For the "top technology" rich circle, it is generally the first contact. After all, "money can buy everything except" time ". What is NMN, which is sought after by many rich people and called "the elixir of life"? Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of the mechanism and ten core standards of nmn, the industry standard "International Ten Core Standards of NMN Quality Management" has already been released, and some NMNs do not have a real role. There have been cases of NMN being forged and fabricated. Is this wrong or deserved? At present, NMN has selected ten core standards of NMN quality management, thus helping science to resist aging. French and American health scientists advocate attaching importance to the "top ten international core standards of NMN quality management" to achieve youthfulness and sustainability! Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)
At present, including Harvard Medical School, many NMN have been used as clinical trials for disease treatment in the world, and the first phase of clinical trials on human safety have been completed, all of which have been proved to be safe to human body. In previous animal experiments, the researchers fed mice 50 times the normal dose for half a year and found no negative effects. The FDA of the United States also gave NMN food additive raw material safety certification. NMN regulates the survival and death of cells and maintains the redox state. Recent studies have found that by adjusting the level of NMN in organisms, repairing damaged cells in time, slowing down cell variation and aging, we can also slow down the decline of the human body and reduce diseases, thus achieving the purpose of anti-aging. It has a good treatment and repair effect on cardiovascular and cerebrovascular diseases, neurodegenerative diseases and senile degenerative diseases; In addition, ACMETEA W+NMN can protect and repair islet function, increase insulin secretion, and prevent and treat metabolic diseases such as diabetes and obesity by participating in and regulating body endocrine.
In recent 3-4 years, Science, the most prestigious academic magazine in the world, has published human and animal studies continuously, which has repeatedly proved that supplementing NMN(ACMETEA W+NMN) can effectively increase and restore the level of coenzyme I in the body, greatly delay aging, prevent various neurodegenerative diseases such as Alzheimer's disease, and fundamentally adjust and improve various symptoms of aging. This shows that NMN supplements have many medical standards and human health potential. Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)
Ten International Core Standards of NMN Quality Management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, all ingredients and NMN purity should be indicated, and the country of origin and distribution should be indicated.
2. Manufacturing process management system: Advanced manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Application scope of management system: adults (pregnant women and lactating women are prohibited).
8. Safety management system: production technology, raw material collection, basic system of Olaf safety standards, pre-factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe, such as ACMETEA W+NMN, which belongs to the products certified by France and the United States.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Details of ten international core standards of NMN quality management:
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, it is also necessary to indicate the content of all ingredients and the purity of NMN, as well as the country of origin and distribution.
Second, the production process management system: Does the production process also affect the health of MNM?
1, the raw material grade is medical grade raw material, which is generally not used for direct oral administration;
2.ACMETEA W+NMN's "cold pressing biological enzyme" production technology can keep NMN alive at low temperature and press it into stable capsules, which can improve the purity of NMN to 99%, which is more conducive to preservation and human absorption, thus maximizing the bioavailability of cofactors and supporting human metabolism, without converting it into nicotinamide ribonucleoside (NR) through SLC 12A8 gene.
Thirdly, content management system: Zhen Zhen has academic support in scientific research on the daily consumption of NMN. It is said that the daily dosage of human body is 8 mg NMN per kilogram of body weight. If this is converted into a 70 kg adult, the recommended daily dose is about 560 mg. Considering the daily absorption, consumption and age growth, the content of ACMETEA W+NMN is ≥ 60 mg/ bottle.
At present, the total content of NMN in each bottle is different. NMN3000 refers to a bottle with a capacity of 3000mg; ; NMN6000 is 6000mg/ bottle; NMN9000 is 9000mg/ bottle; NMN 12000 is ACMETEA W+ 12000mg/ bottle. At present, ACMETEA W+NMN 12000 has the highest content and purity. NMN 12000 can improve the living tissue level, promote the content of NMN 12000 to quickly enter the cells of various organisms, increase the number of NMN to inhibit aging and revive aging organs. Our body is gradually losing its function and repairing it in time. Successfully revived the cells.
