As early as Qin and Han Dynasties, it was recorded in Shennong Herbal Classic that 165 kinds of drugs could "improve intelligence and prolong life". Since then, Yamatonokusushi, a physician, has attached great importance to the research of anti-aging drugs. Modern evidence shows that many drugs have certain effects of enhancing immune function and delaying aging, such as Lycium barbarum, Polygonum multiflorum, Polygonatum sibiricum, Ginseng, Acanthopanax Senticosus, Walnut, Sea Cucumber and so on. Later generations recorded 109 prescriptions to prolong life in Renshou Lu, including Huoguilingji, Flat Peach Zhushoudan, Wujiapi Wine, Yangyuan Powder and so on. Starting from tonifying the kidney and strengthening the spleen, it does have a good clinical effect.