For beauty seekers, the term hyaluronic acid should be familiar. Hyaluronic acid has been promoted as the basic ingredient of hydrating in countless beauty and skin care advertisements. In fact, hyaluronic acid, also known as hyaluronic acid, was first used in the field of consumer medicine and later used by beauty brands. It is not difficult to find out through the four issues of the list that hyaluronic acid has occupied the first place in the light medical beauty industry.

How did hyaluronic acid achieve the production ratio of 1: 1000?

Hyaluronic acid is a kind of linear polysaccharide existing in human body, which is widely used in medicine, cosmetics, food and other fields because of its good water absorption and viscoelasticity.

1934, Karl Meyer, an American university professor, first discovered that there is a substance that can capture moisture, moisturize and lubricate the eyeball, synovial fluid and skin of human and other animals. He named this substance "hyaluronic acid", which was later commonly known as "hyaluronic acid".

Hyaluronic acid can lock 1000 water molecules, small molecules can penetrate into the basal layer of skin to replenish skin moisture, and large molecules stay in the epidermis to prevent water loss.

Most importantly, hyaluronic acid is a self-contained substance of the human body, which has good biocompatibility and does not need to worry about rejection. These characteristics make hyaluronic acid undoubtedly an excellent moisturizing ingredient.

1985, Shiseido took the lead in preparing hyaluronic acid by microbial fermentation. 1985, Zhang Tianmin developed the first hyaluronic acid injection for ophthalmic surgery in China, which laid the foundation for HA research and clinical application in China, and successfully completed the research on hyaluronic acid production by fermentation in 1992.

Hyaluronic acid, which could only be extracted from bull's eyes and cockscomb flowers, was obtained through fermentation, which reduced the production cost of hyaluronic acid at once and ushered in an era when the public could enjoy the hyaluronic acid dividend. 20 1 1 Guo Huaxi, the chief scientist of biology, developed the world's first microbial enzyme digestion technology to produce full molecular weight HA on a large scale.

Hyaluronic acid has two main uses in medical beauty. First of all, hyaluronic acid is the main component of water-light needle, and its main function is to moisturize and replenish water. Two days ago, Lin Yun, a star girl, made a video of herself playing a water needle in Little Red Book. In fact, she injected hyaluronic acid directly into the dermis to directly replenish water. As can be seen from the comments, consumers now have a high degree of acceptance of water needles.

But hyaluronic acid is far more than a basic function of "hydrating and moisturizing". Crosslinking technology combines the molecules of hyaluronic acid into jelly-like plastic gel, which not only strengthens the supporting force of hyaluronic acid, but also slows down the absorption time, making hyaluronic acid a good filling material. Hyaluronic acid has a natural lysozyme "hyaluronidase". Compared with silica gel and swelling filling, injection of hyaluronic acid has almost no plastic risk, so it is widely used in medical cosmetic filling. Hyaluronic acid can not only pad the bridge of the nose and chin, but also improve static lines, which is deeply loved by beauty seekers.

According to statistics, in 20 18, 20 million people in China received medical cosmetic treatment, among which hyaluronic acid filling became the most popular medical cosmetic project in China. Hyaluronic acid is listed as one of the four great inventions of medical beauty in 20021New Oxygen Medical Beauty Industry White Paper.

From Huaxi Bio to Aimeike, leading enterprises lead hyaluronic acid to sit on its head.

In 20 19, the global hyaluronic acid raw material market sales reached 580 tons, with a compound growth rate of 20% from 2065438+05 to 2065438+09. According to Frost &; According to Sullivan's data, in 20 14, the market size of hyaluronic acid raw materials in China was 173 billion yuan, and it increased to 3.43 billion yuan in 20 19, with a compound annual growth rate of 14.7%. ISAPA data shows that in 20 19 years, hyaluronic acid injection accounted for 40% of plastic injection projects worldwide.

China is the largest producer of hyaluronic acid raw materials in the world, which almost monopolizes the global production of hyaluronic acid raw materials. According to Frost &; According to Sullivan's data, in 2020, the top five global hyaluronic acid raw material sales will all come from China. The total market share (CR5) is as high as 75%.