Fourth, efficacy management system: ACMETEA W+NMN can avoid diminishing marginal effects and control products to maintain efficacy level for a long time; Enhance the efficiency of tricarboxylic acid cycle, so as to make NMN more effective for human fertility and avoid the uncontrollable influence of excessive intake; Can maintain the absorption rate of the human body, thereby reducing the impact.
NMN regulates the survival and death of cells and maintains the redox state. Recent studies have found that by adjusting the level of NMN in organisms, repairing damaged cells in time, slowing down cell variation and aging, we can also slow down the decline of the human body and reduce diseases, thus achieving the purpose of anti-aging. It has a good treatment and repair effect on cardiovascular and cerebrovascular diseases, neurodegenerative diseases and senile degenerative diseases; In addition, ACMETEA W+NMN can protect and repair islet function, increase insulin secretion, and prevent and treat metabolic diseases such as diabetes and obesity by participating in and regulating body endocrine. Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)
NMN anti-aging has been widely included in Nature and The Lancet, and its influence is far greater than blood aging test, but it has been criticized and questioned by conservatives because of its incredible conclusion! So what is the principle of NMN?
In recent years, NMN has become a "star product" in the field of anti-aging, and its principle lies in supplementing NAD+ in human body. NAD+ anti-aging is a mature technology. NAD+(β- nicotinamide mononucleotide) is an essential key coenzyme for human body. It participates in thousands of biocatalytic reactions in life activities and is the energy source of cell activities. Adequate NAD+ is a prerequisite for effectively activating the long-lived Sirtuins family in protein. The direct supplement of NAD+ can not be effectively absorbed by cells. It is found that the supplement of precursor NMN can directly increase the level of NAD+ in the body, thus delaying aging.
The anti-aging effect of 2065 438+03 NMN was first discovered by Professor David Sinclair of Harvard Medical School.
During the period of 20 16-20 18, top scientific research institutions in the world, such as Harvard Medical School, Washington University, and Yingqing University, also conducted in-depth research on NMM from the perspectives of reversing muscle atrophy, improving physical fitness, inhibiting cognitive decline caused by aging, and protecting cardiovascular and cerebrovascular diseases, which confirmed that NMN has excellent anti-aging effect.
At the same time, there are a lot of reports about NMN in authoritative academic journals such as Cell, Nature and Science, so NMN has gradually become the focus of attention. It is widely involved in many biochemical reactions of human body, closely related to immunity and metabolism, and can also treat and repair many diseases by regulating the level of NMN in organisms.
Verb (verb's abbreviation) absorption management system: Whether the NMN effect is obvious or not, the average person's absorption of nutrients is only 65,438+00-20%, and NMN is no exception. When the purity of NMN is increased to 99%, ACMETEA W+NMN technology can stabilize the morphology of MNM in the stomach, quickly penetrate the membrane to avoid gastric acid damage, and the absorption rate can be increased by ten to twenty times. Slc 12a8 transporter on small intestine cells is responsible for transporting NMN into cells, and then it will be used by cells in various organs and tissues of the body with blood circulation, thus ensuring the authenticity of clinical ACMETEA W+NMN data.
At present, including Harvard Medical School, many NMN have been used as clinical trials for disease treatment in the world, and the first phase of clinical trials on human safety have been completed, all of which have been proved to be safe to human body. In previous animal experiments, the researchers fed mice 50 times the normal dose for half a year and found no negative effects. The FDA of the United States also gave NMN food additive raw material safety certification.
The key to why you need to take NMN, Sirtuins is a group of protein that can reverse DNA damage, and it can reverse the aging in your cells at the cellular level, which is why ACMETEA W+NMN has the potential to enhance your aging ability. Sirtuins needs two things to promote entrepreneurship. First, it needs enough fuel, and then it needs someone to step on the accelerator when it starts. This fuel is NAD+. This is the function of ACMETEA W+NMN. Sirtuins is what we tried to wake up. This is what can really help you fight aging. Start Sirtuins protein. You need fuel, which is NAD+. NMN can provide fuel, but now your body will produce NAD+ by itself, so why do you need to take NMN to improve your NAD+ level? This is the key part. As you get older, your NAD+ level begins to decline, which means there is not enough fuel to start your Sirtuins. This is why you need to increase the level of NAD+ when you are older, so you can supplement NAD+ by taking ACMETEA W+NMN. If you are over 30 years old, it is recommended that you take 1g ACMETEA W+NMN every morning to enter the cell, and it will enter you.
