2 English reference Xiangsha Liu Jun Pill [Chinese Medicine Terminology Committee. Terminology of Traditional Chinese Medicine (2004)]
Xiangsha Liu Jun Pill [Chinese Medicine Terminology Committee]. Terminology of Traditional Chinese Medicine (2004)]
3. Information on retail guidance price of national essential drugs and Xiangsha Liu Jun Pills.
Essential drug serial number
DirectoryNo. Drug name, dosage form and specification Retail unit refers to
Price Category Remarks 399 34 60g bottle of Xiangsha Liu Jun Pills 5.6 Chinese patent medicine part * 400 34 Xiangsha Liu Jun Pills 6g bag 0.66 Chinese patent medicine part 40 1 34 Xiangsha Liu Jun Pills 9g bag 0.97 Chinese patent medicine part 402 34 Xiangsha Liu Jun Pills 18g bag 1 .8 Chinese patent medicine part 403 34 Xiangsha Liu Jun Pill 30g bottle 2.9 Chinese patent medicine part 404 34 Xiangsha Liu Jun Pill 36g bottle 3.5 Chinese patent medicine part 406 34 Xiangsha Liu Jun Pill 54g bottle 5. 1 Chinese patent medicine part 407 34 Xiangsha Liu Jun Pill Concentrated Pill 200 pill bottle 7.7 Chinese patent medicine part *△ 408 34 Xiangsha Liu Jun Pill Concentrated Pill 192.
1. The dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms with "△" in the remarks column in the table, and other specifications of the same dosage form are tentative prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the drug price comparison rules.
4. The "honey pills" marked in the column of dosage form in the form include small honey pills and big honey pills.
4. Summarize Xiangsha Liu Jun Pill as a prescription and publish Redefining Popular Treatise on Febrile Diseases.
The main components of Xiangsha Liu Jun Pill are Radix Aucklandiae, Fructus Amomi, Ginseng Radix, Atractylodis Rhizoma (parched), Poria, Radix Glycyrrhizae Preparata, Pericarpium Citri Tangerinae, Rhizoma Pinelliae (processed), Rhizoma Zingiberis Recens and Fructus Jujubae [1]. Has the effects of invigorating qi, invigorating spleen and regulating stomach. For spleen deficiency and qi stagnation, dyspepsia, belching, anorexia, abdominal distension and loose stool.
The drug standards of People's Republic of China (PRC) and the Ministry of Health of the People's Republic of China contain the ministerial standards of Xiangsha Liu Jun Pills.
People's Republic of China (PRC) Pharmacopoeia (version 20 10) records the pharmacopoeia standard of Xiangsha Liu Jun Pills.
5 Efficacy and indications of Chinese patent medicine Xiangsha Liu Jun Pill Xiangsha Liu Jun Pill has the efficacy of invigorating qi and spleen, promoting qi circulation and regulating stomach, and is used to treat spleen and stomach weakness and qi stagnation pain [2].
Xiangsha Liu Jun Pill has the effects of invigorating qi, invigorating spleen and regulating stomach. For spleen deficiency and qi stagnation, dyspepsia, belching, anorexia, abdominal distension and loose stool. (People's Republic of China (PRC) Pharmacopoeia (20 10 Edition))
6. Revised Popular Treatise on Febrile Diseases named Xiangsha Liu Jun Pill 6. 1.
6.2 Radix Codonopsis, Poria, Rhizoma Cyperi preparata, Jiang Banxia 1, Guangpi 1, Radix Glycyrrhizae Preparata 1, and Fructus Amomi 1.
6.3 Xiangsha Liu Jun Pill has indications in the revised Treatise on Febrile Diseases, and is suitable for qi deficiency and stagnation, dyspepsia, nausea, fullness, stomachache, abdominal sound and diarrhea.
6.4 The usage and dosage of Xiangsha Liu Jun Pill is 23 yuan per dose.
6.5 Preparation method: water flooding into pills.
7 Xiangsha Liu Jun Pill 7. 1 Pharmacopoeia standard named Xiangsha Liu Jun Pill.
Xiangsha Liu Jun Pills
7.2 Prescription of Radix Aucklandiae 70g, Fructus Amomi 80g, Radix Codonopsis 100g, fried atractylodes 200g, Poria 200g, Radix Glycyrrhizae Preparata 70g, Pericarpium Citri Tangerinae 80g, and Jiang Banxia 100g.
7.3 Prepare the above eight medicines, pulverize them into fine powder, sieve them and mix them evenly. In addition, 10g ginger and 20g jujube were decocted in water for several times and filtered. Take the above powder, pan-pill with decoction, and dry at low temperature.
7.4 Characteristics This product is a yellow-brown water pill; The breath is slightly fragrant, and the taste is slightly sweet and pungent.
