Scutellaria baicalensis Georgi and Gardenia jasminoides Ellis have the function of bitter cold and purging fire, and Gentiana scabra is mixed as the minister medicine in this prescription. Alisma orientalis, wooden barrels and plantain can clear away heat and promote diuresis, so that damp heat can be discharged from waterways. The liver governs the storage of blood, and the liver meridian is hot, which is easy to consume yin and blood. In addition, bitter cold is used to dry dampness and then consume its yin. In ancient times, Radix Rehmanniae and Radix Angelicae Sinensis were used as adjuvant drugs. The role of Bupleurum in the prescription is to introduce various drugs into the liver, gallbladder and meridians, and licorice has the function of reconciling various drugs.
Most of the drugs in this prescription are bitter and cold products, and each taste is easy to hurt the spleen and stomach, so it is not suitable for spleen and stomach deficiency or long-term use.
This prescription won't last long. Drugs containing Aristolochia have been banned, and Akebia manshuriensis is now on the market.
Mu Tong
Mu Tong
This product is the dried rattan stem of Akebia stem. )Decne。 Akebia trifoliata )Koidz。 Or Akebia trifoliata. )Koidz。 Var。 Australia (Diels) Rehd. Akebia is Akebia.
Processing is to remove impurities from the original medicine, wash it, thoroughly moisten it, slice it, dry it, and screen out the ash.
Description: This product is a round tablet with a diameter of 1 ~ 2 cm. The surface is grayish brown to grayish brown with prominent lenticels and lateral branch marks. The cuticle of the cut surface is yellow-brown, fibrous and thick, the wood is yellowish white or grayish white, and the pith is small or hollow. Light weight and solid quality. Slight gas and bitter taste.
Identification uses oleanolic acid reference substance and hederagenin reference substance, and adds methanol to make a solution containing 0.2mg per 65438±0ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of China Pharmacopoeia, 2005 edition), 65,438 00μ l of test solution and the above two kinds of reference solutions were respectively spotted on the same silica gel G thin-layer plate, and n-hexane-ethyl acetate-glacial acetic acid (6∶4∶0.25) was used as the developing agent, and then unfolded and taken out. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
According to the moisture determination method (China Pharmacopoeia, 2005, Appendix ⅸ h, First Method), the moisture content shall not exceed 10.0%.
The total ash content shall not exceed 6.5% (Appendix ⅸ K of China Pharmacopoeia 2005).
The content was determined by high performance liquid chromatography (China Pharmacopoeia 2005).
Chromatographic conditions and system applicability test with octadecylsilane bonded silica gel as filler; The mobile phase was methanol-water-glacial acetic acid-triethylamine (87∶ 13∶0.04∶0.02). The detection wavelength is 2 10nm. The theoretical number of oleanolic acid peaks should be no less than 2000.
Preparation of reference solution: Accurately weigh appropriate amounts of oleanolic acid reference substance and hederasaponin reference substance, and add methanol to make a mixed solution containing 65,438+0 mg per 65,438+0 ml.
Preparation of test solution Take about 2g of this product powder (pass through No.4 sieve), weigh it accurately, add 50ml of methanol, perform ultrasonic treatment (power 250W, frequency 50khz) for 30min, filter, wash the residue with methanol, combine the filtrate and lotion, recover the solvent to dryness, add 10ml of water to dissolve the residue, shake and extract with water-saturated n-butanol for three times, 20ml each time, and combine the extractive solutions. Add 20 ml of methanol and 2 ml of hydrochloric acid to the residue, heat and hydrolyze for 4 hours, add 65,438+/-00 ml of water to the hydrolysate, shake and extract with chloroform for 2 times, 20 ml each time, combine the extractive solutions, recover the solvent to dryness, dissolve the residue with methanol, transfer to a 65,438+-00 ml volumetric flask, add methanol to the scale, shake well, and filter to obtain the continuous filtrate.
Determination method: Accurately suck 20μl of control solution and test solution respectively, inject them into liquid chromatograph, and determine.
The total contents of oleanolic acid (C30H48O3) and hederagenin (C30H48O4) in this product shall not be less than 0. 10% in terms of dry products.
Sexual taste, bitter menstruation, slightly cold. Return to the heart, small intestine and bladder intestine.
Indications: clearing away heart fire, inducing diuresis and dredging menstruation, and promoting lactation. Used for chest distress, sore throat, red and astringent urine, stranguria, edema, general labor pains, amenorrhea and hypogalactia.
Usage and dosage 3 ~ 6g.
Store in a dry place.
The 2005 edition of processing specification published in Shanghai.