At the end of the 20th century, from the strategic height of "people are the foundation of medicine", the author first announced the research results of medical model in the new century, namely, the combination of biology, psychology and society, passive (treatment, health care and beauty done by doctors) and active (treatment, health care and beauty done by patients under the guidance of doctors). This is a little experience after more than 30 years of thinking, practice, exploration and efforts on the basis of reviewing the development history of human medical model. In recent years, it has been recognized and supported by many peers and experts, and has been spurred and encouraged. Since the medical model in the new century covers all factors related to human diseases, health and medical treatment, this paper comprehensively analyzes the comprehensive effects of various internal and external factors on health, beauty and longevity from the perspective of holistic medicine. A brand-new bio-psycho-social, passive and active medical model not only covers all the contents of bio-psycho-social medical model, but also makes up for the shortcomings of modern medical model. Its core is to fully affirm the positive and important role of bio-psychological-social medical model in human diseases, health, beauty and longevity, and at the same time highlight another principle, that is, we should attach great importance to people-oriented and the combination of passive and active in doctor-patient interaction. It is a reflection, supplement, sublimation and integration of modern medical model, and it is a more advanced and scientific medical model. It has an important influence and positive significance on human diseases, health, beauty and longevity. Therefore, the medical model in the new century has attracted more and more attention, welcome and support from people, acupuncture, massage, Chinese medicine, beauty, weight loss, health preservation and medical professionals. People call for the birth of the medical model era in the new century.