Cui Yihao (Li Zhengzai) is a novice in ultimate fighting championship. One day, his brother suddenly disappeared, and he was targeted by the police because of a false and wrong case. The police arrested Yi Hao after confirming that he was suspected of murder.

Yihao received a strange phone call. The caller's name is Ace (Shin Ha-kyun), and he is the manager of an illegal gambling establishment. He built his "game" with high technology and closed-circuit television, which can capture any tiny movement of his chess pieces. What makes GAME special is that all the chess pieces he uses are real people. It was the kidnapping of Yi Hao's brother that forced Yi Hao to become their new minion.

Yihao is asked to get in touch with Xiujing (Bao Er) and obey her orders to save his brother. He needs to find his brother's position on the huge football field, and the fixed bomb tied to his ankle has been counting down. With the entry and approach of Ik-ho, Ace had to put all its eggs in one basket. Between two desperate people, the top contest is on the verge.