* Starting today, I will go to the hospital to wash the surgical site every day for three consecutive days. Because it's getting late and it's almost noon, the nurse asked me to wash it before paying. Anyway, at this point, no patient will run away after washing.
* Because the egg retrieval operation is semi-anesthetized, it is necessary to use Demerol, which is a restricted drug and must be stamped by the hospital. The hospital office should check the patient's ID card, so remind everyone to bring their ID card when going to the hospital!
* Before I left the hospital at noon, I ate another half of Dapitica.
* Go to the emergency room to inject "HCG" at night according to the time prescribed by the doctor. The injection time of this needle is very important, and there can be no difference of ten minutes in the morning and evening. So are the nurses in the emergency room. You hung up the emergency number in advance, asked the gynecologist in the emergency room to make a list, paid the fee, went to the injection room and told the nurses when to have an injection, which impressed them. Time is running out, then go back to the injection room. No matter how many people are waiting in line, as long as you remind the nurse when you need an injection, she will give you an injection on time.
D 10 blood test+washing. But don't wait for the blood test results.
D 1 1 date of egg retrieval
The process of this day is like this:
1. Patients and husbands should go to the hospital very early, because the first person accepted by the reproductive center is the egg retrieval patient.
2. The husband and wife go in together first, get the marriage certificate and ID card, and the nurse will check the original. The main purpose is to check the photos on the certificate with the husband himself to avoid the fake husband who is an impostor. -I heard that such a thing happened in the reproductive center. Children are born, that is, two or three years old. As a result, the real husband came, and it was verified that it was not the husband himself who signed at that time. The hospital caused a lot of trouble. Listening to a patient, once the doctor talked to her about it, she burst into tears. The doctor meant to help you have a baby, but he was cheated by the patient ... the doctor felt bad!
My husband went to a room to get semen and wrote his wife's name on the test tube. Wives go to draw blood.
4. When the husband goes out to the clinic, the wives take turns to do B-ultrasound.
5. The doctor gives the patient a B-ultrasound+blood test sheet on the day of transplantation. Some people will prescribe more needles and medicines.
6. According to the pre-arranged operation sequence (arranged on the day when D9 decided to take eggs, the time of HCG injection was also arranged in this order, and the injection time between two people was 15 minutes), they went into the washing room for washing, and then went directly into the operating room to take eggs.
7. Most patients who take less eggs come out by themselves, climb onto the movable bed parked outside the operating room, and then be pushed to the lounge by the nursing staff. The patient who took more eggs pushed the moving bed into the operating room and took her out.
8. According to the results of blood drawing and B-ultrasound, some patients who take eggs need injections before leaving the hospital, while others don't. You must know for yourself. In addition, progesterone should be injected every morning and afternoon from the day of egg retrieval to the day of transplantation. If you want to take it home and make it yourself, first ask the nurse to draw a circle on your ass, and then you must give an injection in this circle.
* Briefly talk about the operation.
Although I was anesthetized, my mind was still clear because I was semi-numb. I have very few eggs, and the whole operation only takes more than ten minutes. In this process, nurses and doctors will ask me my name from time to time, or call me for an answer. I think they are making sure that I am awake and have an anesthetic overreaction.
Since I used anesthetic, I think it must be painless, but I still have a tactile reaction to know that the doctor is operating. But in a flash, I suddenly cried out in pain. The doctor said: Don't scream. The more relaxed you are, the more comfortable you will feel. The more nervous, the worse. I gradually relaxed and really felt much better. But soon after I completely relaxed, I suddenly cried out in pain. The doctor said: hold on, it's almost ready.
I even began to be glad that I had few eggs, and the operation was over soon. The doctor said: very good. There are all three. -What do you mean? Later, I realized that some people have large follicles, but they are empty and there are no eggs in them. The doctor said that although I only have three follicles, they all have eggs. It's good.
The operation is over. The nurse asked me to sit up first and feel dizzy. Not bad. The nurse asked me to go downstairs and open the door by myself. Probably think I'm not walking steadily. Help me send me to the mobile bed outside the door. I don't know where the nurse went, and there is no one outside the door. The nurse asked me to sit on the bed and lie down, then pushed the bed a little farther away from the operating room and said, you lie down, and someone will push you into the lounge later. That's when my "hallucinations" began to appear. When I close my eyes, I always feel that the bed is slipping backwards and the surrounding walls and cabinets are moving forward. I can open my eyes and see that everything around me is still, and the bed, walls and cabinets have not moved. Later, the nurse pushed me into the lounge, leaning against a wall, and this feeling continued. There is a thick pipe in the corner, and there is water in it. For a time, I felt like I was on the boat, rocking from side to side on the water ... Several patients had finished taking eggs and were resting. They chatted and exchanged their feelings about the operation. But I don't want to talk at all. Even if I interrupt occasionally, my voice is very weak. I feel dizzy. The effect of anesthetic is showing.
