Adults take a relatively large dose of vitamin E(D-α- tocopherol 400 ~ 800 mg/day) for several years without any obvious damage. People who take 800~3200mg/d occasionally have muscle weakness, fatigue, vomiting and diarrhea. Vitamin E >；; The most obvious toxic effect of 1000mg/d is to antagonize the effect of vitamin K. Enhancing the effect of oral coumarin anticoagulants can lead to obvious bleeding.
Robert, an American medical expert, suggested that taking large doses of vitamin E for a long time would cause various diseases. Among them, thrombophlebitis or pulmonary embolism, or both occur at the same time, because large doses of vitamin E can cause platelet aggregation and formation; When blood pressure rises, it can be reduced or returned to normal after drug withdrawal.
Both men and women can have breast hypertrophy, headache, dizziness, dizziness, blurred vision, muscle weakness, chapped skin, cheilitis, angular stomatitis and urticaria; Symptoms of diabetes or angina pectoris are obviously aggravated; Hormone metabolism disorder, prothrombin reduction; Blood cholesterol and triglyceride levels increased; Platelets increase, vitality increases, and immune function decreases.
Extended data:
Taboos for taking:
When vitamin E is used together with the following five drugs, it must be carried out under the guidance of a doctor. Don't take it yourself.
Aspirin: Both vitamin E and aspirin can reduce blood viscosity, so when taking vitamin E and aspirin at the same time, the doctor should adjust the patient's dose according to the specific situation.
Vitamin K: Vitamin E has antagonistic effect on vitamin K, which can inhibit platelet aggregation and reduce blood coagulation. Therefore, please don't take vitamin E before operation or while taking anticoagulant drugs.
Digitalis: Vitamin E can enhance the cardiotonic effect of digitalis. Patients who use such drugs should use vitamin E with caution to avoid digitalis poisoning.
Neomycin: drugs that affect absorption, such as neomycin, will affect the absorption of vitamin E, so taking them at the same time may reduce the efficacy of both.
Estrogen: Long-term high-dose (more than 400mg per day) taking vitamin E, especially when combined with estrogen, can induce thrombophlebitis, so we should be vigilant.
In addition, if vitamin E is taken together with acetone benzyl hydroxycoumarin (a coagulant), it will increase the possibility of abnormal bleeding. Cholesterol-lowering drugs called bile acid chelating agents (such as coletipol and coleenamine) will reduce the absorption of vitamin E, which will interact with cyclosporine (a drug for treating cancer) and reduce its curative effect.
Compatibility contraindications of vitamin e:
Tocopherol is incompatible with peroxides and metal ions, especially iron, copper and silver ions. Tocopherol can be absorbed by plastics.
References:
Baidu encyclopedia-vitamin e