1976 started guest TV series. 1978, she entered the film industry with the horror film "Moonlight Panic" and won the Best Actress Award at the Paris Science Fiction Film Festival. Later, she became famous for a series of horror movies. 1983 was well received for its successful transformation with the comedy "Reversing Gan Kun".
Later, she became the focus of people's attention again with two films, A Fish named Wanda and Baby Lover. She convinced fans and film critics that she was not only famous for her parents' fame. 1994, she starred in True Lies, and her outstanding performance in this film won her a Golden Globe Award.
1998 starred in the sequel "The Holocaust" of "Moonlight Panic" and made an excellent return. In 2003, Jamie Lee Curtis changed her old style and appeared in the comedies Hot Mom and Spice Girl. Her wonderful performance has been unanimously recognized by film critics and won the Golden Globe Award for Best Actress in Music, Film and Comedy.