The preparation technology of hyaluronic acid in China is developed by Shandong Institute of Biomedicine, so the supply capacity of hyaluronic acid is concentrated in Shandong. Among them, Huaxi Bio is the largest hyaluronic acid production and sales enterprise in the world. After the acquisition of Chen Dong Bio, the output accounted for 43%.

The fermentation yield of biological hyaluronic acid in West China is as high as 12- 14g/L, and the production scale and output of hyaluronic acid are at the leading level in the world. In 2020, the production capacity of hyaluronic acid will be 320 tons/year.

Relying on the advanced hyaluronic acid cross-linking technology platform, Huaxi Bio has become a leading supplier of hyaluronic acid medical terminal products and functional skin care products in China, forming a brand matrix with brands such as "Runbaiyan" and "Kwadi" as the core; And continue to apply bioactive substances to medical terminal products, functional skin care products and foods, and strive to build an ecological circle of bioactive substances.

Huaxi Bio's brand "Runbaiyan" was listed in the mid-term American business list and ranked in the top three for three times, which shows its position in the hearts of consumers.

When it comes to the brand of hyaluronic acid, we have to mention the "neck-removing artifact"-"body" that won the first place in the hyaluronic acid category in the American business rankings four times.

Hi Body is the first commercial skin filler for repairing neck lines in China, and it is also the only commercial skin filler with this effect in the global market at present. Aimeike was approved for listing on 20 16. The appearance of scorpions has also brought anti-aging into the "face and neck era", and the injection site of hyaluronic acid has also expanded from the face to the neck.

In addition to Hime, there are many hyaluronic acid products of Aimeike, which can be divided into gel and solution according to the physical state. The solution includes Jimei and Yimei, and the gel is Bonida, Avery, Aimeifei and Yimei plus one. Among them, Avery is also on the American business list every time.

The "import myth" has not been broken, and domestic hyaluronic acid needs to strengthen the terminal brand building.

Although domestic hyaluronic acid occupies the market in raw materials, it has no obvious advantage in end products. Compared with the United States, Japan, South Korea and other countries, China's medical beauty industry started late, and the brand awareness of domestic medical beauty hyaluronic acid terminal products is not as good as that of imported products. The domestic hyaluronic acid terminal products market is still dominated by imported brands such as the United States, South Korea and Sweden, and 20 19 foreign brands account for about 68% of the market.

By September, 2020, there were 18 HA injection certificates in China, 8 were imported, 10 was made in China, and 27 brands of hyaluronic acid for injection were approved by NMPA. Among them, Joyaden is a high-end product, Yiwan and restylane are high-end, and other brands are positioned at the low end.

Domestic brands focus on the low-end route, and the unit price of products is low, mostly at 300-8000 yuan, and the competition is fierce. Foreign brands are mainly high-end products, and American brand "Joyaden" is mainly high-end market with a unit price of 8,000-20,000 yuan. Among the domestic brands, only the "Bonida" of Aimeike has entered the high-end product line of more than 10,000 yuan.

In the eyes of consumers, "domestic" has always been associated with "low price", while in the high-end market, American Joyaden, French Filoga and other brands occupy the minds of consumers. In the terminal market, domestic brands still need to strengthen brand building, support by science and technology, enhance brand premium ability and gain a place in the high-end market.

In the fourth American business list in March, in addition to hyaluronic acid, the list of institutions and doctors is also full of highlights. During the closure of Shenzhen due to the epidemic, Shenzhen Pengcheng Medical Beauty ranked first on the list, which seems to confirm the "lipstick effect"-when the economic crisis comes, the sales of lipstick cosmetics will increase, and beauty can alleviate social psychological anxiety.

In addition, the slap in the face of saving the ratings of the Oscar ceremony also put hair transplant institutions and projects on the list of American businessmen that week. As the weather gets warmer, slimming projects are gradually put on the agenda by beauty seekers.

References:

Special Report on Medical and Beauty Industry (III) —— The Red Book of Hyaluronic Acid Industry Analysis —— China Merchants Securities

Love Beauty: Leading the Trend of Medical Beauty, BOC International

Diversification and globalization, Ran Ran's rising medical beauty giant, Guo Sheng Securities