7.5 Identification (1) Take this product and observe it under the microscope: the irregular branched mass is colorless and soluble in chloral hydrate test solution; The mycelium is colorless or light brown, with a diameter of 4 ~ 6 microns (Poria cocos). Endosperm thick-walled cells are yellowish brown or reddish brown, with polygonal surface and thick wall, and the cell cavity contains siliceous blocks (Amomum villosum). The needle-like crystals of calcium oxalate are in bundles, with a length of 32 ~144μ m, existing in mucous cell towels or dispersed in Jiang Banxia. The parenchyma cells around the fiber bundle contain calcium oxalate crystals, forming crystalline fibers (roasted licorice).
(2) Take 5g of this product, grind it, add 30ml of ether, heat it in water bath and reflux it for 30min, filter it, evaporate the filtrate, and add 0.5ml of ethyl acetate to the residue to dissolve it as the test solution. Another 0.5g of Radix Aucklandiae was taken as the reference medicinal material, and 15ml of ether was added to prepare the reference medicinal material solution in the same way. According to the thin-layer chromatography test (Appendix ⅵ b of Pharmacopoeia I, 20 10), take 2μl of the test solution and the control medicinal solution 1μl, respectively, and spot them on the same silica gel G thin-layer plate with cyclohexane-acetone (10: 3) as the developing agent, unfold, take out, dry and spray 5% vanilla. In the chromatogram of the test sample, there are two identical purple-red to purple-blue spots in the position corresponding to the chromatogram of the control medicinal material.
(3) Take this product 12g, crush it, add ethanol 15ml, perform ultrasonic treatment for 30min, filter, and take the filtrate as the test solution. Take another hesperidin reference substance and add methanol to make a saturated solution as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), absorb 2μl of the above two solutions, respectively spot them on the same polyamide film, use chloroform-acetone-methanol (5: 1: 1) as the developing agent, unfold, take out, dry and spray with 65438. In the chromatogram of the test sample, fluorescent spots with the same color appear in the position corresponding to the chromatogram of the control sample.
(4) Take 5g of this product, grind it, add 20ml of ethyl acetate, perform ultrasonic treatment for 65438±05min, filter, evaporate the filtrate, and dissolve the residue with 2ml of chloroform as the test solution. In addition, 0.5g of Atractylodes macrocephala control medicinal material was taken, and 65438±00ml of ethyl acetate was added to prepare the control medicinal material solution by the same method. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), the above two solutions 10μl were absorbed, respectively, on the same silica gel GF254nm thin-layer plate, and cyclohexane-toluene-ethyl acetate (14: 3: 3) was used as the developing agent, then unfolded, taken out and dried. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(5) Take 5g of this product, crush it, add 30ml of methanol, heat and reflux for 30min, let it cool, filter, evaporate the filtrate, dissolve the residue with 5ml of water, and pass the water through D 10 1 macroporous adsorption resin column (inner diameter 1.5cm, column height1) in turn. Continue to elute with 50 ml of 30% ethanol and 50% ethanol respectively, collect 50% ethanol eluate, evaporate to dryness, and add 1 ml methanol to dissolve the residue as test solution. In addition, 0.3g of Glycyrrhiza uralensis Fisch was added with 65438±00ml of methanol, heated and refluxed for 30 minutes, cooled and filtered, and the filtrate was used as the control medicinal material solution. Then take liquiritin reference substance and add methanol to make a solution containing 65438±0mg per 65438±0ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), 2μl of each of the above three solutions was absorbed and spotted on the same silica gel G thin-layer plate, and ethyl acetate-formic acid-glacial acetic acid-water (15:1:2) was used as the developing agent. In the chromatogram of the test sample, in the sunlight, spots with the same color appear at the positions corresponding to the chromatograms of the reference medicinal materials and the reference substance; Under ultraviolet irradiation, fluorescent spots of the same color will appear.
(6) Take 10% ethanol eluent under [Identification ](5) for later use, evaporate it to dryness, and add 10% ethanol 1ml to the residue to dissolve it as a test solution. In addition, 0.5g of Codonopsis pilosula reference medicinal material was added with methanol 15ml, heated and refluxed for 30min, cooled, filtered, the filtrate was evaporated to dryness, and the residue was dissolved with 65438+5ml of methanol as reference medicinal material solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), absorb 5μl of the above two solutions, respectively spot them on the same silica gel G thin-layer plate, use toluene-ethyl acetate-formic acid (6: 4: 1) as developing agent, unfold, take out, dry and spray with1. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
7.6 The inspection shall comply with the relevant provisions under Pills (Appendix 1A of Pharmacopoeia 20 10).
7.7 The content was determined by high performance liquid chromatography (Appendix ⅵ D of China Pharmacopoeia I, 20 10).
7.7. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Acetonitrile -0.2% phosphoric acid solution (2 1: 79) was used as the mobile phase. The detection wavelength is 284 nm. The theoretical plate number should be not less than 3000 calculated by hesperidin peak.
7.7.2 Preparation of control solution Take an appropriate amount of hesperidin control substance, weigh it accurately, and add methanol to make a solution containing 40μg per 1ml.
7.7.3 Preparation of test solution Take 65438 00 g of this product, grind it to about 0.2g, weigh it accurately, put it in a conical flask with a stopper, add 25ml of methanol accurately, plug it, weigh it, soak it in cold water for 2 hours, ultrasonic (power 300W, frequency 50k Hz)65438±0h h, let it cool, and weigh it again.