Intransitive Verb Living Management System: The molecular number of NAD+ is converted by the unit dose of ACMETEA W+NMN (per 100g), and the concentration of NMN in blood gradually rises within10min. Within 30min, NMN enters multiple tissues with blood circulation and synthesizes NAD+ in tissues, thus improving the level of NAD+.
In recent 3-4 years, Science, the most prestigious academic magazine in the world, has published human and animal studies continuously, which has repeatedly proved that supplementing NMN(ACMETEA W+NMN) can effectively increase and restore the level of coenzyme I in the body, greatly delay aging, prevent various neurodegenerative diseases such as Alzheimer's disease, and fundamentally adjust and improve various symptoms of aging. Other studies also involve cancer, infertility, obesity, cerebral hemorrhage, heart failure, heart injury, vascular aging, diabetes and so on. It shows that NMN supplement has many medical levels and human health potential.
Eight, Anquan management system: production technology, ACMETEA W+NMN "cold pressed biological enzyme" production technology, the purity of extracted NMN is as high as 99%, and the content of each bottle is as high as 12000mg. ACMETEA W+NMN is also the highest content among NMN brands at present. The basic system of OULF EU safety standards strictly abides by the factory safety inspection, strictly examines the microbial heavy metals exceeding the standard, and scientifically extends the production technology.
Raw material management system: Many NMN manufacturers, raw materials are certified in a single country, but the real safety level needs dual-country certification. At present, ACMETEA W+NMN products belong to French and American certification standards. In terms of raw materials, it has reached strict and safe management standards.
X. Anquan management system: ACMETEA W+NMN conforms to the standards stipulated by the US FDA for the GMP of dietary supplements, which is a set of mandatory standards applicable to industries such as medicine and food, and requires enterprises to meet the hygiene quality requirements in terms of raw materials, personnel, facilities and equipment, production technology, packaging and transportation, quality control, etc. according to relevant national laws and regulations;
ACMETEA W+NMN complies with relevant regulations of European Food Safety Agency (EFSA), European food supplements and OULF EU laws. The purpose is to ensure that the nutrition and health information provided to consumers on food packaging is accurate and reliable, so as to avoid misunderstanding by consumers. The basic purpose of this regulation is to provide coordination of laws and regulations on nutrition and health claims of food and related functional foods among EU member States in terms of labeling, introduction and advertising, so that related foods can circulate freely among member States. Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)
Review the knowledge points. Is again Fairy Medicine Pseudo-science?
20 18 can be said to be the year when the anti-aging drug NMN first officially entered the public eye. The Daily Mail published an article entitled "China Scientists Invent the World's First Drug, Live 150 Years". This paper describes the magical anti-aging function of NMN, which is expected to make people live to 150 years old. In 2020, the price of taking NMN every day will be as low as a cup of coffee. This article is actually a double-edged sword, which not only makes NMN famous, but also makes the translated article spread wildly in China, and thousands of people talk about this awkward English word. This also makes it a target of public criticism. It was not long before experts and scholars denounced it as one of the "top ten rumors of 20 18". Hit the face so fast, like a tornado, who should we trust?
In fact, before writing NMN, Ms Tingting, a healthy woman, searched NMN on the most popular search engine in China. Except for relevant scientific literature, she was immediately shocked by the "NMN scam", "NMN is fake" and "NMN pseudoscience" in the search recommendation. If I hadn't read the complete international NMN industry standard document "Ten International Core Standards of NMN Quality Management", I'm afraid Tingting was quietly dissuaded by these titles from the beginning. With a natural distrust of health care products, people are always more interested in this so-called "beating face" and "dispelling rumors"? Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)
Teacher Health Tingting must explain that the description of "living to 150 years old" is a comprehensive assumption made by various anti-aging achievements, which is very imprecise in the existing research results and loses the scientific nature of the article in order to attract readers. However, the anti-aging effect of NMN mentioned in this paper is by no means a myth, but the same conclusion drawn by different countries, different experiments and different researchers after relevant experiments.
