20% of infections are persistent, and 9% of them have cervical cancer within two years.
What exactly is human papillomavirus?
Human Papillomavirus (abbreviated as Human Papillomavirus) is a kind of Papillomavirus A, which belongs to the family Mammaloviridae. It is a spherical DNA virus, which can cause squamous epithelial hyperplasia of human skin and mucosa. Up to now, more than 30 species of/kloc-0 have been isolated, and different types cause different clinical manifestations. The process of cervical lesions caused by persistent infection takes about 8- 12 years.
Because human papillomavirus widely exists in nature, human skin, digestive tract, respiratory tract and so on all carry this virus. Therefore, it is possible for all women who have sex to bring human papillomavirus into the reproductive tract through sexual contact.
Because when the human body is infected with this virus, a few patients will soon become immune to the virus. When the immunity is strong enough, human papillomavirus will be eliminated. Therefore, a large number of medical statistics show that although the proportion of human papillomavirus infection is very large, most of them are transient, that is, the virus will naturally disappear within 1 -2 years (generally referring to human papillomavirus infection). Most women's immune system can eliminate the human papillomavirus entering the body, and only a few women with weak immune function can't eliminate the human papillomavirus entering the body, which leads to the persistent infection of human papillomavirus. The process of cervical lesions caused by persistent infection takes about 8- 12 years.
Communication channels, close contact and communication.
indirect contact
Iatrogenic infection
The common symptoms of human papillomavirus infection are: condyloma acuminatum, verruca plana and other viral warts, gynecological "cervical erosion" (cervicitis), cervical precancerous lesions, and even cervical cancer.
How to effectively remove PHV?
1. At present, there are no effective drugs for high-risk human papillomavirus infection, and therapeutic vaccines have not yet come out; 2. Transient infection does not need treatment, but it is difficult to distinguish primary infection from recurrent infection in clinic. There is no obvious boundary between active infection and latent infection, and different types of viruses have different virus power; 3. High-risk human papillomavirus (HPV) infected people often have the problem of insufficient immune function, and the probability of young women's immune function automatically eliminating HPV may not be100%; 4. Conservative treatment methods, such as logistic therapy and conization, can not eliminate local human papillomavirus infection, and there are limited methods to eliminate local human papillomavirus infection in postoperative follow-up. The recurrence of CIN is related to the positive of human papillomavirus. 5. Interferon treatment of local immune regulation (such as Baofukang suppository) will not damage the organ function of patients.
Treatment of High-risk Human Papillomavirus So far, there is no big data in the world to explain which drug is more effective. As far as western medicine is concerned, interferon, an immune enhancer, is theoretically useful. Because the disease is mainly local, local interferon is often used for treatment.
On 20 12-20 15, the National Tour Exhibition of the Expert Seminar on the Integration of Diagnosis and Treatment of Reproductive Tract Infection of Chinese Medical Doctor Association recommended that the intervention time of domestic reproductive tract gynecological infection group on human papillomavirus infection should be 90 days.
At the same time, the therapeutic goal of human papillomavirus infection is also clearly put forward:
1. Breaking the current situation of human papillomavirus infection
2. Remove human papillomavirus virus.
The 3-month complete intervention cycle plan is as follows:
popular science knowledge
1、
(Replication cycle of human papillomavirus: 56 days) The process of increasing the value of human papillomavirus is called replication cycle. It can be roughly divided into five stages: adsorption, invasion, proliferation, maturation (assembly) and lysis (release), and it takes about 56 days to complete a virus replication cycle.
2、
(Skin epidermis replacement cycle: 28 days) The outermost layer of epidermis is stratum corneum, which is an important guarantee for the skin to play its protective function, and this layer of cells will fall off continuously. At the same time, the most basic layer will continue to divide and proliferate, move to the stratum corneum, and replenish exfoliated cells. This process usually takes 28 days.
3、
The target cells attacked and infected by human papillomavirus are mainly mucosal epithelial cells with high proliferation ability, that is, basal cells. Only when the physical barrier of epidermis is destroyed can human papillomavirus enter basal cells. However, in women's body structure, cells with similar structures are very susceptible to human papillomavirus infection at the junction of cervical squamous epithelium and columnar paving (that is, the junction of scales and columnar paving).
During the 56 days of continuous action of interferon, the "stagnant" human papillomavirus continued to move to the outermost layer of epidermis with the differentiation of basal layer, and finally fell off.
L When the last part of human papillomavirus is suppressed (interferon has been acting for 56 days), its clearance time is 28 days when the basal layer moves outward and falls off.
According to statistics, the infection rate of human papillomavirus in the general population is very high. Among young women, the infection rate of human papillomavirus can be as high as 20%. Most studies also found that the peak age of human papillomavirus infection was between 18 and 30 years old, and after 30 years old, the infection rate of human papillomavirus decreased significantly, about 4% to 6%. Now the incidence of cervical cancer also presents two peak ages, one is 35 to 45 years old, and the other is after 50 years old. Compared with 20 years ago, there has been an obvious trend of youthfulness. However, experts say that even if infected with human papillomavirus, most women will not suffer from cervical cancer, because every healthy woman has certain immunity. Studies have confirmed that after being infected with human papillomavirus, most women's immune system can remove human papillomavirus from their bodies. Only a few women will continue to be infected with human papillomavirus because they can't rule out the human papillomavirus entering the body, thus causing cervical precancerous lesions. Some of these patients will further develop into cervical cancer, which will take about 5 to 10 years.
Finally, I attach some typical questions that my friends have asked for the longest time for your understanding ~
Q&; A
Does human papillomavirus infection only occur in unprotected women?
Human papillomavirus infection is contact transmission, but it is not unique. According to statistics, about 70% women of childbearing age will be infected with human papillomavirus in their lifetime. Therefore, we advocate a protective roommate.
Human papillomavirus infection is definitely a sexually transmitted disease. Do you need to examine your husband?
The transmission route of human papillomavirus infection is mainly sexual transmission, but there are other ways; The detection of human papillomavirus is of little significance for men to find cervical cancer and high cervical lesions.
Is it forbidden to have sex with human papillomavirus infection? Is it necessary to have contraception in the same room?
There is no evidence that sexual intercourse helps to reverse the human papillomavirus. Condoms can't completely stop the spread of human papillomavirus infection, but they can reduce the ability to spread.
If HPV is positive, is it necessary to terminate the pregnancy?
No need.