7.7.4 Determination Method Accurately absorb 65,438 00μ l of control solution and test solution respectively, inject them into liquid chromatograph, and determine to obtain the product.
Every 1g of this product contains dried tangerine peel, calculated by hesperidin (C28H34O 15), which shall not be less than 4.0mg.
7.8 Indications: invigorating qi and spleen, and harmonizing stomach. Can be used for treating loose stool due to spleen deficiency and qi stagnation, dyspepsia, anorexia and abdominal distension.
7.9 Oral administration and dosage. 6 ~ 9g once, 2 ~ 3 times a day.
7. 10 storage seal.
7. 1 1 Edition People's Republic of China (PRC) Pharmacopoeia 20 10/Edition.
8. Standard Xiangsha Liu Jun Pill of Chinese Medicine Department 8. 1 Concentrated Pill
8.2 Pinyin name Xiangsha? Liu Jun? pale
8.3 standard number WS3B 138593
8.4 Prescription Radix Aucklandiae 70g Fructus Amomi 80g Radix Codonopsis? 100g？ Atractylodes macrocephala (fried) Poria cocos 200g? 200g licorice (honey baked)? 0g？ Dried tangerine peel 80g Pinellia ternata (processed) 100g ginger 10g? Jujube 20g
8.5 Make the above ten flavors, taking Radix Aucklandiae, Fructus Amomi and Radix Codonopsis? 50g is crushed into fine powder; Pinellia ternata was soaked in 45% ethanol as solvent, dried tangerine peel, ginger and Atractylodes macrocephala as solvent respectively for 24 hours according to the percolation method under fluid extract and extract (Appendix 17), then percolated, collected and combined percolates, recovered ethanol, and concentrated to the relative density of 1.30 ~ 65438+. Decoct the remaining Radix Angelicae Sinensis and Poria. Decoct with water for two times, the first time is 3 hours, and the second time is 2 hours. Combine decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 65,438+0.30 ~ 65,438+0.35 (20℃), mix the above powders with the thick paste, make pills, dry and polish.
8.6 Characteristics This product is a brown concentrated pill; The smell is slightly fragrant and pungent
8.7 Identification of this product, observed under the microscope: wood fiber is long, spindle-shaped, with a diameter of 16 ~ 24μ m, slightly thick wall and cross-shaped or herringbone holes. Endosperm stone cells are brown or reddish brown, with polygonal surface and thick wall, and the cell cavity contains siliceous blocks. The diameter of the connecting mammary duct is 12 ~ 14 micron, which contains fine particles.
8.8 The inspection shall conform to the customs regulations under pills (Appendix 8).
8.9 Indications: invigorating qi, invigorating stomach and regulating stomach. For spleen deficiency and qi stagnation, dyspepsia, belching, anorexia, abdominal distension and loose stool.
8. 10 Usage and dosage: Take orally 12 pills, three times a day.
8. 1 1 specifications Every 8 pills is equivalent to 3g of the original crude drug.
8. 12 storage seal.
9 Description of Xiangsha Liu Jun Pills 9. 1 Drug Name Xiangsha Liu Jun Pills
9.2 Medicine Chinese Pinyin Xiangsha Liu Jun Pill
9.3 Every 8 pills in the dosage form is equivalent to 3g of the original crude drug.
9.4 Characters Xiangsha Liu Jun Pills are yellow-brown water pills; The breath is slightly fragrant, and the taste is slightly sweet and pungent.
9.5 The main components of Xiangsha Liu Jun Pill are Radix Aucklandiae, Fructus Amomi, Pericarpium Citri Tangerinae, Radix Codonopsis, Rhizoma Pinelliae, Atractylodis Rhizoma, Poria, Radix Glycyrrhizae, etc.
9.6 The main functions of Xiangsha Liu Jun Pill are invigorating qi, invigorating spleen and regulating stomach. Can be used for treating loose stool due to spleen deficiency and qi stagnation, dyspepsia, anorexia and abdominal distension.
9.7 Usage and dosage of Xiangsha Liu Jun Pill for oral administration. 6 ~ 9g once, 2 ~ 3 times a day.
9.8 Precautions 1. Diet should be light, avoid alcohol and spicy, cold and greasy food.
2. People suffering from serious chronic diseases such as hypertension, heart disease, liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
3. Children, pregnant women, lactating women and the elderly and infirm should take it under the guidance of a doctor.
If the symptoms are not relieved after taking the medicine for 3 days, you should go to the hospital.
5. Xiangsha Liu Jun Pill is forbidden for those who are allergic, and should be used with caution for those who are allergic.
6. When the medicinal properties of Xiangsha Liu Jun Pill change, it is prohibited.
7. Children must use it under the supervision of adults.
8. Please keep Xiangsha Liu Jun Pills out of the reach of children.
9. If you are using other drugs, please consult a doctor or pharmacist before using Xiangsha Liu Jun Pills.
9.9 Drug Interaction If used together with other drugs, drug interaction may occur. Please consult a doctor or pharmacist for details.
9. 10 Remarks