Supplement:
How much Q 10 is really absorbed by the human body?
Pharmacokinetic studies show that the oral absorption of exogenous CoQ 10 is mainly emulsified by pancreas and bile in the small intestine, then dissolved into chymotrypsin with low specific gravity, and then entered the blood circulation through lymph. Q 10 first becomes a part of mesenteric triacylglycerol-lipoprotein after absorption, and then is converted into chylomicrons by lipoproteinase, and then enters the liver, and reassembles into very low-density lipoprotein or low-density lipoprotein (VLDL/LDL) particles to enter the circulation, which is similar to the absorption of α-tocopherol. High density lipoprotein also contains a small amount of CoQ 10.
After oral administration of Q 10, there will be an absorption peak within 5- 10 hours and a regeneration peak around 24 hours due to liver reorganization.
Animal experiments and human experiments show that oral administration of exogenous Q 10 can increase the plasma concentration, and the degree of improvement is related to whether Q 10 is solubilized, dosage, duration of administration and whether vitamin E is taken at the same time.
Effect of continuous administration time and dose on blood drug concentration-the longer the administration time, the greater the dose and the higher the blood drug concentration.
Taking it once has little contribution to increasing the serum concentration of Q 10.
Short-term administration (within one week) and high dose (starting from 100mg/d) can increase the plasma concentration of Q 10, and long-term administration (starting from two months) of 60mg/d can also increase the plasma concentration of Q 10.
The daily dose of Q 10 has been increased to 300mg abroad, and no side effects have been found in long-term monitoring.
China's sFDA stipulates that the daily intake of Q 10 should not exceed 50mg.
Q 10 is a research topic of my graduate students, and I hope it will help you.
refer to
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