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Pharmacological and Toxicological Study on Konjac Capsule
Prevent and delay the absorption of glucomannan, which has strong water retention characteristics, make people feel full after eating, keep the intestines full, promote the physiological peristalsis of the intestines and speed up defecation. Glucomannan has a high viscosity and can form a protective film on the intestinal wall to prevent the intestinal tract from absorbing harmful substances. Glucomannan can effectively resist the absorption of lipolytic substances such as cholesterol and bile acids in the small intestine, promote the excretion of fat, reduce the entry of fat and cholesterol into the blood, and reduce the total amount of triglycerides and cholesterol in serum.

Reducing fat synthesis and promoting fat excretion can improve lipid metabolism and insulin sensitivity. Insulin is the main anti-lipolysis hormone in the body, and its level directly affects the synthesis and lipolysis ability of adipocytes. Insulin can inhibit the activity of triglycerides, reduce the hydrolysis of triglycerides and promote the re-esterification of newly hydrolyzed free fatty acids. Chitosan has a special function of adhering to fat. The amino chain of glucomannan in the composition has quaternary ammonium ions, which has a high anion exchange function. It can combine with triglycerides, fatty acids, bile acids, cholesterol and other organisms to form a complex, which is not easy to be hydrolyzed by gastric acid and digested by the digestive system, thus preventing the digestion and absorption of these substances and promoting their excretion.

The survey results of the European Union Health and Weight Loss Association show that as many as 99.2% of obese people are acidic. Acidic constitution directly leads to the acceleration of fat in body fluids to generate fat cells, thus alleviating the acidification level of body fluids and forming obesity. High-fat and high-sugar foods are mostly acidic foods, which will produce acidic decomposition products and fatty acids after digestion, making the body sour. Chitosan is a polycationic compound with positive charge, and its decomposition product in human body is glucosamine, which is weakly alkaline and can neutralize acidic substances in the body and maintain acid-base balance in the body.