What material is good for removing wrinkles around the eyes by injection?
You can choose FOB.
The principle of TOOFOB:
Natural therapy, by simulating the guidance of skin scab, starts the body's self-repair function and naturally repairs metabolic atrophic cells and aging cells.
Through a large number of clinical medical studies, the team of experts from TOOFOB, France, found that when human skin tissue is damaged, the surface of the damaged part will scab, which is the beginning of the cell tissue repair process and represents the continuous natural repair activities of the covered part of the scab until the scab falls off.
TOOFOB is a biological skin made by the principle of human bionics, which can repair fine lines in 24 hours and old lines in 7 days. TOOFOB contains essential growth factors and repair factors. After using TOOFOB, the human body will automatically recognize that TOOFOB is a wound scab and quickly start the self-repair procedure. Orderly grab atrophic cells, damaged cells, aging cells and mutant cells for targeted repair and update. The essential growth factors and repair factors contained in its components provide nutritional support for the repair and generation of new cells. Clinical data show that the main application field of TOOFOB is the improvement of wrinkles.
Detailed explanation of components and repair factors of TOOFOB wrinkle repair patch;
1, fibroblast/skin growth factor (AFGF)
It can drive the growth of skin cells, accelerate tissue repair and promote cell healing. Dipeptide: It can promote cell healing, resist oxidation and has excellent anti-aging effect. AFGF is a multifunctional and powerful cytokine, which plays an important role in promoting the metabolism of fibroblasts and the formation of collagen.
AFGF can promote the growth and reproduction of skin tissue, regulate the division, reproduction, growth and differentiation of skin epithelium, endothelium and stromal cells by binding to cell surface specific receptors, promote cell metabolism and enhance oxidation; It can promote the rapid growth and reproduction of cells related to skin injury and regulate the synthesis, secretion and decomposition of intercellular matrix; Can promote the regeneration of stratum corneum cells, accelerate the repair of stratum corneum and matrix layer of skin, and promote the growth of human skin cells; It can enhance the protein synthesis and cell metabolism of skin cells, delay the aging of skin cells, promote the repair and growth of epidermal cells, and make skin smooth and rich.
FGFs is a protein family composed of 23 members (FG-FI-FGF230 1). It plays an important role in promoting the growth and development of the body and repairing tissue damage.
Promote the generation of new cells to replace the original cells. Mechanism: AFGF can actively bind to the specific receptors on the cell membrane near the wound, thus promoting cell division and reproduction and repairing the wound quickly and efficiently.
2. Stem cell growth factor (HGF)
Hepatocyte growth factor (HGF) is a protein factor existing in the plasma of animals with acute liver injury, which can stimulate DNA synthesis of hepatocytes. HGF not only acts on liver regeneration, but also plays an important role in regulating the growth and differentiation of many tissues and cells.
HGF can stimulate vascular endothelial growth factor (VEGF), significantly increase the mRNA expression and transcription activity of ets- 1, regulate and start cell regeneration, and promote cell division.
HGF has the function of similar diffusion factor (sF). Adding different concentrations of HGF to some epithelial and endothelial cell culture systems can promote cell diffusion and migration. Protect and repair the function of endothelial cells. When endothelial cells are injured, the structure or function of endothelial cells is damaged, and collagen and microfibers under dermis are exposed. HGF can prevent endothelial cell apoptosis. In vitro studies show that HOF can play an anti-apoptosis role by activating (ERK)/STAT3, silk/threonine protein kinase (Akt) and other signal transduction pathways.
HGF can repair endothelial cells by activating nitric oxide synthase system. Studies have shown that HGF can affect the expression of nitric oxide synthase (eNOS) in endothelial cells. In turn, it leads to phosphorylation and activation of eNOS and repairs endothelial cells. HGF promotes the DNA synthesis of endothelial cells, and the DNA synthesis stimulated by HGF is obviously stronger than that of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), which promotes angiogenesis and increases blood supply to tissues.
3. Nerve growth factor
Human nerve growth factor is a kind of protein, which can be obtained in many animals. Nerve growth factor can regulate the growth and development of peripheral and central neurons and maintain the survival of neurons. It plays an important role in regulating the development, differentiation, growth, regeneration and expression of functional characteristics of central and peripheral neurons.
NGF is mainly distributed in brain, ganglion, iris, heart, spleen, placenta, fibroblasts, smooth muscle, skeletal muscle, glial cells, Schwann cells and so on. It can repair nerve injury, stimulate sympathetic nerve and sensory neurons, and achieve the coordination effect on skin.
