The absolute value of ret refers to the number of reticulocytes, which is a necessary stage in bone marrow hematopoiesis. Detecting the absolute value of ret is helpful to reflect the hematopoietic function of erythroid bone marrow and its compensation, which is of great significance to the diagnosis and treatment evaluation of anemia. However, due to the differences of different instruments and equipment, the normal reference range of RET absolute value is also different.
Generally speaking, the normal reference range of the absolute value of adult ret is (24 ~ 84 )× 10 9/L, while that of newborn is (100 ~ 300 )×109/L. If the absolute value of patients' RET is found to be lower than the normal range, it usually indicates that the erythroid bone marrow system cannot effectively compensate for proliferation or its proliferation ability.
On the contrary, if the absolute value of ret is found to be higher than the normal range, it usually indicates that patients may have hemolysis or active proliferation after stimulating erythropoiesis. Such as hemolytic anemia, acute blood loss or infection.
Influencing factors:
1. Type and degree of anemia: Different types of anemia will lead to changes in the absolute value of ret. Such as iron deficiency anemia, megaloblastic anemia and myelodysplastic syndrome. It will lead to the decrease of absolute value of ret, indicating that erythroid hyperplasia of bone marrow is decompensated or hypoplasia; However, various hemolytic anemia and hemorrhagic anemia will lead to the increase of absolute value of ret, indicating that erythroid hyperplasia of bone marrow is active.
2. Therapeutic effect of anemia: Effective treatment will promote the increase of absolute value of ret and reflect the recovery of bone marrow erythroid. For example, after effective treatment of iron deficiency anemia or megaloblastic anemia, ret began to increase in 2 ~ 3 days, reached the peak in 7 ~ 10 days (about 10%), and gradually decreased to the normal level after 2 weeks.
3. Other factors: some drugs, infection, inflammation, tumor and renal insufficiency will also affect the absolute value of ret. For example, erythropoietin (EPO) can stimulate bone marrow to release more ret；; Interleukin -6(IL-6) can inhibit the secretion and function of EPO during infection or inflammation, thus reducing the absolute value of ret.