At present, only four or five big cities such as Beijing, Tianjin and Shanghai have listed Jiefukang in the medical insurance catalogue, while Sichuan, Guangdong, Shandong and Yunnan have not. In other areas except Beijing and Shanghai, you can buy Jiefukang at your own expense in the hospital, but you may not be able to use medical insurance to reimburse and reduce medical expenses. As for when Jiefukang can be included in the scope of medical insurance reimbursement in Sichuan and other places, we don't know at present, it must be soon. By then, patients in Sichuan, Guangdong, Shandong and Yunnan can use medical insurance to purchase and reimburse expenses in Sichuan, Guangdong, Shandong and Yunnan.

Of course, when we released this information, we did not check with the local medical insurance department in Sichuan. If patients think it is necessary, they can call or go to the medical insurance center or the related infectious disease hospital for consultation and verification.

Known regions that support medical insurance reimbursement and purchase Jiefukang: Beijing, Tianjin, Shanghai and Hebei Province.

First, the medication method of Jiefukang

1, once a day, one tablet at a time. Swallow the whole tablet. Do not chew or break it.

2. Take it with foods with high absorption rate (a small amount of solid or liquid food is enough) at the same time, or take it within 0/5-30 minutes after meals; After eating, due to the existence of food, the gastric emptying time is prolonged, food and medicine can be more fully mixed and ground, and the contact area between the mixture and gastrointestinal tract is significantly increased, which is beneficial to absorption. At the same time, the fat and protein in food can also assist the dissolution and/or absorption of these two drugs, further increasing the absorption of drugs.

3. Avermectin is easily complexed with multivalent metal cations to form insoluble substances, which will affect the absorption and lead to the decrease of drug concentration in blood, thus inducing drug resistance. Therefore, Jiefukang should be isolated from vitamins, mineral supplements or mineral-containing multivitamin supplements for at least 4 hours. Antacid (such as calcium carbonate, magnesium oxide, aluminum hydroxide, magnesium trisilicate, etc. ) can also be taken 2 hours before taking Jiefukang;

4. Don't take it with fruits, especially grapefruit and grapefruit, which may lead to the loss of efficacy and drug resistance;

5. Don't take it with other drugs, such as antihypertensive drugs and hypoglycemic drugs.

Second, the use of Jiefukang taboo and matters needing attention

1, not suitable for those who are resistant to integrase inhibitors, emtricitabine or tenofovir;

2, patients with severe liver injury with caution. It has been reported that HIV is complicated with hepatitis B infection, and hepatitis may get worse after stopping using the drug.

Jiefukang is also used for patients with renal insufficiency. Clinical studies show that adults or adolescents (at least 12 years old and weighing at least 35kg) with estimated creatinine clearance (CrCl)≥30ml/min do not need to adjust the dose. Creatinine clearance rate (CrCl) 4. Profovir and combistat in Jiefukang have effects on blood lipids, usually manifested as hypertriglyceridemia, which increases the risk of cerebrovascular disease and coronary heart disease, and may lead to acute pancreatitis in extreme cases. Therefore, blood lipids should be monitored regularly during medication, if the total cholesterol is >: 200 mg/dL or >; 5.2 mmol/L; Low density lipoprotein >130mg/dl or >; 3.4 mmol/L; Triglyceride >; 150mg/dl or more; 1.7 mmol/l; Or two or more of them are higher than the normal range, please be sure to consult the attending doctor and use drugs to reduce blood lipid, such as fenofibrate (simvastatin is prohibited). At the same time, Jiefukang may get fat, so it is necessary to adjust the diet structure and appropriately increase aerobic exercise (such as brisk walking, jogging, swimming, cycling, playing Tai Ji Chuan, doing fitness dance, skipping rope, rhythmic exercises, etc.). ).