4. Keratinocyte growth factor
KGF is composed of mesenchymal cells, which specifically acts on epithelial cells. Participate in the development of tissues and organs; Participate in the repair of skin and epithelial injuries; It has the function of damage protection. Keratinocyte growth factor (KGF-2) is a basic protein growth factor secreted by human subcutaneous tissue cells, which can specifically stimulate physiological processes such as epithelial cell metabolism, including cell regeneration, differentiation and migration. KGF is transmitted by epidermal signal, which initiates the expression of genes involved in division and growth in epithelial cells, thus stimulating the metabolism of epithelial tissues.
EGF, bFGF, aFGF, TGF, VEGF and PDGF with biological effects are normal components of human cells. They play an important physiological role in the growth, differentiation, regeneration and migration of skin tissue cells, and stimulate the growth and division of new or aging epithelial cells.
5. Transforming growth factor (TGF)
TGF-β is named according to the phenotype that this cytokine can transform normal fibroblasts, that is, under the coexistence of epidermal growth factor (EGF), it can change the growth characteristics of fibroblasts and gain the ability to grow in agar. TGF-β3 is mainly produced by mesenchymal cells. TGF-β is used to treat wound healing and promote cartilage and bone repair. TGF-β stimulates mesenchymal cells, but inhibits epithelial or neuroectodermal cells. The regulation of cell phenotype promotes the growth of fibroblasts, osteoblasts and Schwann cells.
TGF-β 1 and TGF-β2 promote the production of IL-6 in human fibroblasts, and its mechanism may be through regulating the transcription of IL-6 gene. Inhibit the growth of epithelial cells, osteoclasts and endothelial cells and the formation of fat, myocardium and skeletal muscle. TGF-β can antagonize some biological functions of EGF. Promote the expression of extracellular matrix (ECM) such as collagen and fibronectin, and inhibit the degradation of ECM.
6. Vascular endothelial growth factor
Vascular endothelial growth factor gene consists of 8 exons and 7 introns. At present, the medical application of VEGF is developing in two directions: promoting angiogenesis around new cells, providing more nutrition, repairing vascular endothelium and accelerating tissue repair.
7. Fibroblast growth factor (BFGF)
Data show that bFGF has a wide range of biological functions, which can repair and consolidate fibroblasts and help skin blood circulation.
It plays a very important role in angiogenesis, promoting wound healing and tissue repair, promoting tissue regeneration and nerve tissue growth and development.
BFGF is a mitogenic cationic polypeptide with chemotaxis to single cells. As a mitogen, bFGF mainly acts on skeletal muscle cells, fibroblasts and bone cells from mesoderm and neuroectoderm. BFGF accelerates the transformation of cell phase, stimulates the enhancement of DNA synthesis, and promotes cell division and proliferation.
The biological effects of bFGF can be divided into two parts: in vivo and in vitro. It has a strong effect in vivo. Fibroblasts, osteocytes, chondrocytes, vascular endothelial cells, adrenal cortex and medulla cells, neurons and glial cells have strong activities to promote cell division and proliferation.
BFGF is an important mitogenic factor, and its main biological functions are: (1) as a vascular growth factor; (2) promoting wound healing and tissue repair; (3) promoting tissue regeneration; (4) Participate in nerve regeneration, etc.
In the study of peripheral nerve injury and repair, some data show that bFGF can promote the regeneration of peripheral nerve fibers, promote the differentiation of neural precursor cells and promote angiogenesis, thus affecting the development of central nervous system and peripheral nervous system.
1986, won the highest prize in human science-the Nobel Prize.
8. Insulin growth factor (IGF)
The full name of IGF- 1 is insulin-like growth factor 1. IGF- 1 is also called "growth promoting factor". It is of great significance in the growth and development of infants and the continuous anabolism of adults.
The known IGF- 1 is an active protein polypeptide, which is the product of autocrine and paracrine of more than a dozen cells such as liver cells, kidney cells and spleen cells in human body (that is to say, the human body itself contains IGF- 1).
Its specific functions are: lowering blood sugar, lowering blood fat, relaxing blood vessels, promoting bone anabolism,
Growth promotion: IGF- 1 is a very important mitotic promoter in human body.
Promote cell differentiation: IGF- 1 is very important to maintain the protein level related to cell differentiation, and it can promote cell differentiation and maturation when combined with some growth factors.
Wound repair: IGF- 1 is also involved in the process of wound healing. Experiments show that the concentration of IGF- 1 in injured nerve, muscle and skin cells increases.
It can effectively promote fat metabolism, synthesize collagen and elastic fiber, and smooth fine lines and wrinkles.
