Hyaluronic acid and botulinum toxin are two different injection cosmetic materials, and it is very common to achieve the effect of plastic wrinkle removal by playing hyaluronic acid or botulinum toxin. But after many years of injection, there will be some adverse reactions, even life-threatening. Hyaluronic acid is hyaluronic acid found in the ingredient list of skin care products in daily life, and it is one of the components of human dermal tissue. Hyaluronic acid injection is to inject hyaluronic acid as a filler into the body parts with wrinkles or depressions in the dermis, such as lips, cheeks, nose bridge, chin, etc., which can achieve immediate results. However, hyaluronic acid will soon be absorbed by the human body, so in order to have a lasting effect, intermittent injection is needed. Once the injection is continued irregularly, the effect will gradually fade away and finally disappear completely. Hyaluronic acid has fewer side effects, so the chances of causing allergic reactions are also reduced a lot, and it is also easily decomposed by the human body, which has no long-term side effects on the human body. However, things are not absolute. If hyaluronic acid is injected for a long time, local redness, pigmentation, infection, etc. May occur on the skin. If the injected person is in poor health, the risk will be greater. Botulinum toxin is a neurotoxic exotoxin produced by Gram-positive anaerobic botulinum during its reproduction. It can inhibit the release of acetylcholine from the presynaptic membrane of peripheral nerve endings and block the transmission of neurotransmitters, thus causing muscle relaxation and paralysis and reducing muscle tension. The muscle spasm was relieved and the expected effect was achieved. Compared with hyaluronic acid, botulinum toxin can keep its plastic effect better and last longer, both of which may lead to allergic phenomena or local swelling, pain and toxic reactions. Generally, these symptoms may appear at the time of use, or in a few months or a year or two, and each person appears at a different time. When this bad phenomenon occurs, it is necessary to stop the injection and then treat the symptoms.