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Pharmacological and Toxicological Study on Compound Congrong Yizhi Capsule
In the rat model of ischemic brain injury caused by ischemia-reperfusion combined with hypotension of external jugular vein, this product can reduce the number of mistakes in rat platform test; Shorten the whole swimming time in the water maze test and reduce the number of mistakes entering the blind end; And can improve the pathological changes caused by the model group. In the model of learning and memory impairment in rats after cerebral vascular removal, this product can reduce the number of errors of platform jumping method; The number of times the water maze enters the blind end is reduced, and the swimming time is shortened, which shows that this product can improve the learning and memory test index to some extent. It can also improve the symptoms of cerebral ischemia caused by cerebral thrombosis (reducing the degree of cerebral edema in ischemic rats and narrowing the scope of cerebral infarction) and increase the blood flow of brain tissue in model rats; Increase the deformability of red blood cells, reduce the aggregation of red blood cells and reduce the viscosity of whole blood and plasma; It can inhibit platelet aggregation induced by AA and collagen to varying degrees, but has no effect on prothrombin time, partial thromboplastin time and thrombin time. This product can reduce the wet weight and dry weight of thrombus in rat bypass thrombosis test; It can increase learning and memory, reduce the number of degenerated neurons, improve energy load, reduce the concentration of free calcium ion in synapse, reduce MDA level, increase SOD activity, reduce LA content and increase LDH activity.