The speed and slope of the treadmill are used to adjust the intensity of exercise, which is generally reflected by the heart rate during exercise. If the goal is to reduce fat, it is best to keep the heart rate in the range of 50%~75% when exercising, which is the best effect. So the specific slope and speed should be adjusted according to your heart rate during exercise.
For people who need to lose weight, it is best to exercise for 50 to 60 minutes at a time, not less than 5 times a week, and it is best to exercise every day.
The calf may indeed thicken at the beginning of running, but don't worry, this is a normal phenomenon caused by muscle congestion, and the body will return to its original state after adapting or stopping exercise. There is also the main reason why women's calves are thick is that subcutaneous fat is too thick, which is not caused by muscle growth. And the intensity of exercise like running won't grow muscles.
It is best to stretch 15 minutes after running. It is very helpful for shaping.