A large number of studies at home and abroad show that regular exercise can make beneficial changes in blood lipid and lipase: high-density lipoprotein (HDL) increases, low-density lipoprotein (LDL) and total cholesterol (TG) decrease, lipoprotein lipase (LPL) activity increases, and total cholesterol clearance rate increases. Regular exercise can also change the distribution of HDL and LDL subtypes: HDL2 subtype increases, while SLDL subtype with strong atherosclerosis decreases. Moreover, there is a linear dose-response relationship between the increase of exercise intensity and running distance and the increase of blood HDL-C. These changes can be observed in most men, women and middle-aged and elderly people. Therefore, exercise is a simple and low-cost method, which can not only prevent dyslipidemia, but also prevent hypertension and osteoporosis, and is an effective way to reduce hyperlipidemia.