It plays an important role in blood coagulation and fibrinolysis. The detection of protein S activity belongs to physiological anticoagulant factor test. Many diseases, such as liver disease, kidney disease and cardiovascular disease, will affect the content of Ps in blood. Therefore, the determination of Ps in blood is of great significance for the prevention and diagnosis of the above diseases, observation of the disease condition and prognosis judgment.
If Ps activity decreases, it may indicate that the level of anticoagulant in plasma is abnormal, which may be thrombophilia. Ps deficiency may also occur during oral contraceptives, acute inflammation and oral anticoagulants.
Extended data:
PS, protein C, protein C inhibitor and thrombomodulin * * constitute an important anticoagulant system in the body-protein C anticoagulant system, which plays an important balance role in the process of coagulation and fibrinolysis.
It exists in plasma in two forms, free PS(FPS) and PS-bound complement (C4bp-PS). It is generally believed that only FPS has anticoagulant activity. Protein C and protein S should be detected when patients have thrombotic events or thrombosis, especially when patients are young and/or have no other obvious causes of thrombosis.
Baidu Encyclopedia-Protein S Activity