9. Platelet-derived growth factor (PDGF)
Platelet-derived factor (PDGF) can promote the activation of subcutaneous microvessels, and monocytes/macrophages in vivo are the main cells to synthesize PDGF.
In physiological state, PDGF is stored in platelets in the form of alpha particles, and both endothelial cells and activated hepatic stellate cells can secrete PDGF when cells are damaged. It works in autocrine and paracrine ways.
PDGF must bind to the corresponding receptors on the cell membrane in order to play its biological role. PDGF receptor is a transmembrane glycoprotein with tyrosine protein kinase activity. When the receptor binds to its ligand, cascade amplification of waterfall effect can promote the formation of dimer between two receptor molecules, activate the autophosphorylation of tyrosine residues in intracellular domain, or promote the phosphorylation of tyrosine residues in specific target protein, thus transmitting signals to the cell and regulating the life activities of the cell, including the division and proliferation of the target cell.
Experiments have proved that PDGF is an important mitogenic factor and has the ability to stimulate the division and proliferation of specific cell groups. The secreted PDGF stimulates the proliferation of mesenchymal astrocytes, transforms them into myofibroblasts, and promotes the migration and aggregation of astrocytes in damaged areas. However, myofibroblasts synthesize a large amount of extracellular matrix and deposit it in the cytoplasm of hepatocytes, which promotes the occurrence of liver fibrosis. PDGF can promote myofibroblasts to produce collagen, especially type I and type III collagen. The proliferation of mother cells makes the fused cells produce collagen, but it has no effect on their cell number. PDGF can also inhibit the action of collagenase by up-regulating tissue metalloproteinase inhibitor (TIMP- 1), thus reducing the degradation of extracellular matrix, repairing subcutaneous blood microcirculation system and providing sufficient nutrition for skin. Promote the synthesis of collagen.
10, epidermal growth factor
EGF is an active substance in human body, which can stimulate tyrosine phosphorylation of epidermal growth factor receptor, repair superficial cells of hyperplastic skin, and promote cell proliferation and differentiation, thus replacing aging and dead cells with new cells.
EGF can promote the growth and division of various cells in epidermal cells, make epidermal cells full, restore youthful state, promote the growth ability of collagen, and repair aging and broken collagen elastic fibers. EGF can promote the rapid renewal of human skin.
It is scientifically found that the natural molecular component factor RGF of callus is a cytokine component with automatic sensing function and two-way regulation, which can accelerate cell proliferation as needed in the initial stage of repairing injury, and automatically slow down the cell proliferation rate when the repair is close to perfection.
Experimental studies show that EGF can stimulate the proliferation of many kinds of cells, mainly epidermal cells and endothelial cells. Good results have been achieved in corneal injury, burn, surgical repair and healing. Professor Montalcini and Professor Cohen won the 1986 Nobel Prize in Physiology and Medicine for discovering epidermal growth factor and analyzing its structure and mechanism of action.
Factors affecting TOOFOB to repair wrinkles
Under normal circumstances, too FOB can repair fine lines in 24 hours, and 3-year-old lines in 7 days. The following factors will affect the repair of wrinkles:
1, with the increase of age, the cell cycle of fibroblasts in tissues is obviously prolonged, the normal repair reaction is slowed down, the synthesis of new blood vessels and collagen is reduced, the secretion function of sebaceous glands is reduced, the skin is dry, the adhesion between epidermis and dermis is reduced, the regeneration ability is weak, the metabolism of subcutaneous tissues is slow, and malnutrition is blocked during the repair process.
2, diabetes, arteriosclerosis, renal insufficiency:
Blood circulation is blocked, and hyperglycemia hinders inflammatory reaction, leukocyte dysfunction and collagen synthesis.
3. Drugs:
Reduce cellular components in bone marrow, reduce the number of inflammatory cells and platelets, and lack growth factors. Inhibit metabolism, reduce the diameter of collagen, and reduce the accumulation of collagen at the repair site.
4. Intense expression:
In the process of newborn cells, frequent facial expressions will squeeze newborn cells and damage newborn subcutaneous tissue, which is not conducive to the smooth completion of repair. Newborn cells are very fragile, and frequent extrusion will affect the differentiation of fibroblasts. Suggestion 1. Facial expression lines that move too deeply and frequently, combined with anti-wrinkle needles, relax facial muscles and relieve expressions through botulinum toxin. Recommendation 2: Reduce the habit of exaggerating expressions. Recommendation 3. After the repair is completed, get into the habit of using TOOFOB when sleeping, prevent it during the day and repair it at night.
Very good, can be used, I wish you always young and beautiful.