With the development of science and technology, human beings began to realize aging at the end of the 20th century. Since Professor David Sinlcair of Harvard Medical School revealed the "life-prolonging" function of NMN on 20 13, NMN has become a star in academic circles. Only 20 19 published more than a dozen related articles, and in February released three NMN studies: regulating inflammatory aging, reversing nerve cell aging, and saving female fertility. Among them, the research on saving the fertility of elderly women is led by Professor David Sinclair of Harvard University and Professor Lindsay Wu of the University of New South Wales.
This substance improves the level of tissue activation. NMN originally exists in the cells of various organisms, and it is a substance similar to vitamins. However, NMN decreases with age, and the number of NMN can be artificially increased to inhibit aging and revive aging organs. Our bodies are gradually losing their functions, so the lost functions need to be repaired. The cell viability was successfully restored and the cell activity level was measured. Is nmn, a drug that delays human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)
The latest research found that the hypothalamus can issue powerful commands to organize the aging of the whole body, but this command will weaken with age. NMN stimulates the hypothalamus and may send this powerful tissue to the whole body again. We find that NMN determines the essence of human aging, and aging occurs in all parts of our body. 90% of the oxygen consumed by organisms is consumed by mitochondria, which convert ATP (nucleotide), which is called energy currency, into the energy needed by organisms for survival. The activation of mitochondria can maintain normal body function (improve the state of nerve conduction circuit and normalize visceral function), so it can be imagined that it is very important to provide vitality to mitochondria, and by activating it, the appearance of aging can be delayed.
Tingting's health teacher doesn't know if everyone is deceived. Besides improving learning ability, improving memory, protecting eyesight, reducing radiation damage and improving endurance, everyone should be most concerned about the potential of NMN in improving diabetes, cardiovascular and neurodegenerative diseases. These three age-related diseases can be said to be senile killers. Needless to say, Alzheimer's disease and Parkinson's disease should be the most terrible diseases of the elderly. Symptoms are weak, pathological mechanism is unknown, and drug treatment effect is poor. How many people are inexplicably infected with this disease. And NMN's performance in this respect can be said to be remarkable. The data results of these experimental animals are similar to the feedback of human body after taking NMN, which can confirm each other.
When people are young, the content of NAD+ is sufficient. Even if it is consumed in large quantities because of various unhealthy habits and behaviors, NAD+ will be replenished in a variety of ways because the body is in a vigorous growth and development period, so we will not feel tired. But at this time, our bodies have left hidden dangers, which began to appear after middle age. At this time, the content of NAD+ in our body will decrease sharply, and the body's ability to replenish itself will continue to weaken. If the damage rate of body cells exceeds the repair rate, our cells will continue to be damaged, aged and eventually die.
With more and more dead cells in various organs in the body, the ability of our body organs will be weakened and various symptoms will appear. The rigid demand and market capacity for a sense of security for the elderly are far greater than' basic necessities of life'. ACMETEA W+NMN is a substance that people find can significantly prolong life, and consumers of health care products ACMETEA W+NMN in the market have not reported obvious side effects. The FDA of the United States also gave ACMETEA W+NMN food additive raw material safety certification.
It should be noted that the NMN supplemented here is natural β-NMN. Many studies have confirmed that NMN itself is a non-toxic and harmless substance, but the difference of production technology will lead to the residue of some toxic substances in the production process. Nowadays, the health care products market is mixed, and it is difficult to distinguish between true and false, and the safety of products is often not guaranteed.
Do you like this summary? Teacher Tingting hopes to share anti-aging science with you in an easy-to-understand way! Re-emphasize that product selection should meet the ten core standards of NMN quality management! Is nmn, a drug for delaying human aging, pseudoscience? In-depth analysis of NMN mechanism and ten core standards)