It's a bit like a small chip square, covered with many tiny needles, which can't be seen. Pressing this small square on the skin can let the medicine enter the epidermis, but people can hardly feel it.

According to the inventor, Dr. Xu Bobo, the percutaneous penetration of drugs can actually be achieved through a small hole, but at present they often use ordinary needles to penetrate under the dermis to deliver drugs, which will not only cause pain, but also cause infection. The diameter of ordinary needles is 300 microns, while the diameter of nano-microneedles is only 80 microns, which is thinner than hair and thinner than the thickness of epidermis. When injecting, just stick the small chip covered with microneedles on the skin, and the microneedles can penetrate the stratum corneum of the epidermis and play a role of drug barrier. Then, the patch of the drug is covered, and the drug will slowly penetrate into the epidermis, and the drug will be continuously administered quantitatively. The reporter "pressed" the skin with such a microneedle and felt nothing at all. The naked eye can't see any changes in the skin, and it does not hurt or bleed.

In fact, intradermal administration of nano-microneedles not only relieves patients' pain, but also has the advantages of reducing toxic and side effects, improving drug efficacy and accelerating drug absorption. For example, in Bai Xu, they are currently developing nano-microneedles to replace the long-term use of insulin pumps to administer drugs to patients. Because insulin is injected into the skin surface at a uniform speed, it can stabilize the blood sugar of patients. When blood sugar suddenly drops, the patch can be removed immediately, and the drug will stop entering the body, which is much safer than the traditional one-time quantitative injection. In addition, this technology can also be used in the field of beauty. Women who love beauty don't need to put needles on their faces for whitening, acne removing and wrinkle removing. And they can easily achieve the same effect through microneedles and patches.

Application field of nanometer microneedles

Mainly used in the field of beauty, some hospitals also provide this medical service, but it has not been included in the scope of public medical insurance for the time being. Nano-microneedle technology is a new drug delivery platform and a revolutionary invention in biomedical field. At present, there are 6 patents for this technology, and the production capacity has reached 500,000 pieces per year.