Later, I found that patients around me would moan in a low voice as long as they didn't chat. She ate a lot of eggs and her stomach hurt badly. She needs to take the initiative to chat with others to divert her attention. My stomach doesn't hurt very much, but it feels similar to that after angiography, that is, it feels like a slight dysmenorrhea. But I was dizzy and vaguely felt that I was far away from others, as if wandering in another world. Somehow, tears came down. The patient next to him asked, "Are you crying?" "hmm." "Does it hurt?" "No pain, just dizziness." "The strength of narcotic drugs haven't you in the past. I hope I have a reaction to the anesthetic, so at least it won't hurt. ..... well, think about the worst stage. We all survived, and it will be much better in the future. ..... don't sleep for a while, just fall asleep. "
Other patients asked their families to bring breakfast in after the operation. Because the nurse told us before the operation: blood drawing, B-ultrasound and operation should be on an empty stomach. Be sure to ask your husband to buy breakfast and send it to the nurse to replenish his strength after the operation. My husband may want to see what other people want to eat. I didn't move. I entrusted a patient to come in and ask. I don't know who it is, but I heard a voice say: Your husband asked if you want to eat? My weak answer: I am dizzy. Don't want to eat. The patient said, then don't eat.
I don't know how long it took, but I felt that the world around me began to calm down. It seems that I have finally returned to the hospital lounge from that constantly shaking world. I began to feel thirsty. My patient lent me his mobile phone and called my husband to get some water. Struggling out of bed, leaning against the wall, barely took a few sips of water. The patient sleeping next to me kindly reminded me to drink less water when dizzy, so as not to want to go to the toilet in the future. So he lay down with a glass of water in his arms.
I don't know how long it took, but I heard the nurse's voice: one of you must leave. The next patient's operation will be finished soon, and there is no movable bed. I'm number 5, the number 3 who took a lot of eggs next to me, and the number 6 who came out last next to me. There is a fixed wooden bed with the door open and number four lying down. 1 and 2 have left. No.3 said I was up, and she just sat up and kept shouting dizzy, dizzy! Let me think about it. No.6 just came out, and the anesthetic seemed to have passed, so I said, I'd better get up, and I won't faint. You have taken so many eggs, it's embarrassing to let you go now. That girl is really nice. She said that if you lie down for a while, I won't faint if I sit for a while. However, she doesn't seem to recover soon. At this time, No.4 lying on the wooden bed said, otherwise, which one of you will come down and squeeze a bed with me? Look at number three. I said you lie down and I'll go down and squeeze with her. No.3 told me as soon as he lay down: slow down, sit still, and then get down on the ground.
When the nurse came in again, I was already lying on the wooden bed, making room for her to push out. She looked at us and said, hey, you two sleep in the same bed. -But there's absolutely no blame.
After a while, I suddenly heard No.6 begin to shout dizzy, dizzy! Her anesthetic began to take effect. ......
I always lie in the lounge for two hours. No.4, I think it's okay. I'll go first. I lay alone on the wooden bed for more than half an hour. The nurse came in to urge: the last patient who came in can have a rest and the other patients can get up. In this way, the three of us with eggs began to get dressed and get up. Three transplant patients who came in later agreed to lie down to 12 and get up together.
* From the day of egg retrieval, progesterone should be injected twice every morning and afternoon. The progesterone on the morning of egg retrieval was already on the operating table. I will take it home to play in the afternoon. So I asked the nurse to draw a circle on the left and right buttocks and took five disposable syringes. The nurse told me that the left and right sides should take turns to fight, so that the medicine can be better absorbed.
* HCG(2000 units) was also injected after the operation that day. It was found that some patients who took eggs took this injection, while others did not. Some patients say that this medicine is used to adjust the endometrium. People with appropriate intimal thickness do not need to adjust. -I wonder if that's right?
* Note: If it is summer, it is best to wear underwear that is separated from top to bottom, and don't wear skirts, especially dresses. I specifically asked the nurse about this. The nurse said that wearing skirts is more likely to cause bacterial infection.
D 12-D 13 inject 2 tablets of progesterone every morning and evening, and give it to mother at home. According to the nurse's instructions, the injection time is 8:00-9:00 am and 3:00-4:00 pm. I still think it's better to have an injection at home. Progesterone is oily. At home, my mother pushed the needle slowly, and it didn't hurt at all. In the hospital, there were so many patients that the nurse quickly gave an injection to replace the next patient, and everyone shouted pain!
My IVF ovulation induction stage went very smoothly. If I change the difficulty of the downward adjustment stage, it is very important to lay a good foundation in the early stage.
Medical expenses in ovulation induction stage: medical expenses in ovulation induction stage (I ovulate for 8 days, which is relatively short, and if the ovulation induction time is long, the cost will probably be more than RMB 1000 per day), including 4 B-ultrasound, 5 blood tests, 5 boxes of Gnaphane (450 units in a box), 2.5 tablets of Dabijia and 4 tablets of Urogenol,/kloc-0. Plus registration fee, injection fee, cleaning fee, egg retrieval operation fee, single sperm injection fee, and so on. In addition, the transplant operation fee was also paid before taking the eggs. * * * It's about 28,000 yuan.
Happy, ready for transplantation!